EP0168093A1
Expired / Lapsed
EP
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Binder for low density lipoproteins
Assignee: Biomerieux BV
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Filing: 1985-06-20
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Granted: —
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Expires: 2005-06-20
Abstract
Abstract A binder for low density lipoproteins (LDL) consisting of sulphated polyvinyl alcohol which is cross-linked by the chemical or the physical route to a waterinsoluble product. The binder may be in the form of a hydrogel which is applied or not to a carrier or it may be present on the surface of a polyvinyl alcohol fibre which is preferably in the form of tape having a thickness of 0,1 to 2 µm and a width of 0, 5 to 6 µm. The fibre shaped binder is prepared by successively cross-linking with an acidified aqueous solution of glutardialdehyde and sulphating with chlorosulphonic acid.
Inventors
- 👤 Nico Maaskant
- 👤 Adriaan Bantjes
- 👤 Hermanus Johannes Marie Kempen
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 16:53
CPC Classifications
C; C08; C08J; C08J3/00; C08J3/28; A; A61; A61P; A61P3/00; A61P3/06; C08F; C08F8/00; C08F8/18; C08F8/28; C08F8/34; C08F8/36; C08F2810/00; C08F2810/20; C08J2329/00; C08J2329/02; C08J2329/04; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/104165; Y10T436/106664
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
23 words
A binder for low density lipoproteins (LDL) consisting of. sulphated polyvinyl alcohol, characterized in that the polymer is cross-linked to a waterinsoluble product.
Claim 2
Dependent Claim
23 words
A binder for low density lipoproteins (LDL) consisting of. sulphated polyvinyl alcohol, characterized in that the polymer is cross-linked to a waterinsoluble product.
Claim 3
Dependent Claim
19 words
A binder according to claim 1, characterized in that at least 20% of the vinyl alcohol groups is sulphated.
Claim 4
Dependent Claim
19 words
A binder according to claim 1, characterized in that at least 50% of the vinyl alcohol groups is sulphated.
Claim 5
Dependent Claim
19 words
A binder according to claim 1, characterized in that at least 65% of the vinyl alcohol groups is sulphated.
Claim 6
Dependent Claim
25 words
A binder according to claim 1, characterized in that binder is in the form of a hydrogel which is applied or not to a carrier.
Claim 7
Dependent Claim
35 words
A binder according to claim 1, characterized in that it is so cross-linked that after swelling in a physiological salt solution the weight ratio of swollen gel to dry matter is 10 to 75 g/g.
Claim 8
Dependent Claim
35 words
A binder according to claim 1, characterized in that it is so cross-linked that after swelling in a physiological salt solution the weight ratio of swollen gel to dry matter is 30 to 50 g/g.
Claim 9
Dependent Claim
20 words
A binder according to claim 1, characterized in that it is present on the surface of a polyvinyl alcohol fibre.
Claim 10
Dependent Claim
33 words
A binder according to claim 8, characterized in that the fibre is in the form of tape, and has a thickness of 0,1 to 2µm and a width of 0,5 to 6 µm.
Claim 11
Dependent Claim
32 words
10 A process for preparing a low density lipoproteins (LDL) binder by sulphating a polyvinyl alcohol, characterized in that before or after sulphation the polyvinyl alcohol is cross-linked to a waterinsoluble product.
Claim 12
Dependent Claim
32 words
10 A process for preparing a low density lipoproteins (LDL) binder by sulphating a polyvinyl alcohol, characterized in that before or after sulphation the polyvinyl alcohol is cross-linked to a waterinsoluble product.
Claim 13
Dependent Claim
73 words
11 A process according to claim 10, characterized in that the polyvinyl alcohol is successively sulphated to a degree of sulphation of 0,23 to 0,96, dissolved in water to a polymer concentration of 10 to 70 per cent by weight, and the resulting product is cross-linked by the chemical route or subjected to a γ-radiation dose of 0,5 to 25 x 10 4 Gy and preferably of 2,5 to 10,0 x 10" Gy.
Claim 14
Dependent Claim
26 words
12 A process for the manufacture of a fibre shaped binder according to claim 8, characterized in that the fibre polymer is successively cross-linked and sulphated.
Claim 15
Dependent Claim
67 words
13 A process according to claim.12, characterized in that the fibre polymer is cross-linked by steeping the fibre in an acidified aqueous solution of glutardialdehyde, followed by washing with water and drying, sulphating with chlorosulphonic acid, washing to remove excess of chlorosulphonic acid, steeping in an aqueous sodium hydroxide solution and finally washing successively with water, a physiological buffer solution, and water, followed by drying, if required.
References Cited (Backward Citations)
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