Patent EP0193372A2 successfully refreshed from Google Patents.
EP0193372A2
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EP
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Intranasally applicable powdery pharmaceutical composition
Assignee: Teijin Ltd
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Filing: 1986-02-24
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Granted: —
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Expires: 2006-02-24
Abstract
Abstract An intranasally applicable powdery pharmaceutical composition comprising a polypeptide having a physiological activity, a quaternary ammonium compound, and a lower alkyl ether of cellulose. This powdery pharmaceutical composition has an excellent preservability and chemical stability of the polypeptides and, when the powdery composition is administered to the nasal cavity in the form of a spray, the polypeptides are effectively absorbed through the nasal mucosa.
Inventors
- 👤 Kunio Sekine
- 👤 Daisuke Araki
- 👤 Yoshiki Suzuki
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 20:26
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0043; A61K47/00; A61K47/06; A61K47/16; A61K47/18; A61K47/186
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
25 words
1- An intranasally applicable powdery pharmaceutical composition comprising a polypeptide having a physiological activity, a quaternary ammonium compound, and a lower alkyl ether of cellulose.
Claim 2
Dependent Claim
25 words
1- An intranasally applicable powdery pharmaceutical composition comprising a polypeptide having a physiological activity, a quaternary ammonium compound, and a lower alkyl ether of cellulose.
Claim 3
Dependent Claim
20 words
A powdery pharmaceutical composition as claimed in claim 1, wherein the polypeptide has a molecular weight of 300 to 300,000.
Claim 4
Dependent Claim
31 words
A powdery pharmaceutical composition as claimed in claim 1, wherein the polypeptide is at least one member selected from the group consisting of peptide hormones, physiologically active proteins, zymoproteins, and vaccines.
Claim 5
Dependent Claim
26 words
4 . A powdery pharmaceutical composition as claimed in claim 3, wherein the peptide hormones include calcitonin, insulin luteinzing hormone-refeasing hormones, desmopressin, vasopressin, oxytocin, and inteferons.
Claim 6
Dependent Claim
38 words
A powdery pharmaceutical composition as claimed in claim 1, wherein the quaternary ammonium compound is at least one member selected from the group consisting of benzalkonium chloride, benzethonium chloride, cetyl trimethyl ammonium bromide, and dodecyl dimethyl ammonium bromide.
Claim 7
Dependent Claim
19 words
A powdery pharmaceutical composition as claimed in claim 5, wherein the quaternary ammonium compound is benzalkonium chloride or.benzethonium chloride.
Claim 8
Dependent Claim
37 words
A powdery pharmaceutical composition as claimed in claim 1, wherein the lower alkyl ether of cellulose is at least one member selected from the group consisting of hydrox- yproyl cellulose, methyl cellulose, hydroxyethyl cellulose, and hydroxypropylmethyl cellulse.
Claim 9
Dependent Claim
19 words
A powdery pharmaceutical composition as claimed in claim 7, wherein the lower alkyl ether of cellulse is hydroxypropyl cellulose.
Claim 10
Dependent Claim
35 words
A powdery pharmaceutical composition as claimed in claim 1, wherein the quatemaly ammonium compound is included therein in an amount of about 0.001% to 12% by weight based on the total weight of the composition.
Claim 11
Dependent Claim
61 words
A powdery pharmaceutical composition of claim 1, wherein the composition is prepared by mixing (i) a lyophilized mixture of the polypeptide having a physiological activity, a portion or total amount of the quaternary ammonium compound, and a portion of the lower alkyl ether of cellulose, (ii) the remainder of the lower alkyl ether of cellulose, and, optionally (iii) the quaternary ammonium.
Claim 12
Dependent Claim
36 words
A powdery pharmaceutical composition as claimed in claim 10, wherein the amount of the component (ii) is 0.01% to 10% by weight of the total amount of the lower alkyl ether of cellulose in the composition.
Claim 13
Dependent Claim
35 words
A powdery pharmaceutical composition as claimed in claim 1, wherein at least about 90% by weight of the powder particles of the pharmaceuticat composition has an effective particle diameter of about 10 to 250 µm.
Claim 14
Dependent Claim
25 words
A powdery pharmaceutical preparation in unit dosage form for application to the mucosa of the nasal cavity comprising the powdery pharmaceutical composition of claim 1.
Claim 15
Dependent Claim
19 words
A powdery pharmaceutical preparation as claimed in claim 1 3, wherein the pharmaceutical composition is included in a capsule.
References Cited (Backward Citations)
No citation records indexed.
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