Patent EP0159034A2 successfully refreshed from Google Patents.
EP0159034A2
Expired / Lapsed
EP
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Cardiovascular graft and method forming same
Assignee: Cordis Corp
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Filing: 1985-04-17
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Granted: —
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Expires: 2005-04-17
Abstract
Abstract The method for forming a biocompatible polymer graft particularly adapted for cardiovascular use comprises the steps of: choosing a suitable, non-solvent, two component, hydrophilic of hydrophobic biocompatible polymer system from which the graft may be formed; choosing a suitable water soluble inorganic salt td be compounded with the biocompatible polymer system; grinding the salt crystals and passing same through a sieve having a pre-determined mesh size. drying the salt crystals; compounding the salt crystals with the biocompatible polymer system; forming a tube from said compounded salt and polymer system by reaction injection or cast molding; and leaching the salt crystals from the formed tube with water, said leaching of said salt crystals providing a tube with a network of interconnecting cells formed in the area from which the salt crystals have been leached. Further, according to the present invention, there is also provided a graft particularly adapted for cardiovascular use, said graft comprising a tube which has been reaction injection molded, cast molded, or extruded from a non-solvent, two component hydrophilic or hydrophobic biocompatible polymer system and which has a honeycomb of interconnecting cells throughout the thickness of its wall formed by the leaching of a compounded inorganic salt therefrom.
Inventors
- 👤 Leonard Pinchuk
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-06 09:38
CPC Classifications
C; C08; C08J; C08J9/00; C08J9/26; A; A61; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L; A61L27/00; A61L27/14; A61L27/16; A61L27/18; A61L27/50; A61L27/507; A61L27/56; C08J9/24; C08L; C08L27/00; C08L27/02; C08L27/12; C08L27/18; C08L75/00; C08L75/04; C08L83/00; C08L83/04; B; B29; B29C; B29C45/00; B29C45/17; B29C45/1703; B29C45/1704; B29C2045/1719; B29K; B29K2995/00; B29K2995/0037; B29K2995/0056; B29L; B29L2023/00; B29L2023/005; B29L2023/007; B29L2031/00; B29L2031/753; B29L2031/7532; B29L2031/7534
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
136 words
A method for forming a biocompatible polymer graft particularly adapted for cardiovascular use, said method comprising the steps of : choosing a suitable, non-solvent, two component, hydrophilic or hydrophobic biocompatible polymer system from which the graft may be formed; choosing a suitable water soluble inorganic salt to be compounded with the biocompatible plymer system; grinding the salt crystals and passing same through a sieve having a predetermined mesh size; drying the salt crystals; compounding the salt crystals with the biocompatible polymer system; forming a tube from said compounded salt and polymer system by reaction injection or cast molding; and leaching the salt crystals from the formed tube with water, said leaching of said salt crystals providing a tube with a network of interconnecting cells formed in the area from which the salt crystals have been leached.
Claim 2
Independent Claim
136 words
A method for forming a biocompatible polymer graft particularly adapted for cardiovascular use, said method comprising the steps of : choosing a suitable, non-solvent, two component, hydrophilic or hydrophobic biocompatible polymer system from which the graft may be formed; choosing a suitable water soluble inorganic salt to be compounded with the biocompatible plymer system; grinding the salt crystals and passing same through a sieve having a predetermined mesh size; drying the salt crystals; compounding the salt crystals with the biocompatible polymer system; forming a tube from said compounded salt and polymer system by reaction injection or cast molding; and leaching the salt crystals from the formed tube with water, said leaching of said salt crystals providing a tube with a network of interconnecting cells formed in the area from which the salt crystals have been leached.
Claim 3
Dependent Claim
17 words
The method of claim 1 wherein the biocompatible polymer system comprises a polymer resin and curing agent.
Claim 4
Dependent Claim
19 words
The method of claim 2 wherein said polymer is chosen from the group comprising polyurethane, silicone rubber and tetrafluoroethylene.
Claim 5
Dependent Claim
26 words
The method of claim 2 wherein said curing agent is chosen from the group comprising platinum, temperat- . ed steel heat, cross-linkers, gamma radiation and ureaformaldehyde.
Claim 6
Dependent Claim
17 words
The method of claim 1 wherein said inorganic salt is chosen to provide cells of predetermined size.
Claim 7
Dependent Claim
13 words
The method of claim 6 wherein said inorganic salt is preferably sodium chloride.
Claim 8
Dependent Claim
21 words
The method of claim 1 wherein said salt crystals are dried in an oven at a temperature between 100 and 175°C.
Claim 9
Dependent Claim
11 words
The method of claim 7 wherein said temperature is approximately 135°C.
Claim 10
Dependent Claim
16 words
The method of claim 1 wherein said crystals are dried for a minimum of 24 hours.
Claim 11
Dependent Claim
16 words
The method of claim 1 wherein said sieve is chosen to have a predetermined mesh size.
Claim 12
Dependent Claim
23 words
The methhod of claim 1 wherein the ratio of water soluble inorganic salt to said biocompatible polymer system ranges from 25-75% by weight.
Claim 13
Dependent Claim
22 words
The method of claim 11 wherein said range is determined by the required flexibility and/or porosity of the graft to be fabricated.
Claim 14
Dependent Claim
16 words
The method of claim 1 wherein said cells are of a uniform diameter within the graft.
Claim 15
Dependent Claim
16 words
The method of claim 1 wherein said cells may vary in diameter from graft to graft.
Claim 16
Dependent Claim
31 words
The method of claim 1 wherein the diameter of the cells within the graft is dictated by the location at which the graft is to be used within the cardiovascular system.
Claim 17
Dependent Claim
36 words
The method of claim 1 wherein the wall thickness of the graft may vary from 5 cm to 4 cm depending on the location' at which the graft is to be used in the cardiovascular system.
Claim 18
Dependent Claim
21 words
The method of claim 13 wherein the diameter of the cells in the graft may range from 10 to 200 microns.
Claim 19
Dependent Claim
9 words
A graft made by the process of claim 1.
Claim 20
Dependent Claim
58 words
A graft particularly adapted for cardiovascular use, said graft comprising a tube which has been reaction injection molded, cast molded, or extruded from a non-solvent, two component hydrophilic or hydrophobic biocompatible polymer system and which has a honeycomb of interconnecting cells throu- out the thickness of its wall formed by the leaching of a compounded inorganic salt therefrom.
Claim 21
Dependent Claim
58 words
A graft particularly adapted for cardiovascular use, said graft comprising a tube which has been reaction injection molded, cast molded, or extruded from a non-solvent, two component hydrophilic or hydrophobic biocompatible polymer system and which has a honeycomb of interconnecting cells throu- out the thickness of its wall formed by the leaching of a compounded inorganic salt therefrom.
Claim 22
Dependent Claim
16 words
The graft of claim 19 wherein the biocompatible polymer system is apolymer resin and curing agent.
Claim 23
Dependent Claim
20 words
The graft of claim 20 wherein said polymer resin is chosen from the group comprising polyurethane, silicone and tetrafluoroethylene (Teflon).
Claim 24
Dependent Claim
25 words
The graft of claim 20 wherein said curing agent is chosen from the group comprising platinum, temperated steel heat, cross linkers, gamma radiation and ureaformaldehyde.
Claim 25
Dependent Claim
17 words
The graft of claim 19 wherein said inorganic salt is chosen to provide cells of predetermined size.
Claim 26
Dependent Claim
13 words
The graft of claim 23 wherein said inorganic salt is preferably sodium chloride.
Claim 27
Dependent Claim
21 words
The graft of claim 19 wherein said salt crystals are dried in an oven at a temperature between 100 and 175°C.
Claim 28
Dependent Claim
11 words
The graft of claim 25 wherein said temperature is approximately 135°C.
Claim 29
Dependent Claim
16 words
The graft of claim 19 wherein said crystals are dried for a minimum of 24 hours.
Claim 30
Dependent Claim
16 words
The graft of claim 19 wherein said sieve is chosen to have a predetermined mesh size.
Claim 31
Dependent Claim
23 words
The graft of claim 19 wherein the ratio of water soluble inorqanic salt to said biocompatible polymer system ranges from 25-75% by weight.
Claim 32
Dependent Claim
21 words
The graft of claim 29 wherein said range is determined by the required flexibility and/or porosity of thegraft to be fabricated.
Claim 33
Dependent Claim
16 words
The graft of claim 19 wherein said cells are of a uniform diameter within the graft.
Claim 34
Dependent Claim
16 words
The graft of claim 19 wherein said cells may vary in diameter from graft to graft.
Claim 35
Dependent Claim
31 words
The graft of claim 19 wherein the diameter of the cells within the graft is dictated by the location at which the graft is to be used within the cardiovascular system.
Claim 36
Dependent Claim
36 words
The graft of claim 19 wherein the wall thickness of the graft may vary from 5 cm to 4 cm depending on the location at which the graft is to be used within the cardiovascular system.
Claim 37
Dependent Claim
21 words
The graft of claim 31 wherein the diameter of the cells in the graft may range from 10 to 200 microns.
References Cited (Backward Citations)
No citation records indexed.
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