Patent EP0198257A2 successfully refreshed from Google Patents.
EP0198257A2
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Method and apparatus for selective irradiation of biological materials
Assignee: Individual
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Filing: 1986-03-19
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Granted: —
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Expires: 2006-03-19
Abstract
Abstract The invention relates to a method and an ap- p aratus for frequency selective irradiation of biological materials and particularly tissues, cells and/or cell components of living organisms, in particular of human and animals, by irradiating a component element of the target material at the corresponding Mossbauer absorption frequency. The component radiation absorption at the Mossbauer absorption frequency is thus enhanced many times over the absorption of the surrounding material having a different Mossbauer absorption frequency. The energy thusly absorbed by the target material component is converted to and remitted as Auger electrons, which provide intranuclear radiation resulting in lethal double strand breaks in the DNA molecules of the target tissue. The irradiation is administered in frequency and material selective modes of treatment, and may be combined with conventional chemotherapeutic agents to provide a further enhanced treatment modality. Moreover, the source frequency can be adjusted to enhance the killing effect. The method of apparatus according to the present invention are useful in combination with naturally occurring or administered pharmaceutical stable isotope absorbers, having significantly reduced side effects by comparison to conventional chemotherapy or radiation therapy. The method and apparatus according to the invention can be applied for selective radiation therapy providing selective tissue damage or necrosis, in particular for cancer therapy, and for differentiating between diseased and normal tissues.
Inventors
- 👤 Randell L. Mills
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-27 10:42
CPC Classifications
A; A61; A61K; A61K41/00; A61K41/0085; A61K51/00; A61K51/12; A61N; A61N5/00; A61N5/10; A61K2121/00; A61N2005/1092; A61N2005/1098
Claims Analysis
Total Claims: 52
Claim 1
Independent Claim
82 words
A method for the selective irratiation of biological materials, particularly of tissues, cells and/or cell components, with the exception of methods for the therapeutical and surgical treatment of the human or animal body and diagnostic methods practised on the human or animal body, characterized by determining the MoBbauer absorption frequency of a component of the material to be irradiated and irradiation of said material with y-radiation of the corresponding MöBbauer absorption frequency with internal conversion and emission of y-radiation and/or Auger electrons.
Claim 2
Independent Claim
82 words
A method for the selective irratiation of biological materials, particularly of tissues, cells and/or cell components, with the exception of methods for the therapeutical and surgical treatment of the human or animal body and diagnostic methods practised on the human or animal body, characterized by determining the MoBbauer absorption frequency of a component of the material to be irradiated and irradiation of said material with y-radiation of the corresponding MöBbauer absorption frequency with internal conversion and emission of y-radiation and/or Auger electrons.
Claim 3
Dependent Claim
22 words
The method of claim 1, characterized by tunning a -y-radiation source with selective y-radiation frequency to the M b Bbauer absorption frequency.
Claim 4
Dependent Claim
24 words
The method of claim 1 or 2, characterized by filtering the selective γ-radiation frequency of the γ-radiation source to provide a single frequency γ-radiation.
Claim 5
Dependent Claim
27 words
The method of claim 1 or 2, characterized by adjusting the frequency of the emitted γ-radiation according to the radiation absorption of the material to be irradiated.
Claim 6
Independent Claim
27 words
The method according to one of claims 1 to 4, further characterized in that the radiation emitted by the excited component of the irradiated material is detected.
Claim 7
Dependent Claim
30 words
The method of claim 5, further characterized in that the frequency of the emitted radiation is adjusted according to the detected radiation of the excited component of the irradiated material.
Claim 8
Dependent Claim
31 words
The method according to claim 6, characterized in that the fluorescence radiation emitted by the irradiated material is detected in a direction different from the axis direction of the incident radiation.
Claim 9
Independent Claim
27 words
The method according to one of claims 1 to 7, characterized in that the irradiated material is imaged according to the detected radiation of the excited component.
Claim 10
Independent Claim
51 words
The method according to one of claims 1 to 8, characterized in that an active ingredient, particularly a pharmaceutical or a pharmaceutical active ingredient, or a composition, particularly a pharmaceutical composition, is added to the material to be irradiated or administered to an organism, whereby the component to be excited selectively
Claim 11
Dependent Claim
21 words
absorbs exciting energy at the M6Bbauer frequency determined according to said active ingredient or composition and/or the material to be irradiated.
Claim 12
Dependent Claim
21 words
absorbs exciting energy at the M6Bbauer frequency determined according to said active ingredient or composition and/or the material to be irradiated.
Claim 13
Dependent Claim
25 words
The method according to claim 9, characterized in that active ingredients, pharmaceuticals or compositions are used which consist of an isotope or comprise an isotope.
Claim 14
Dependent Claim
22 words
The method according to claim 10, characterized in that said isotope is used as M6Bbauer absorber isotope or MoSbauer resonance isotope, respectively.
Claim 15
Independent Claim
55 words
The method according to one of claims 9 to 11, characterized in that a radiation source emitting y-radiation at a selective frequency and an absorber isotope or a resonance isotope, respectively, are used which absorbs γ-radiation in accordance to the respective MoBbauer frequency and is localized at specific sites in the material to be irradiated.
Claim 16
Independent Claim
39 words
The method according to one of claims 10 to 12, characterized in that active ingredients, pharmaceuticals and/or compositions comprising an isotope are used which is selected according to the affinity of said isotope for the material to be irradiated.
Claim 17
Independent Claim
68 words
The method according to one of claims 10 to 13, characterized in that the active ingredients, pharmaceuticals and/or compositions comprising an isotope are administered selectively to the material to be irradiated according to the blood flow of the material to be irradiated or a tissue to be irradiated, wherein the amount of said isotope applied corresponds to the blood concentration in the material or tissue to be irradiated.
Claim 18
Independent Claim
56 words
The method according to one of claims 10 to 14, characterized in that for providing an increased concentration of the radiation of the excited component active ingredients, pharmaceuticals and/or compositions comprising an isotope are used which is selected according to the differential isotope uptake of the material to be irradiated or a tissue to be irradiated.
Claim 19
Independent Claim
48 words
The method according to one of claims 10 to 15, characterized in that active ingredients, pharmaceuticals and/or compositions comprising an isotope are used which is selected according to the effective penetration depth of the corresponding MoBbauer frequency of said isotope at the material or tissue to be irradiated.
Claim 20
Independent Claim
41 words
The method according to one of claims 10 to 16, characterized in that active ingredients, pharmaceuticals and/or compositions are used wherein the isotope is bound to be a carrier substance having an affinity for the material or tissue to be irradiated.
Claim 21
Dependent Claim
31 words
The method according to claim 17, characterized in that active ingredients, pharmaceuticals and/or compositions are used wherein the carrier substance comprises or consists of a monoclonal antibody and/or a natural hormone.
Claim 22
Dependent Claim
32 words
The method according to claim 18, characterized in that active ingredients, pharmaceuticals and/or compositions are used wherein the carrier substance represents or comprises a monoclonal antibody and/or a hormone and/or a toxin.
Claim 23
Independent Claim
34 words
The method according to one of claims 10 to 19, characterized in that active ingredients, pharmaceuticals and/or compositions are used which represent or comprise at least one of the following nuclides as MoBbauer absorbers:
Claim 24
Independent Claim
35 words
The method according to one of claims 10 to 20, characterized in that a least one of the following nuclides or at least one of the following nuclide combinations, respectively, are used as y-radiation source:
Claim 25
Independent Claim
28 words
The method according to one of claims 9 to 21, characterized in that Mößbauer absorbers and Mößbauer sources are used which are selected from the following nuclide combinations:
Claim 26
Independent Claim
41 words
The method according to one of claims 1 to 22, characterized in that means for selective absorption of the γ-radiation addition of the radiation source are used which comprise or consist of a molecule, a protein molecule and/or a peptide molecule.
Claim 27
Dependent Claim
23 words
The method according to claim 23, characterized in that the means for selective absorption of radiation further includes naturally occuring and synthesized elements.
Claim 28
Independent Claim
29 words
The method according to one of claims 23 to 25, characterized in that the means for selective absorption of radiation comprise or consist of an isotope and/or a hormone.
Claim 29
Independent Claim
39 words
An apparatus for the selective irradiation of biological materials, particularly of tissues, cells and or cell components, in particularly on or of living organisms, specifically to externally and selectively provide demaging or necrosis of tissues or cells, characterized by
Claim 30
Independent Claim
39 words
An apparatus for the selective irradiation of biological materials, particularly of tissues, cells and or cell components, in particularly on or of living organisms, specifically to externally and selectively provide demaging or necrosis of tissues or cells, characterized by
Claim 31
Dependent Claim
26 words
-a radiation source (50) selectively emitting -y-radiation of a least one frequency and -a MoBbauer absorber located at or in the biological material to be irratiated.
Claim 32
Dependent Claim
26 words
-a radiation source (50) selectively emitting -y-radiation of a least one frequency and -a MoBbauer absorber located at or in the biological material to be irratiated.
Claim 33
Dependent Claim
74 words
The apparatus according to claim 26, characterized by -a radiation source (50) selectively emitting γ-radiation of a frequency corresponding to the MöBbauer frequency of the material to be irradiated, -means (60, 62, 64) for adjusting or tuning the frequency of the y-radiation emitted from the radiation source (50), -filter means (80) selectively transmitting the y-radiation emitted from the radiation source (50), and -means for selectively absorbing the radiation emitted from the radiation source (50).
Claim 34
Dependent Claim
37 words
The apparatus according to claim 26 or 27, characterized in that the means (60, 62, 64, 66) for adjusting or tuning the frequency of the y-radiation emitted from the radiation source (50) is a Doppler shift device.
Claim 35
Dependent Claim
20 words
The apparatus according to claim 27 or 28, characterized in that the filter means (18) comprise crystal diffraction means (84).
Claim 36
Independent Claim
23 words
The apparatus according to one of claims 26 to 29, further characterized by means (92) for detecting the radiation from the irradiated material.
Claim 37
Independent Claim
53 words
The apparatus according to one of claims 26 to 30, characterized in that the Mößbauer absorber being the component to be excited of the material to be irradiated is designed or selected such that it emits a radiation of sufficient intensity to cause demaging or necrosis of the irradiated material or irradiated tissues.
Claim 38
Independent Claim
40 words
The apparatus according to one of claims 26 to 31, characterized by means (92) for detecting the fluorescence radiation from the irradiated material caused by the irradiated filtered γ-radiation in a direction different from the irradiation direction of the y-radiation.
Claim 39
Independent Claim
24 words
The apparatus according to one of claims 26 to 32, characterized by means for imaging the irradiated material according to the radiation emitted therefrom.
Claim 40
Independent Claim
37 words
The apparatus according to one of claims 26 to 33, characterized in that the means for selective absorption of the -y-radiation emitted from the radiation source (50) (MöBbauer absorber) are atoms, molecules, protein molecules and/or peptide molecules.
Claim 41
Dependent Claim
26 words
The apparatus according to claim 34, characterized in that the means for selective absorption ( MöBbauer absorbers) include or consist of naturally occuring and/or synthesized elements.
Claim 42
Dependent Claim
36 words
The apparatus according to claim 34 or 35, characterized in that the means for selective absorption of the -y-radiation emitted from the radiation source (50) represent or comprise protein molecules and/or peptide molecules and/or other molecules.
Claim 43
Independent Claim
33 words
The apparatus according to one of claims 34 to 36, characterized in that the means for selective absorption of the radiation emitted from the radiation source (50) comprise an isotope and a hormone.
Claim 44
Independent Claim
37 words
The apparatus according to one of claims 34 to 38, characterized in that the means for selective absorption of the radiation emitted from the radiation source (50) are incorporated or located in the material to be irradiated.
Claim 45
Dependent Claim
40 words
The apparatus according to claim 38, characterized in that means for selective absorption of the radiation emitted from the radiation source (50) are administered or are present in the form of a pharmaceutical, a pharmaceutical ingredient or a pharmaceutical composition.
Claim 46
Independent Claim
22 words
The apparatus according to one of claims 26 to 29, characterized by at least one of the following nuclides as MoBbauer absorbers:
Claim 47
Independent Claim
35 words
The apparatus according to one of claims 26 to 40, characterized by at least one of the following nuclides or at least one of the following nuclide combinations, respectively, as y-radiation source - (Mößbauer source):
Claim 48
Independent Claim
25 words
The apparatus according to one of claims 26 to 41, characterized by a Mößbauer absorber and a Mößbauer source selected from the following nuclide combinations:
Claim 49
Dependent Claim
45 words
Use of the apparatus according to one of claims 26 to 42 for irradiating biological materials and particularly tissues, cells and/or cell components by selective irradiation with y-radiation with M6Bbauer absorption under such conditions that selective demaging or necrosis of the irradiated material is obtained.
Claim 50
Dependent Claim
22 words
Use of the apparatus according to one of claims 26 to 42 according to claim 43 for irradiating human and animal tissues.
Claim 51
Dependent Claim
20 words
Use of the apparatus according to one of claims 26 to 42 for the cancer treatment of human and animals.
Claim 52
Dependent Claim
23 words
Use of the apparatus according to one of claims 26 to 42 for differentiating between diseased or neoplastic and normal cells or tissues.
References Cited (Backward Citations)
US3257558A
Cited
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