Patent EP0154432A2 successfully refreshed from Google Patents.
EP0154432A2
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EP
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Modified urokinase composition
Assignee: NIHON CHEMICAL RESEARCH also known as JAPAN CHEMICAL RESEARCH Co Ltd KK
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Filing: 1985-02-15
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Granted: —
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Expires: 2005-02-15
Abstract
Abstract A novel urokinase of the formula: R-CO-NH urokinase wherein R is the residue of a water-soluble homo- or copolymer with a molecular weirht of 2,000 to 10,000, can be produced by reacting a carbonylimidazole derivative of the formula: with urokinase in a buffer solution at pH 6 to 11. The product is resistible to urokinase inhibitors, highly stable in blood and serves as a thrombolytic agent having durable effect.
Inventors
- 👤 Kiichi Sawai
- 👤 Masayasu Kurono
- 👤 Juichi Awaya
- 👤 Tadahiko Iwata
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-06 12:42
CPC Classifications
C; C12; C12Y; C12Y304/00; C12Y304/21; C12Y304/21073; C12N; C12N11/00; C12N11/02; C12N11/08; C12N11/089; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; C12N9/00; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6424; C12N9/6456; C12N9/6462; A61K38/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
26 words
A modified urokinase of the formula wherein R is the residue of a water-soluble homo- or co-polymer compound with a molecular weight of 2,000 to 10,000.
Claim 2
Dependent Claim
26 words
A modified urokinase of the formula wherein R is the residue of a water-soluble homo- or co-polymer compound with a molecular weight of 2,000 to 10,000.
Claim 3
Dependent Claim
19 words
A modified urokinase as claimed in Claim 1 wherein the moiety R is the residue of a monomethoxy-polyethylene glycol.
Claim 4
Dependent Claim
19 words
A modified urokinase as claimed in Claim 2, wherein the moiety R has an average molecular weight of 5,000.
Claim 5
Dependent Claim
20 words
A modified urokinase as claimed in Claim 1 wherein the moiety R is the residue of a monomethoxy-polyethylene glycol-polypropylene glycol.
Claim 6
Dependent Claim
19 words
A modified urokinase as claimed in Claim 4, wherein the moiety R has an average molecular weight of 5,000.
Claim 7
Dependent Claim
33 words
A modified urokinase as claimed in any one of the preceding Claims having a molecular weight in the range of 100,000 to 150,000 and modified to a residual activity of 20 to 40%.
Claim 8
Dependent Claim
19 words
A modified urokinase as claimed in any one of the preceding Claims for use in the treatment of thrombosis.
Claim 9
Independent Claim
62 words
A method of producing a modified urokinase as claimed in any one of the preceding Claims which comprises reacting a homo- or co-polymer carbonylimidazole derivative of the formula wherein R is the residue of a water-soluble homo- or co-polymer compound with a molecular weight of 2,000 to 10,000, with urokinase in the presence of a buffer solution at pH 6 to 11.
Claim 10
Dependent Claim
29 words
A thrombolytic composition containing a modified urokinase as claimed in any one of Claims 1 to 6 in admixture, or otherwise associated, with a pharmaceutically acceptable diluent or carrier.
Claim 11
Dependent Claim
21 words
The use of a modified urokinase as claimed in any one of Claims 1 to 6 for preparing a thrombolytic composition.
References Cited (Backward Citations)
No citation records indexed.
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