Patent EP0166559A2 successfully refreshed from Google Patents.
EP0166559A2
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EP
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Method and apparatus for obtaining localised nmr spectra
Assignee: Oxford Research Systems Ltd
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Filing: 1985-06-14
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Granted: —
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Expires: 2005-06-14
Abstract
Abstract A method of obtaining an NMR spectrum from a first region lying wholly within a second region of a sample material, comprises obtaining a signal indicative of a first NMR spectrum from substantially all of the second region of the sample material applying to the sample a magnetic field gradient, and simultaneously applying to the sample an Rf perturbing pulse having an amplitude and a frequency distribution such as to perturb nuclear spins in the said first region, but not outside it, removing the magnetic field gradient, and thereafter obtaining from the sample a signal indicative of a second NMR spectrum before relaxation of the perturbed spins in the said first region, and comparing the said first and second signals to obtain a difference spectrum attributable to the said region. Three separate perturbing pulses are preferably employed, each in the presence of a corresponding field gradient. The experiment is preferably repeated a large number of times, with the Rf carrier frequency stepped between each Rf pulse (for example every 500 microseconds).
Inventors
- 👤 Roger J. Ordidge
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-07 13:01
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/483; G01R33/485
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
132 words
A method of obtaining an NMR spectrum from a first region lying wholly within a second region of a sample material, which method comprises obtaining a signal indicative of a first NMR spectrum from substantially all of the second region of the sample material, applying to the sample a magnetic field gradient, and simultaneously applying to the sample an Rf perturbing pulse having an amplitude and a frequency distribution such as to perturb nuclear spins in the said first region, but not outside it, removing the magnetic field gradient, and thereafter obtaining from the sample a signal indicative of a second NMR spectrum before relaxation of the perturbed spins in the said first region, and comparing the said first and second signals to obtain a difference spectrum attributable to the said region.
Claim 2
Independent Claim
132 words
A method of obtaining an NMR spectrum from a first region lying wholly within a second region of a sample material, which method comprises obtaining a signal indicative of a first NMR spectrum from substantially all of the second region of the sample material, applying to the sample a magnetic field gradient, and simultaneously applying to the sample an Rf perturbing pulse having an amplitude and a frequency distribution such as to perturb nuclear spins in the said first region, but not outside it, removing the magnetic field gradient, and thereafter obtaining from the sample a signal indicative of a second NMR spectrum before relaxation of the perturbed spins in the said first region, and comparing the said first and second signals to obtain a difference spectrum attributable to the said region.
Claim 3
Dependent Claim
26 words
A method as claimed in Claim 1, wherein the Rf pulse is such as to produce in the said first region spin nutation of approximately 180°.
Claim 4
Dependent Claim
37 words
A method as claimed in Claim 1 or Claim 2, wherein a surface coil is utilised as the antenna either for the Rf perturbing pulse, or for acquisition of signal to obtain the NMR spectrum, or both.
Claim 5
Dependent Claim
45 words
A method as claimed in Claim 1, wherein the said method is repeated a plurality of times using different Rf pulse distributions, and the NMR spectrum of each of a plurality of said first regions is obtained by applying difference techniques to the signals obtained.
Claim 6
Dependent Claim
27 words
A method as claimed in Claim 4, wherein the Rf carrier frequency is changed between subsequent repetitions, within a time period of not greater than 10 milliseconds.
Claim 7
Independent Claim
67 words
A method as claimed in any one of the preceding claims, wherein a first Rf perturbing pulse is applied in the presence of a magnetic field gradient in a first direction, a second Rf perturbing pulse is subsequently applied in the presence of a magnetic field gradient in a second direction, orthogonal to the first direction, and both gradients are removed prior to the NMR signal acquisition.
Claim 8
Dependent Claim
55 words
A method as claimed in Claim 6, wherein a third Rf perturbing pulse is applied subsequently to the second Rf perturbing pulse, in the presence of a magnetic field gradient in a third direction, orthogonal to the said first and second directions, and the said third gradient is removed prior to the NMR signal acquisition.
Claim 9
Dependent Claim
202 words
Apparatus for obtaining an NMR spectrum from a first region lying wholly within a second region 3 f a sample material, which apparatus comprises means for supporting a sample in a substantially homogeneous magnetic field, means for applying to the sample a first signal acquisition Rf pulse, and acquiring from the sample a first signal, indicative of the NMR spectrum of a said second region of the sample, means for superimposing on the magnetic field a field gradient in a first direction, means for applying to the sample in the presence of the said gradient a first Rf conditioning pulse having an amplitude and frequency distribution such as to perturb nuclear spins only in a said first region lying wholly within the said second region, means for removing the gradient and immediately thereafter applying to the sample a second signal aquisition pulse, and acquiring from the sample a second signal, indicative of the NMR spectrum of the said second region of the sample after the application of the said Rf conditioning pulse, but in the absence of applied field gradient, and means for comparing the said first and second signals, to obtain an NMR spectrum due only to a said first region.
Claim 10
Dependent Claim
202 words
Apparatus for obtaining an NMR spectrum from a first region lying wholly within a second region 3 f a sample material, which apparatus comprises means for supporting a sample in a substantially homogeneous magnetic field, means for applying to the sample a first signal acquisition Rf pulse, and acquiring from the sample a first signal, indicative of the NMR spectrum of a said second region of the sample, means for superimposing on the magnetic field a field gradient in a first direction, means for applying to the sample in the presence of the said gradient a first Rf conditioning pulse having an amplitude and frequency distribution such as to perturb nuclear spins only in a said first region lying wholly within the said second region, means for removing the gradient and immediately thereafter applying to the sample a second signal aquisition pulse, and acquiring from the sample a second signal, indicative of the NMR spectrum of the said second region of the sample after the application of the said Rf conditioning pulse, but in the absence of applied field gradient, and means for comparing the said first and second signals, to obtain an NMR spectrum due only to a said first region.
Claim 11
Dependent Claim
29 words
Apparatus as claimed in Claim 8, including means for repeating rapidly the said sequence of Rf pulses and signal acquisition and for averaging the signals obtained from repeated acquisitions.
Claim 12
Dependent Claim
19 words
Apparatus as claimed in Claim 9, including means for varying rapidly the Rf carrier frequency between successive Rf pulses.
Claim 13
Dependent Claim
38 words
Apparatus as claimed in Claim 10, wherein the said means for varying the carrier frequency is capable of varying the carrier frequency and applying a further Rf pulse within a time period of not greater than 10 milliseconds.
Claim 14
Dependent Claim
16 words
Apparatus as claimed in Claim 11, wherein the said period is not greater than 50 microseconds.
Claim 15
Dependent Claim
170 words
Apparatus as claimed in any one of Claims 8 to 12, including, means for superimposing on the magnetic field subsequently to the superimposition of the field gradient in the said first direction a magnetic field gradient in a second direction, orthogonal to the first direction, means for applying to the sample in the presence of the field gradient in the second direction a second Rf conditioning pulse having an amplitude and frequency distribution such as to perturb nuclear spins only in a third region of the said sample, means for acquiring from the sample in the absence of applied field gradient signals indicative of the NMR spectrum of the sample with no Rf conditioning pulse applied, after the application of the first and second Rf conditioning pulses separately, and after the application of the first and second Rf conditioning pulses together, and means for comparing the various signals obtained so as to derive therefrom the NMR spectrum attributable only to the overlapping portions of the said first and third regions.
Claim 16
Dependent Claim
154 words
Apparatus as claimed in Claim 13, including means for superimposing on the magnetic field, subsequently to the superimposition of the magnetic field in the second direction, a magnetic field in a third direction, orthogonal to both the first and second directions, means for applying to the sample in the presence of the said gradient in the third direction a third Rf conditioning pulse having an amplitude and frequency distribution such as to perturb nuclear spins only in a fourth region, means for acquiring from the sample in the absence of applied field gradient signals indicative of the NMR spectrum of the sample with no Rf conditioning pulse applied, and with each of the seven possible combinations of the said first, second and third Rf conditioning pulses, means for comparing the signals obtained so as to derive therefrom an NMR spectrum attributable only to the overlapping portions of the said first, third and fourth regions.
Claim 17
Dependent Claim
61 words
Apparatus as claimed in Claim 14, including means for applying to the sample in the presence of one of the said gradients a plurality of Rf pulses of different Rf carrier frequency, thereby to obtain on comparison of the said obtained signals, an NMR signal attributable only to nuclei in a column orientated in the direction of the said one gradient.
Claim 18
Dependent Claim
59 words
Apparatus as claimed in Claim 14 or Claim 15, including means for obtaining a signal indicative of an NMR spectrum from a plurality of regions or columns of the object, and for summing the said signals, so as to obtain an NMR spectrum of a region of the object composed of a plurality of said small regions or columns.
Claim 19
Dependent Claim
42 words
Apparatus as claimed in any one of Claims 8 to 16, wherein the means for supporting the sample includes means for supporting a human body with at least a portion of the body in the said homogeneous region of the magnetic field.
References Cited (Backward Citations)
No citation records indexed.
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