Liposomes

Abstract

Abstract There is disclosed a liposome having a strengthened membrane which comprises a lipid containing 0.1-20 mol% of an ascorbic acid ester. As the liquid, phospholipid particularly phosphatidyl choline and sphingomeylin are preferred. As the ascorbic acid ester, preferable is ascorbic acid mono (or di) palmitate or stearate. In the liposome, the strength of its membrane is enhanced since the ascorbic acid ester enters in between bimolecular lipid layers. Where the lipid contains an unsaturated fatty acid, oxidative degradation of said lipid is prevented, with the result that the liposome obtained is excellent in stability on standing.

Inventors

• 👤 Juuro Aoyagi
• 👤 Yuichi Yamamoto
• 👤 Toshihiro Akaike
• 👤 Yasuhiro Nozaki

Bibliographic Details