Patent US3337845A successfully refreshed from Google Patents.
Patent EP0164896A1 successfully refreshed from Google Patents.
EP0164896A1
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EP
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Percutaneous access device
Assignee: Thermo Fisher Scientific Inc
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Filing: 1985-05-09
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Granted: —
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Expires: 2005-05-09
Abstract
Abstract A percutaneous access device (PAD) (20) for long-term skin penetration and use as an access port in the body of a patient includes a flat skirt (22) for a subdermal anchoring of the PAD and a neck (24) through which a tube (56) may extend for transmission of materials to or from the body. A two-stage porous bed (32) covers the skirt (22) and at least a portion of the neck (24) and promotes formation of a tight, infection-free barrier between the percutaneous access device (20) and adjacent tissues, stabilizing the device (20) for long-term use. The first stage (34) of the bed (32) retards downgrowth of epidermal cells for a time sufficient for mature collagen to form in the second stage (40), thereby permitting the tight dermallbiomaterial interface or barrier to form at a location near the junction (36) of the two stages.
Inventors
- 👤 Victor L. Poirier
- 👤 Warren C. Clay
- 👤 Benedict D. T. Daly
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 12:45
CPC Classifications
A; A61; A61M; A61M39/00; A61M39/02; A61M39/0247; A61L; A61L29/00; A61L29/04; A61L29/041; A61L29/06; A61F; A61F2250/00; A61F2250/0014; A61F2250/0023; A61M2039/0261; A61M2039/0294
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
190 words
A percutaneous access device for implantation in humans or animals, characterised in that it comprises:- a main body including a substantially flat, disk-shaped skirt (22, 62) and a neck (24, 64) integral with and substantially normal to said skirt (22, 62), said neck (24, 64) and skirt being formed of a biocompatible polyurethane and including a bore - (28, 66) therethrough to accommodate a tube (56, 76). a first porous bed (34, 68) surrounding and attached to a lower portion of the neck (24, 64) and extending along a portion of the surface of the skirt (22, 62) adjacent the neck (24, 64) the first porous bed (34, 68) including a multiplicity of interconnected pores having a size such that upon implantation of the skirt (22, 64) just below the dermis, the pores permit downgrowth of epidermal cells through the bed at a controlled rate; and a second porous bed (40, 70) forming a junction (36, 88) on the skirt (22, 64) with one end of the first bed (34, 68) and including pores sufficiently larger than the pores of the first bed (34, 68) to permit infiltration of fibroblasts.
Claim 2
Dependent Claim
190 words
A percutaneous access device for implantation in humans or animals, characterised in that it comprises:- a main body including a substantially flat, disk-shaped skirt (22, 62) and a neck (24, 64) integral with and substantially normal to said skirt (22, 62), said neck (24, 64) and skirt being formed of a biocompatible polyurethane and including a bore - (28, 66) therethrough to accommodate a tube (56, 76). a first porous bed (34, 68) surrounding and attached to a lower portion of the neck (24, 64) and extending along a portion of the surface of the skirt (22, 62) adjacent the neck (24, 64) the first porous bed (34, 68) including a multiplicity of interconnected pores having a size such that upon implantation of the skirt (22, 64) just below the dermis, the pores permit downgrowth of epidermal cells through the bed at a controlled rate; and a second porous bed (40, 70) forming a junction (36, 88) on the skirt (22, 64) with one end of the first bed (34, 68) and including pores sufficiently larger than the pores of the first bed (34, 68) to permit infiltration of fibroblasts.
Claim 3
Dependent Claim
60 words
A device according to Claim 13, wherein the first bed (34) is formed of from three to ten layers of filaments of a polyurethane material, the filaments having a diameter in the range of from 0.004 to 0.015 inches (0.1 to 0.38 mm) and being spaced apart a distance of from 0.001 to 0.004 inches (0.025 to 0.1 m m).
Claim 4
Dependent Claim
62 words
A device according to Claim 1 or Claim 2, wherein the second bed (40) is formed of from three to ten layers of filaments of a polyurethane material, said filaments having a diameter in the range of from 0.004 to 0.015 inches (0.1 to 0.38 mm) and being spaced apart a distance of from 0.015 to 0.030 inches (0.38 to 0.76 mm).
Claim 5
Dependent Claim
25 words
A device according to Claim 1, in which the first bed (34) has pores of sizes in the range of from 50 to 125 microns.
Claim 6
Independent Claim
35 words
A device according to any one of Claims 1 to 4, wherein the first bed (34) has a path length along the neck (24) and skirt (22) of at least about 0.25 inches (6.4 mm).
Claim 7
Dependent Claim
25 words
A device according to Claim 4, wherein the first bed (34) has pores of a size in the range of from 75 to 125 microns.
Claim 8
Dependent Claim
18 words
A device according to Claim 1 or Claim 4, .wherein the first bed (34) is made of polytetrafluoroethylene.
Claim 9
Independent Claim
31 words
A device according to any one of Claims 4 to 6 in which the second bed (70) has pores of a size in the range of from 400 to 800 microns.
Claim 10
Dependent Claim
27 words
A device according to Claim 1 or any one of Claims 4 to 6 or Claim 8, in which the second bed is made of a polyester.
Claim 11
Independent Claim
34 words
A device according to any one of the preceding Claims in which the second bed (4) covers essentially all of the outer surface of the skirt (22) not overlain by the first bed (34).
Claim 12
Dependent Claim
115 words
A device according to Claim 5, wherein the path length of the first bed (34, 68) and the pore sizes of the beds (34, 40) are selected such that, upon implantation of the skirt (22) in subcutaneous tissue adjacent to the dermis, the first bed (34) permits a controlled rate of epidermal cell downgrowth and the second bed (4) permits the formation of mature collagen near the junction (36) between the first and second beds (34, 40) substantially prior to the time epidermal cell downgrowth reaches said junction, whereby said epidermal cell downgrowth is halted near the junction and a tight, biologic seal is formed between the device and adjoining tissue near the junction (36).
Claim 13
Independent Claim
27 words
A device according to any one of the preceding Claims further including a catheter tube (56) extending through the bore (28) and bonded to the neck (24).
Claim 14
Independent Claim
91 words
A device according to any one of the preceding Claims, further comprising lock means (86, 96) for releasably locking a workpiece (80, 94) within the bore (66) of the neck (64) such that the workpiece (80, 94) may be inserted and replaced without removal of said percutaneous access device (60) from an implanted position and without any substantial disturbance to skin and tissue (74) near said device, said lock means (86, 96) including means (90) for preventing twisting of said neck (64) during locking and release of said workpiece (80, 94).
Claim 15
Dependent Claim
84 words
A device according to Claim 13, wherein the workpiece comprises a tube (76) for conveying material, and said means for releasably locking the tube comprises a flexible seal (80) shaped to fit within the bore (78) of said neck (64) and to encircle a portion of said tube, and a cap (86) having a hole therethrough to accommodate the tube, said cap (86) being attachable to the neck (64) and being adapted to compress the seal (80) against the tube (76) and neck (64).
Claim 16
Dependent Claim
46 words
A device according to Claim 13, wherein the workpiece comprises a plug (94) shaped for insertion into the bore (66) of the neck (64), and the means for releasably locking the plug (94) comprises a cap (96) attachable to the neck (64) over the plug (94).
Claim 17
Dependent Claim
31 words
A device according to Claim 14, wherein the cap comprises a screw ring slidable along the tube, and the neck (64) includes a screw threaded portion (84) engagable with the cap.
Claim 18
Independent Claim
50 words
A device according to any one of Claims 13 to 16, wherein the means for preventing twisting comprises a pair of recesses (90) in the outer surface of the neck (64) to permit the holding of the neck (64) in position during locking and release of the workpiece (80, 94).
Claim 19
Dependent Claim
39 words
A device according to Claim 14, wherein a portion of the neck (64) is shaped to form a tapered cavity (78) in the bore (66) and the flexible seal (80) comprises an elastomeric material receivable in the cavity (78).
References Cited (Backward Citations)
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