Patent EP0188920A2 successfully refreshed from Google Patents.
EP0188920A2
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EP
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Interleukin 1 and its derivative
Assignee: Sumitomo Pharma Co Ltd
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Filing: 1985-12-23
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Granted: —
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Expires: 2005-12-23
Abstract
Abstract DNAs encoding polypeptides having interleukin 1, vectors inserted with said DNAs, hosts transformed with said recombinant vectors, polypeptides having interleukin 1 activity which are produced by cultivation of the transformed hosts, derivatives of the polypeptides, pharmaceutical composition containing said polypeptides or derivatives, their use as an antitumor or antiinfectious agent, and processes for the preparation thereof.
Inventors
- 👤 Masaaki Yamada
- 👤 Yasuji Furutani
- 👤 Michiko Yamayoshi
- 👤 Mitsue Notake
- 👤 Junichi Yamagishi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-10 01:14
CPC Classifications
C; C12; C12N; C12N15/00; C07; C07K; C07K14/00; C07K14/435; C07K14/52; C07K14/54; C07K14/545; A; A61; A61K; A61K38/00; Y; Y02; Y02A; Y02A50/00; Y02A50/30; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/14; Y10S930/141
Claims Analysis
Total Claims: 42
Claim 1
Independent Claim
16 words
A DNA having or containing a nucleotide sequence coding for a polypeptide possessing interleukin 1 activity.
Claim 2
Dependent Claim
16 words
A DNA having or containing a nucleotide sequence coding for a polypeptide possessing interleukin 1 activity.
Claim 3
Dependent Claim
19 words
A DNA according to claim 1, wherein the nucleotide sequence is derived from human interleukin 1 gene or cDNA.
Claim 4
Dependent Claim
19 words
A DNA according to claim 1, wherein the nucleotide sequence is derived from rabbit interleukin 1 gene or cDNA.
Claim 5
Dependent Claim
32 words
A DNA according to claim 2, wherein the nucleotide sequence corresponds to an amino acid sequence represented by the formula [I-1] shown in the attached Table 1-1 or its modified nucleotide sequence.
Claim 6
Dependent Claim
50 words
A DNA according to claim 2, wherein the nucleotide sequence corresponds to an amino acid sequence represented by the formula CI-1] shown in the attached Table 1-1 in which one to sixteen amino acid residues at the N-terminus and/or one to seven amino acid residues at the C-terminus are deleted.
Claim 7
Dependent Claim
50 words
A DNA according to claim 2, wherein the nucleotide sequence corresponds to an amino acid sequence represented by the formula [1-1] shown in the attached Table 1-1 in which one to fifteen amino acid residues at the N-terminus and/or one to five amino acid residues at the C-terminus are deleted.
Claim 8
Dependent Claim
65 words
A DNA according tc claim 2, wherein the nucleotide sequence corresponds to an amino acid sequence represented by the formula [I-1] shown in the attached Table 1-1 which nucleotide sequence at the 5'-terminus has a nucleotide sequence corresponding to an amino acid sequence represented by the formula [I-2] shown in the attached Table 2-1 in which amino acid residue(s) at the N-terminus may be deleted.
Claim 9
Dependent Claim
41 words
A DNA according to claim 2, wherein the nucleotide sequence corresponds to an amino acid sequence represented by the formula [1-1] shown in the attached Table 1-1, in which two, ten or fifteen amino acid residues at the N-terminus are deleted.
Claim 10
Dependent Claim
40 words
A DNA according to claim 2, wherein the nucleotide sequence corresponds to an amino acid sequence represented by the formula [1-1] shown in the attached Table 1-1, in which four or five amino acid residues at the C-terminus are deleted.
Claim 11
Dependent Claim
46 words
A DNA according to claim 2, wherein the nucleotide sequence corrsponds to an amino acid sequence represented by the formula [I-1] shown in the attached Table 1-1 in which fifteen amino acid residues at the N-terminus and four amino acid residues at the C-terminus are deleted.
Claim 12
Dependent Claim
66 words
A DNA according to claim 2, wherein the nucleotide sequence corresponds to an amino acid sequence represented by the formula [1-1] shown in the attached Table 1-1 which nucleotide sequence at the 5'-terminus has a nucleotide sequence corresponding to an amino acid sequence represented by the formula [1-2] shown in the attached Table 2-1 in which sixty two amino acid residue at the N-terminus are deleted.
Claim 13
Dependent Claim
27 words
A DNA according to claim 3, wherein the nucleotide sequence corrsponds to an amino acid sequence representaed by the formula [A-1] shown in the attached Table 3-1.
Claim 14
Dependent Claim
65 words
A DNA according to claim 3, wherein the nucleotide sequence corresponds to an amino acid sequence represented by the formula [A-1] shown in the attached Table 3-1 which nucleotide sequence at the 5'-terminus has a nucleotide sequence corresponding to an amino acid sequence represented by the formula [A-2] shown in the attached Table 4-1 in which amino acid residue(s) at the N-terminus may be deleted.
Claim 15
Dependent Claim
34 words
A DNA having or containing a nucleotide sequence as set forth in claim 4, 5, 6, 8, 9, 10, 11 or 12 which has an intiation codon at the 5'-terminus of said nucleotide sequence.
Claim 16
Dependent Claim
19 words
A vector into which the DNA as set forth in any one of claims 1 to 14 is inserted.
Claim 17
Dependent Claim
11 words
The vector according to claim 15 which is an expression vector.
Claim 18
Dependent Claim
52 words
An expression vector according to claim 16 which comprises a DNA having or containing a nucleotide sequence as set forth in any one of claims 4 tc 14 and having a termination codon(s) at the 3'-terminus of said nucleotide sequence, wherein said nucleotide sequence is under the control of a transcriptional promoter.
Claim 19
Dependent Claim
15 words
An expression vector according to claim 17 wherein the transcriptional promoter is a trp promoter.
Claim 20
Dependent Claim
17 words
A vector accoding to any one of claims 15 to 18 which can proliferate in Escherichia coli.
Claim 21
Dependent Claim
11 words
A vector according to claim 19 which is Escherichia coli plasmid.
Claim 22
Dependent Claim
11 words
A vector according to claim 20 which is pBR322 or pBRS6.
Claim 23
Dependent Claim
15 words
A host trasformed with the vector as set any one of claims 15 to 21.
Claim 24
Dependent Claim
9 words
A host according to claim 22 which is microorganism.
Claim 25
Dependent Claim
10 words
A host according to claim 23 which is Escherichia coli.
Claim 26
Dependent Claim
9 words
A polypeptide possessing interleukin 1 activity or its derivative.
Claim 27
Dependent Claim
9 words
A polypeptide possessing interleukin 1 activity or its derivative.
Claim 28
Dependent Claim
19 words
A polypeptide according to claim 25 which is derived from human interleukin 1 gene or cDNA or its derivative.
Claim 29
Dependent Claim
19 words
A polypeptide according to claim 25 which is derived from rabbit interleukin 1 gene or cDNA or its derivative.
Claim 30
Dependent Claim
27 words
A polypeptide according to claim 26 which has an amino acid sequence represented by the formula [1-1] shown in the attached Table 1-1 or its modified polypeptide.
Claim 31
Dependent Claim
46 words
A polypeptide according to claim 26 which has an amino acid sequence represented by the formula [I-1] shewn in the attached Table 1-1 in which one to sixteen amino acid residues at the N-terminus and/or one to seven amino acid residues at the C-terminus are deleted.
Claim 32
Dependent Claim
46 words
A polypeptide according to claim 26 which has an amino acid sequence represented by the formula [I-1] shown in the attached Table 1-1 in which one to fifteen amino acid residues at the N-terminus and/or one to five amino acid residues at the C-terminus are deleted.
Claim 33
Dependent Claim
37 words
A polypeptide according to claim 26 which has an amino acid sequence represented by the formula [I-1] shewn in the attached Table 1-1, in which two, ten or fifteen amino acid residues at the N-terminus are deleted.
Claim 34
Dependent Claim
36 words
A polypeptide according to claim 26 which has an amino acid sequence represented by the formula [I-1] shcwn in the attached Table 1-1, in which four or five amino acic residues at the C-terminus are deleted.
Claim 35
Dependent Claim
42 words
A polypeptide according to claim 26 which has an amino acid sequence represented by the formula [I-1] shown in the attached Table 1-1 in which fifteen amino acid residues at the N-terminus and four amino acid residues at the C-terminus are deleted.
Claim 36
Dependent Claim
23 words
A polypeptide according to claim 27 which has an amino acid sequence represented by the formula [A-1] shown in the attached Table 3-1.
Claim 37
Dependent Claim
30 words
A polypeptide having an amino acid sequence as set forth in any one of claims 28 to 34 which has methionine residue at the N-terminus of said amino acid sequence.
Claim 38
Dependent Claim
22 words
A substance resulting from chemical or enzymatic modification of the polypeptide as set forth in any one of claims 29 to 35.
Claim 39
Dependent Claim
18 words
A pharmaceutically acceptable salt of a polypetide as set forth in any one of claims 28 to 36.
Claim 40
Dependent Claim
21 words
An aggregate having a polypeptide as set forth in any one of claims 26 to 36 in admixture as a subunit.
Claim 41
Dependent Claim
33 words
A pharmaceutical composition of comprising as an active ingredient a polypeptide or substance as set forth in any one of claims 26 to 38 as in amixture with a conventional carrier or diluent.
Claim 42
Dependent Claim
25 words
Use of any one of the polypeptides or substances and compositions as set forth in claims 26 to 39 as an antitumor or antiinfections agent.
References Cited (Backward Citations)
No citation records indexed.
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