A glutamate receptor inhibitor

Claim 1

A glutamate receptor inhibitor, obtainable from Joro spider venom glands, having the following properties: (1) Molecular weight is within the range of 500 ± 200; (2) It is substantially insoluble in ethyl acetate and soluble in water; (3) The activity remains unchanged when heated to 80°C for 20 minutes in water; (4) The activity remains unchanged when heated to 80°C for 20 minutes in 0.4 M perchloric acid; (5) It shows in electrophoresis neutral electric charge with use of 0.01 M phosphate buffer (pH 7) and positive electric charge using 0.2 M formate buffer (pH 2.25); (6) It develops color with ninhydrin and fluoresces with fluorescamine; (7) It yields Rf values 0.20 on "Silica gel 60 thin-layer plate (E. Merck AG)" developed with phenol-water mixed solvent 3:1 (V/V), and 0.54 and 0.65 on "Cellulose thin-layer plate (E. Merck AG)" developed with phenol-water mixed solvent 3:1 (V/V) and n-propanol-water mixed solvent 7:3 (V/V) respectively; ( 8 ) It shows maximum absorption at 270nm, minimum absorption at 245 nm in water (pH 6.1).