Patent EP0167127A2 successfully refreshed from Google Patents.
EP0167127A2
Expired / Lapsed
EP
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Method of localizing NMR chemical shift information by depth-resolved coil spectroscopy, and apparatus therefor
Assignee: OFFERTA DI LICENZA AL PUBBLICO
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Filing: 1985-06-28
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Granted: —
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Expires: 2005-06-28
Abstract
Abstract A method for obtaining spatially resolved nuclear magnetic resonance chemical shift spectra, by depth-resolved surface coil spectroscopy (DRESS), substantially eliminates surface tissue contamination of the chemical shift spectra by employing selective excitation in the presence of a gradient magnetic field directed coaxial with the axis of a surface coil. The nuclei in a disk-shaped preselected volume are excited by a selective radio-frequency signal pulse applied in the presence of the gradient field. The surface coil is always utilized for receiving magnetic resonance response signals, while the same surface coil, or a separate transmitting antenna, can be used to provide the radio-frequency excitation field across the selected disk-shaped volume. The technique can be combined with conventional 90°-τ-180° or 180°-τ-90° relaxation time measurement RF pulse sequences, or with a solvent suppression NMR spectroscopy technique employing selective excitation.
Inventors
- 👤 Paul Arthur Bottomley
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-31 22:34
CPC Classifications
G; G01; G01N; G01N24/00; G01N24/08; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/483; G01R33/4831
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
166 words
A method for obtaining spatially resolved nuclear magnetic resonance chemical shift spectra from a selected. volume portion of a sample, comprising the steps of: (a) providing a static magnetic field in a first direction through at least the selected sample volume; (b) providing a surface coil having a plane positioned substantially parallel to the plane of the selected sample volume to be imaged; (c) temporarily exciting at least the selected sample volume with a radio-frequency (RF) magnetic field; (d) providing, during the presence of the RF field, the static magnetic field with a magnetic field gradient in a direction substantially perpendicular to the surface coil plane; (e) adjusting the frequency of the RF field and the magnitude of the magnetic field gradient to selectively excite the nuclei in the selected sample volume, at a predetermined distance from the surface coil plane; and (f) receiving, with the surface coil, the response signal emitted from the nuclei in the selectively- excited sample volume, for obtaining imaging information therefrom.
Claim 2
Independent Claim
166 words
A method for obtaining spatially resolved nuclear magnetic resonance chemical shift spectra from a selected. volume portion of a sample, comprising the steps of: (a) providing a static magnetic field in a first direction through at least the selected sample volume; (b) providing a surface coil having a plane positioned substantially parallel to the plane of the selected sample volume to be imaged; (c) temporarily exciting at least the selected sample volume with a radio-frequency (RF) magnetic field; (d) providing, during the presence of the RF field, the static magnetic field with a magnetic field gradient in a direction substantially perpendicular to the surface coil plane; (e) adjusting the frequency of the RF field and the magnitude of the magnetic field gradient to selectively excite the nuclei in the selected sample volume, at a predetermined distance from the surface coil plane; and (f) receiving, with the surface coil, the response signal emitted from the nuclei in the selectively- excited sample volume, for obtaining imaging information therefrom.
Claim 3
Dependent Claim
67 words
The method of Claim 1, further comprising the steps of: fabricating the surface coil to have a substantially circular shape and a predetermined radius A; and selecting the disk-shaped volume to be imaged to be at a distance D between about zero and about A from the plane of the surface coil and with a center substantially along a line through the center of the surface coil.
Claim 4
Dependent Claim
32 words
The method of Claim 1, wherein step (c) comprises the step of: selectively exciting the sample with a substantially 90° selective RF signal pulse during the presence of the magnetic field gradient.
Claim 5
Dependent Claim
30 words
The method of Claim 3, wherein step (c) further comprises the step of: modulating the RF signal to selectively excite a volume of a predetermined thickness T of said sample.
Claim 6
Dependent Claim
22 words
The method of Claim 4, wherein step (c) further comprises the step of: modulating the RF signal to have a Gaussian envelope.
Claim 7
Dependent Claim
28 words
The method of Claim 4, wherein step (c) further comprises the step of: modulating the RF signal to have a (sin bt)/bt, where b is a constant, envelope.
Claim 8
Dependent Claim
43 words
The method of Claim 3, further comprising the step of: providing the static magnetic field, immediately after the cessation of the RF field, with a rephasing field gradient portion of polarity opposite to the polarity of the magnetic field gradient of step (d).
Claim 9
Dependent Claim
27 words
The method of Claim 3, further comprising the step of: utilizing the single surface coil for transmitting the exciting RF field and for receiving the response signal.
Claim 10
Dependent Claim
38 words
The method of Claim 3, wherein step (c) further comprises the step of: providing one of a volume coil and another surface coil, different from the surface coil receiving the response signal, for selectively-exciting the selected sample volume.
Claim 11
Dependent Claim
46 words
The method of Claim 9, wherein the exciting RF signal is applied with another surface coil, and further comprising the step of: selecting the radius R' of the another surface coil to be greater than the radius A of the surface coil receiving the response signal.
Claim 12
Dependent Claim
38 words
The method of Claim 9, wherein another surface coil is utilized for transmitting the RF exciting signal, and further comprising the step of: adapting the surface coil and the another surface coil to substantially minimize RF interaction between.
Claim 13
Dependent Claim
30 words
The method of Claim 11, further comprising the step of: positioning the plane of the another surface coil to be substantially parallel to the plane of the receiving surface coil.
Claim 14
Dependent Claim
42 words
The method of Claim 1, wherein step (c) comprises the step of: sequentially providing a substantially 90° RF signal pulse and a substantially 180° RF signal pulse, separated by a selected time interval, for acquiring spin-echo imaging response signals in step (f).
Claim 15
Dependent Claim
21 words
The method of Claim 13, wherein the receiving surface coil is also utilized for transmitting the exciting RF signal pulse sequence.
Claim 16
Dependent Claim
48 words
The method of Claim 14, further comprising the steps of: utilizing the 90° RF signal pulse as a selective pulse present at least during a portion of the time during which the magnetic field gradient is present; and providing the 180° RF signal pulse as a nonselective pulse.
Claim 17
Dependent Claim
57 words
. 16. The method of Claim 15, further comprising the step of: providing, in the time interval between the end of the 90° selective RF signal pulse and the beginning of the following 180° nonselective RF signal pulse, a magnetic field gradient of polarity opposite to the polarity of the magnetic field gradient provided in step (d).
Claim 18
Dependent Claim
22 words
The method of Claim 15, further comprising the step of: modulating the 90° selective RF signal pulse with a substantially Gaussian envelope.
Claim 19
Dependent Claim
30 words
The method of Claim 15, further comprising the step of: modulating the 90° selective RF signal pulse with an envelope having a (sin bt)/bt, where b is a constant, shape.
Claim 20
Dependent Claim
62 words
The method of Claim 14, wherein step (c) comprises the steps of: exciting the selected volume with a substantially 180° RF signal pulse; and then exciting the selected volume with a substantially 90° selective RF signal pulse during the presence of the magnetic field gradient and commencing at a predetermined time interval after the commencement of the substantially 180° RF signal pulse.
Claim 21
Dependent Claim
22 words
The method of Claim 19, further comprising the step of: modulating the substantially 90° selective RF signal pulse with a Gaussian envelope.
Claim 22
Dependent Claim
30 words
The method of Claim 19, further comprising the step of: modulating the selective 90° RF signal pulse with an envelope having a (sin bt)/bt, where b is a constant, shape.
Claim 23
Dependent Claim
45 words
The method of Claim 13, further comprising the step of: utilizing a selected one of a volume coil and a second surface coil, different than the receiving surface coil, for applying at least a portion of the sample volume exciting RF field of step (c).
Claim 24
Dependent Claim
74 words
The method of Claim 22, further comprising the steps of: applying a substantially 90° selective RF pulse to the sample volume from the receiving surface coil during the presence of the depth-selecting magnetic field gradient; and applying a substantially 180° non-selective RF signal pulse, commencing at a selected time interval t after the commencement of the substantially 90° RF signal pulse, to the selected one of the volume coil and the second surface coil.
Claim 25
Dependent Claim
17 words
The method of Claim 23, wherein the selective RF signal pulse is modulated with a Gaussian envelope.
Claim 26
Dependent Claim
27 words
2 5. The method of Claim 23, wherein the selective RF signal pulse is modulated with an envelope having a (sin bt)/bt, where-b is a constant, shape.
Claim 27
Dependent Claim
62 words
The method of Claim 22, wherein step (c) comprises the steps of: exciting the selected volume with a substantially 180° RF signal pulse; and then exciting the selected volume with a substantially 90° selective RF signal pulse during the presence of the magnetic field gradient and commencing at a predetermined time interval after the commencement of the substantially 180° RF signal pulse.
Claim 28
Dependent Claim
22 words
The method of Claim 26, further comprising the step of: modulating the substantially 90° selective RF signal pulse with a Gaussian envelope.
Claim 29
Dependent Claim
30 words
The method of Claim 26, further comprising the step of: modulating the selective 90° RF signal pulse with an envelope having a (sin bt)/bt, where b is a constant, shape.
Claim 30
Dependent Claim
22 words
The method of Claim 1, further comprising the step of: sequentially repeating steps (c)-(f) to obtain at least one additional response signal.
Claim 31
Dependent Claim
46 words
The method of Claim 26, wherein step (c) further comprises the steps of: repeatedly applying the RF field by transmission of a selective RF signal pulse; and alternating the phase of the selective RF signal pulse for each repetition of the excitation-response sequence of steps (c)-(f).
Claim 32
Dependent Claim
41 words
The method of Claim 27, wherein the RF field excitation sequence of step (c) utilizes both 90° and 180° RF signal pulses, and further comprises the step of: phase- alternating either, but not both, of the pulses in an excitation sequence.
Claim 33
Dependent Claim
52 words
The method of Claim 1, wherein step (c) further comprises the step of: selectively exciting a selected chemically shifted species in the sample using a second selective RF signal pulse applied, in the absence of spatially selective magnetic field gradients, prior to exciting the selected volume in the presence of the gradient.
Claim 34
Dependent Claim
33 words
The method of Claim 32, further comprising the step of: adjusting the second selective RF signal pulse to suppress the response signal from the selected chemically shifted species detected with the surface coil.
Claim 35
Dependent Claim
66 words
The method of Claim 33, wherein the adjusting step comprises the steps of: adjusting the amplitude of the chemically selective pulse signal to cause the total of the RF pulses experienced by said chemically selected nuclei in said selective sample to be an integral multiple of 180°; and adjusting the bandwidth of the chemically selective pulse signal to cause only the selected species to be suppressed.
Claim 36
Dependent Claim
31 words
The method of Claim 32, wherein the second selective RF signal pulse consists of a substantially Gaussian modulated RF pulse with RF frequency centered on the chemical species to be suppressed.
Claim 37
Dependent Claim
31 words
The method of Claim 32, wherein the second selective RF signal pulse consists of a substantially (sin bt)/bt-modulated RF pulse with RF frequency centered on the chemical species to be suppressed.
References Cited (Backward Citations)
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