Patent EP0204334A2 successfully refreshed from Google Patents.
EP0204334A2
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EP
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Integral multilayer analytical element for analysis of ammonia-forming substrate
Assignee: Fujifilm Holdings Corp
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Filing: 1986-06-04
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Granted: —
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Expires: 2006-06-04
Abstract
Abstract An integral multilayer analytical element for the analysis of an ammonia-forming substrate comprising: (I) a light-transmissive, liquid-impermeable support; (II) an ammonia indicator layer containing a reagent capable of undergoing a detectable change by gaseous ammonia; (III) a liquid barrier layer which allows gaseous ammonia passing therethrough; (IV) an ammonia-forming substrate reaction layer containing a reagent capable of reacting with an ammonia-forming substrate to form gaseous ammonia; (V) an intrinsic ammonia trapping layer containing a reagent which acts on intrinsic ammonia to convert it into a form which can not reach said reaction layer; and (VI) a porous spreading layer, in a laminate form.
Inventors
- 👤 Nobuyoshi C/O Fuji Photo Film Co.Ltd. Sekikawa
- 👤 Harumi C/O Fuji Photo Film Co.Ltd. Katsuyama
- 👤 Asaji C/O Fuji Photo Film Co.Ltd. Kondo
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 08:54
CPC Classifications
G; G01; G01N; G01N31/00; G01N31/22; G01N31/223; C; C12; C12Q; C12Q1/00; C12Q1/26; C12Q1/32; C12Q1/58; G01N33/00; G01N33/48; G01N33/50; G01N33/84
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
123 words
An integral multilayer analytical element for the analysis of an ammonia-forming substrate comprising: (I) a light-transmissive, liquid-impermeable support; (II) an ammonia indicator layer containing a reagent capable of undergoing a detectable change by gaseous ammonia; (III) a liquid barrier layer which allows gaseous ammonia passing therethrough; (IV) an ammonia-forming substrate reaction layer containing a reagent capable of reacting with an ammonia-forming substrate to form gaseous ammonia; (V) an intrinsic ammonia trapping layer containing a reagent which acts on intrinsic ammonia to convert it into a form which can not reach said reaction layer; and (VI) a porous spreading layer, in a laminate form in this order with the proviso that said (I) is the lowermost member and said (VI) is the uppermost layer.
Claim 2
Dependent Claim
123 words
An integral multilayer analytical element for the analysis of an ammonia-forming substrate comprising: (I) a light-transmissive, liquid-impermeable support; (II) an ammonia indicator layer containing a reagent capable of undergoing a detectable change by gaseous ammonia; (III) a liquid barrier layer which allows gaseous ammonia passing therethrough; (IV) an ammonia-forming substrate reaction layer containing a reagent capable of reacting with an ammonia-forming substrate to form gaseous ammonia; (V) an intrinsic ammonia trapping layer containing a reagent which acts on intrinsic ammonia to convert it into a form which can not reach said reaction layer; and (VI) a porous spreading layer, in a laminate form in this order with the proviso that said (I) is the lowermost member and said (VI) is the uppermost layer.
Claim 3
Dependent Claim
40 words
The integral multilayer analytical element as claimed in claim 1, wherein said intrinsic ammonia-trapping layer contains NA D H and/or NADPH, a-ketoglutaric acid and glutamate dehydrogenase and the pH or the layer is in the range of 7.0 to 8.5.
Claim 4
Dependent Claim
52 words
The integral multilayer analytical element as claimed in claim 1, wherein said intrinsic ammonia-trapping layer contains NADH and/or NADPH in an amount of at least 80 mg./m 2 , a-ketoglutaric acid in an amount of at least 400 mg./m 2 and glutamate dehydrogenase in an amount of at least 2,000 units/m .
Claim 5
Dependent Claim
34 words
The integral multilayer analytical element as claimed in claim 1, wherein said intrinsic ammonia-trapping layer contains aspartase and fumaric acid and the pH or the layer is in the range of 7.0 to 8.5.
Claim 6
Dependent Claim
39 words
The integral multilayer analytical element as claimed in any one of claims 1 to 4, wherein said reaction layer contains enzyme capable of reacting with creatinine to form ammonia and said element is used in the analysis of creatinine.
References Cited (Backward Citations)
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