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Patent EP0160286A2 successfully refreshed from Google Patents.
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EP0160286A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Liposomes

Assignee: Terumo Corp
•
Filing: 1985-04-26
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Granted: —
•
Expires: 2005-04-26
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Abstract

Abstract There is disclosed a liposome having a strengthened membrane which comprises a lipid containing 0.1-20 mol% of an ascorbic acid ester. As the liquid, phospholipid particularly phosphatidyl choline and sphingomeylin are preferred. As the ascorbic acid ester, preferable is ascorbic acid mono (or di) palmitate or stearate. In the liposome, the strength of its membrane is enhanced since the ascorbic acid ester enters in between bimolecular lipid layers. Where the lipid contains an unsaturated fatty acid, oxidative degradation of said lipid is prevented, with the result that the liposome obtained is excellent in stability on standing.

Inventors

  • 👤 Juuro Aoyagi
  • 👤 Yuichi Yamamoto
  • 👤 Toshihiro Akaike
  • 👤 Yasuhiro Nozaki

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-11-09 21:32
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 16 words
A liposome having membrane which comprises a lipid containing 0.1-20 mol% of an ascorbic acid ester.
Claim 2
Dependent Claim 16 words
A liposome having membrane which comprises a lipid containing 0.1-20 mol% of an ascorbic acid ester.
Claim 3
Dependent Claim 13 words
The liposome according to Claim 1 wherein the lipid has an unsaturated bond.
Claim 4
Dependent Claim 15 words
The liposome according to Claim 2 wherein the lipid having an unsaturated bond is phospholipid.
Claim 5
Dependent Claim 13 words
The liposome according to Claim 3 wherein the phospholipid is phosphatidylcholine or sphingomyelin.
Claim 6
Dependent Claim 18 words
The liposome according to Claim 1 wherein the ascorbic acid ester is ascorbic acid higher mono- or diester.
Claim 7
Dependent Claim 26 words
The liposome according to Claim 5 wherein the ascorbic acid higher mono- or diester is ascorbic acid mono- or dipalmitate or ascorbic acid mono- or distearate.
Claim 8
Dependent Claim 13 words
The liposome according to Claim 1 wherein the liposome encapsulates a chemical compound.

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