Patent EP0193850A2 successfully refreshed from Google Patents.
EP0193850A2
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Partially methylated cyclodextrins and process for producing the same
Assignee: Sanraku Inc
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Filing: 1986-02-25
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Granted: —
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Expires: 2006-02-25
Abstract
Abstract This invention relates to partially methylated cyclodextrins with enhanced solubility in water wherein the average degree of methylation at hydroxyl groups of different positions in all the glucose units involved is at least 90% for 2-position, 25 to 35% for 3-position, and at least 95% for 6-position, when measured by 13 C-NMR analysis, and to a process for producing the same.
Inventors
- 👤 Yukio Tsuchiyama
- 👤 Michikatsu Sato
- 👤 Yoshiaki Yagi
- 👤 Tomoyuki Ishikura
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 14:40
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0012
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
45 words
Partially methylated cyclodextrins in which average degree of methylation at hydroxyl groups of different positions in all the glucose units involved is at least 90 % for 2-position, 25 to 35 % for 3-position, and at least 95% for 6-positions, when measured by 13C-NMR analysis.
Claim 2
Dependent Claim
45 words
Partially methylated cyclodextrins in which average degree of methylation at hydroxyl groups of different positions in all the glucose units involved is at least 90 % for 2-position, 25 to 35 % for 3-position, and at least 95% for 6-positions, when measured by 13C-NMR analysis.
Claim 3
Dependent Claim
13 words
Partially methylated cyclodextrins as defined in claim 1 wherein said cyclodextrin is P-cyclodextrin.
Claim 4
Dependent Claim
89 words
Partially methylated cyclodextrins as defined in claim 2 wherein the mixture has the following properties: A) Melting point 155-162°C B) Solubility About 133 grams of the mixture dissolve in 100 ml of water at 25°C. C) Average degree of methylation Average degree of methylation at hydroxyl groups of different positions in all the glucose units involved is about 95.1% for 2- position, about 30.6 % for 3-position and about 98.0% for 6-position, when measured by 13C-NMR analysis. D) Specific rotation [α] 25 D : 161.0° (c = 1, water)
Claim 5
Dependent Claim
93 words
Partially methylated cyclodextrins as defined in claim 3 wherein the mixture has the following properties: A) Melting point 153-157°C B) Solubility About 130 grams of the mixture dissolve in 100 ml of water at 25°C. C) Average degree of methylation Average degree of methylation at hydroxyl groups of different positions in all the glucose units involved is about 91.2 % for 2- position, about 29.9 % for 3-position and about 97.5% for 6-position, when measured by 13C-NMR analysis. D) Specific rotation [a] 2 5 D: 150 . 1 ° (c = 1, water)
Claim 6
Dependent Claim
82 words
A process for producing partially methylated cyclodextrins whose average degree of methylation at hydroxyl groups of different positions in all the glucose units involved is at least 90% for 2-position, 25 to 35% for 3-position, and at least 95% for 6-position when measured by 13C-NMR analysis, by reaction of a cyclodextrin with dimethyl sulfate, wherein more than about 30 equivalent proportions, based on said cyclodextrin, of diemthyl sulfate and more than about 30 equivalent proportions of an alkali metal hydroxide are used.
Claim 7
Dependent Claim
82 words
A process for producing partially methylated cyclodextrins whose average degree of methylation at hydroxyl groups of different positions in all the glucose units involved is at least 90% for 2-position, 25 to 35% for 3-position, and at least 95% for 6-position when measured by 13C-NMR analysis, by reaction of a cyclodextrin with dimethyl sulfate, wherein more than about 30 equivalent proportions, based on said cyclodextrin, of diemthyl sulfate and more than about 30 equivalent proportions of an alkali metal hydroxide are used.
References Cited (Backward Citations)
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