Patent EP0141648A2 successfully refreshed from Google Patents.
EP0141648A2
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EP
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Reflective particle-containing analytical device
Assignee: Bayer Corp
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Filing: 1984-10-31
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Granted: —
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Expires: 2004-10-31
Abstract
Abstract @ A device for determining an analyte in a liquid sample consists essentially of a single integral matrix, comprising (a) a plurality of solid, reflective, inorganic particles (22); (b) at least one substance (24) which effects a detectable response to the analyte and is associated with the surface of said particles; and (c) a binder (26) which is permeable to the analyte or a reaction product thereof. Preferably, the particles are non-spherical and have a refractive index greater than about 1.6. The analyte-responsive substance can include a first component which is responsive to the analyte to form a reaction product, and a second component separated from the first component by the binder and responsive to the reaction product to effect a detectable change. It is the second component which is usually associated with the surface of the particles. The device is effective in the absence of other elements or structures to provide a quantitative detectable response to the presence of the analyte under assay.
Inventors
- 👤 Anand Kumar
- 👤 Koon-Wah Leong
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 01:53
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; G01N33/521
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
69 words
A device for determining an analyte in a liquid sample, which device (10) consists essentially of a single, integral matrix comprising: (a) a plurality of solid, reflective, inorganic particles (22); (b) at least one substance (24) which effects a detectable response to said analyte and is associated with the surface of said particles; (c) a binder (26) which is selectively permeable to said analyte or a reaction product thereof.
Claim 2
Independent Claim
69 words
A device for determining an analyte in a liquid sample, which device (10) consists essentially of a single, integral matrix comprising: (a) a plurality of solid, reflective, inorganic particles (22); (b) at least one substance (24) which effects a detectable response to said analyte and is associated with the surface of said particles; (c) a binder (26) which is selectively permeable to said analyte or a reaction product thereof.
Claim 3
Dependent Claim
21 words
A device according to claim 1, wherein the particles have a diameter of from about one-tenth micron to about 200 microns.
Claim 4
Dependent Claim
50 words
A device according to claim 1 or 2, wherein the particles are basic lead hydroxide, basic lead carbonate, titanium dioxide, zinc oxide, magnesium oxide, lead oxide, barium sulfate, calcium sulfate, strontium sulfate, silica, calcite, silicates and aluminosilicates, zinc sulfide, diatomaceous earth, clay or any mixture of two of more thereof.
Claim 5
Dependent Claim
24 words
A device according to claim 1,2 or 3, wherein the binder comprises at least one macromolecular substance, preferably a protein, polymer, gum or wax.
Claim 6
Dependent Claim
40 words
A device according to claim 4, wherein the binder is a polymer selected from homopolymers and copolymers of cellulose acetate, polyvinyl chloride, nylon, starch, polycarbonate, polyvinyl alcohol, polyvinyl acetate, polyvinyl pyrrolidone, polyurethane, cellulose, cellulose nitrate, polysulfone and cellulose acetate butyrate.
Claim 7
Independent Claim
27 words
A device according to any of claims 1 to 5, for determining hemoglobin wherein the at least one analyte-responsive substance is a cytolytic agent, preferably a surfactant.
Claim 8
Independent Claim
36 words
A device according to any of claims 1 to 5, for determining bilirubin, wherein the at least one analyte-responsive substance includes a diazo compound, preferably sulfanilic acid, and a displacing agent, preferably diphylline, caffeine or dimethylsulfoxide.
Claim 9
Independent Claim
28 words
A device according to any of claims 1 to 5, for determining glucose, wherein the analyte-responsive substance includes glucose oxidase, a peroxidatively active substance and a redox indicator.
Claim 10
Independent Claim
20 words
A device according to any of claims 1 to 5, for determining albumin, wherein the analyte-responsive substance includes bromcresol green.
Claim 11
Independent Claim
61 words
A device according to any of claims 1 to 5, wherein the analyte-responsive substance comprises a first component which is responsive to the analyte to form a reaction product, and a second component, preferably associated with the surface of the particles, which is separated from the first component by the binder and which effects a detectable response to the reaction product.
Claim 12
Dependent Claim
43 words
A device according to claim 10 wherein the first component is reactive with the analyte to produce hydrogen peroxide and the second component includes a peroxidatively active substance and a redox indicator and is reactive with hydrogen peroxide to produce a detectable response.
Claim 13
Dependent Claim
20 words
A device according to claim 11, for determining cholesterol, wherein the first component includes cholesterol oxidase and cholesterol ester hydrolase.
Claim 14
Dependent Claim
16 words
A device according to claim 11, for determining uric acid, wherein the first component includes uricase.
Claim 15
Dependent Claim
16 words
A device according to claim 11, for determining glucose, wherein the first component includes glucose oxidase.
References Cited (Backward Citations)
No citation records indexed.
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