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EP0164694A2
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N-Benzoyl-N'-pyrimidinyloxyphenyl urea compounds, and antitumorous compositions containing them, and process for their preparation
Assignee: Ishihara Sangyo Kaisha Ltd
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Filing: 1985-06-05
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Granted: —
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Expires: 2005-06-05
Abstract
Abstract N-benzoyl-N'-pyrimidinyloxyphenyl urea compounds having the formula: wherein X represents a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group and Z represents a hydrogen atom or a halogen atom, are useful as active ingredients of antitumorous compositions.
Inventors
- 👤 Takahiro Haga
- 👤 Nobutoshi Yamada
- 👤 Hideo Sugi
- 👤 Toru Koyanagi
- 👤 Hiroshi Okada
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 17:59
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/32; C07D239/34; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
33 words
An N-benzoyl-N'-pyrimidinyloxyphenyl urea compound having the formula: wherein X is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, and Z is a hydrogen atom or a halogen atom.
Claim 2
Dependent Claim
33 words
An N-benzoyl-N'-pyrimidinyloxyphenyl urea compound having the formula: wherein X is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, and Z is a hydrogen atom or a halogen atom.
Claim 3
Dependent Claim
26 words
The compound according to Claim 1, wherein X is a halogen atom or a nitro group, and Z is a hydrogen atom or a halogen atom.
Claim 4
Dependent Claim
18 words
The compound according to Claim 1, wherein X is a nitro group and Z is a halogen atom.
Claim 5
Dependent Claim
9 words
The compound according to Claim 1, which is N-(2-nitrobenzoyl)-N'-[4-(5-bromo-2-pyrimidinyloxy)-3-trifluoromethylphenyl]urea.
Claim 6
Dependent Claim
9 words
The compound according to Claim 1, which is N-(2-nitrobenzoyl)-N'-[4-(5-chloro-2-pyrimidinyloxy)-3-trifluoromethylphenyl]urea.
Claim 7
Dependent Claim
9 words
The compound according to Claim 1, which is N-(2-nitrobenzoyl)-N'-[4-(5-iodo-2-pyrimidinyloxy)-3-trifluoromethylphenyl]urea.
Claim 8
Dependent Claim
92 words
A process for producing an N-benzoyl-N'- pyrimidinyloxyphenyl urea compound having the formula: wherein X is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, and Z is a hydrogen atom or a halogen atom, which comprises reacting a compound of the formula: wherein X is as defined above, and R 1 is an isocyanate group or an amino group, with a compound of the formula: wherein Z is as defined above, and R 2 is an amino group or an isocyanate group which differs from R 1 .
Claim 9
Dependent Claim
92 words
A process for producing an N-benzoyl-N'- pyrimidinyloxyphenyl urea compound having the formula: wherein X is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, and Z is a hydrogen atom or a halogen atom, which comprises reacting a compound of the formula: wherein X is as defined above, and R 1 is an isocyanate group or an amino group, with a compound of the formula: wherein Z is as defined above, and R 2 is an amino group or an isocyanate group which differs from R 1 .
Claim 10
Dependent Claim
20 words
The process according to Claim 7, wherein R 1 is an isocyanate group, and R 2 is an amino group.
Claim 11
Dependent Claim
17 words
The process according to Claim 8, wherein the reaction is conducted in the presence of a solvent.
Claim 12
Dependent Claim
19 words
The process according to Claim 8, wherein the reaction is conducted at a temperature of from 0 to 120°C.
Claim 13
Dependent Claim
20 words
The process according to Claim 7, wherein R 1 is an amino group, and R 2 is an isocyanate group.
Claim 14
Dependent Claim
17 words
The process according to Claim 11, wherein the reaction is conducted in the presence of a solvent.
Claim 15
Dependent Claim
20 words
The process according to Claim 11, wherein the reaction is conducted at a temperature from 50°C to a refluxing temperature.
Claim 16
Dependent Claim
18 words
An antitumorous composition comprising an N-benzoyl-N'-pyrimidinyloxyphenyl urea compound as defined in Claim 1 and a pharmacologically acceptable adjuvant.
Claim 17
Dependent Claim
18 words
A method for therapy of cancer which comprises administering an N-benzoyl-N'-pyrimidinyloxyphenyl urea compound as defined in Claim 1.
Claim 18
Dependent Claim
27 words
An intermediate compound having the formula: wherein R 2 is an amino group or an isocyanate group, and Z is a hydrogen atom or a halogen atom.
Claim 19
Dependent Claim
27 words
An intermediate compound having the formula: wherein R 2 is an amino group or an isocyanate group, and Z is a hydrogen atom or a halogen atom.
Claim 20
Dependent Claim
23 words
The compound according to Claim 16, wherein R 2 is an amino group, and Z is a hydrogen atom or a halogen atom.
Claim 21
Dependent Claim
19 words
The compound according to Claim 16, wherein R 2 is an amino group, and Z is a halogen atom.
References Cited (Backward Citations)
No citation records indexed.
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