Patent EP0140640A2 successfully refreshed from Google Patents.
EP0140640A2
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EP
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Blood substitute
Assignee: Fisons Ltd
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Filing: 1984-10-16
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Granted: —
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Expires: 2004-10-16
Abstract
Abstract There is described a water soluble compound having a molecular weight of from about 70,000 to about 2,000,000, and having the formula 1,where PS represents a physiologically acceptable polysaccharide of molecular weight from about 2,000 to about 2,000,000,X represents a covalently bonded chemical bridging group,HB represents a haemoglobin residue, andZ represents an oxygen affinity reducing ligand, containing 2 or more phosphate groups.There is also described haemoglobin linked to an oxygen affinity reducing ligand derived from inositol phosphate, and polymers of such linked haemoglobin.Processes for making the compounds, and their formulation and use as oxygen transporting agents, are also described.
Inventors
- 👤 Jeffrey Tze-Fei Wong
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 22:25
CPC Classifications
C; C08; C08H; C08H1/00; A; A61; A61P; A61P7/00; A61P7/08; C07; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/08; C07F9/09; C07F9/091; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0021
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
63 words
A water soluble compound having a molecular weight of from about 70,000 to about 2,000,000, and having the formula I, where PS represents a physiologically acceptable polysaccharide of molecular weight from about 2,000 to about 2,000,000, X represents a covalently bonded chemical bridging group, HB represents a haemoglobin residue, and Z represents an oxygen affinity reducing ligand, containing 2 or more phosphate groups.
Claim 2
Dependent Claim
63 words
A water soluble compound having a molecular weight of from about 70,000 to about 2,000,000, and having the formula I, where PS represents a physiologically acceptable polysaccharide of molecular weight from about 2,000 to about 2,000,000, X represents a covalently bonded chemical bridging group, HB represents a haemoglobin residue, and Z represents an oxygen affinity reducing ligand, containing 2 or more phosphate groups.
Claim 3
Dependent Claim
25 words
A compound according to Claim 1, wherein Z is a polyol, two or more of the hydroxy groups of which are esterified with phosphoric acid.
Claim 4
Dependent Claim
17 words
A compound according to Claim 1 or 2, wherein Z contains from 2 to 6 phosphate groups.
Claim 5
Dependent Claim
38 words
A compound according to any one of the preceding claims wherein Z is derived from a compound of formula IV, in which at least 2 of the groups Rx are phosphate groups an the remainder are -OH groups.
Claim 6
Dependent Claim
25 words
A compound according to any one of the preceding claims, wherein the polysaccharide is a dextran of average molecular weight of from 10,000 to 100,000.
Claim 7
Dependent Claim
23 words
A compound according to any one of the preceding claims, wherein the phosphate to haemoglobin ratio is in the range 2 to 16:1.
Claim 8
Dependent Claim
16 words
A modified haemoglobin of formula (HB)-Za in which Za is a group derived from inositol phosphate.
Claim 9
Dependent Claim
16 words
A modified haemoglobin of formula (HB)-Za in which Za is a group derived from inositol phosphate.
Claim 10
Dependent Claim
9 words
A compound according to Claim 7 in polymerised form.
Claim 11
Dependent Claim
90 words
A process for the production of a compound of formula I as defined in Claim 1, which comprises (a) linking a compound for formula II, in which PS, X and HB are as defined above, with a compound capable of providing a Z ligand, (b) linking a compound of formula III, in which HB and Z are as defined above, with a polysaccharide PS, or (c) producing a reduced form of a compound of formula I, by reduction of a corresponding compound of formula I containing a reducible double bond.
Claim 12
Dependent Claim
25 words
A pharmaceutical formulation comprising a compound according to any one of Claims 1 to 8 in admixture with a pharmaceutically acceptable excipient, diluent or carrier.
Claim 13
Dependent Claim
143 words
A process for the production of a water soluble compound having a molecular weight of from about 70,000 to about 2,000,000, and having the formula I, where PS represents a physiologically acceptable polysaccharide of molecular weight from about 2,000 to about 2,000,000, X represents a covalently bonded chemical bridging group, HB represents a haemoglobin residue, and Z represents an oxygen affinity reducing ligand, containing 2 or more phosphate groups, which comprises (a) linking a compound for formula II, in which PS, X and HB are as defined above, with a compound capable of providing a Z ligand, (b) linking a compound of formula III, in which HB and Z are as defined above, with a polysaccharide PS, or (c) producing a reduced form of a compound of formula I, by reduction of a corresponding compound of formula I containing a reducible double bond.
Claim 14
Dependent Claim
143 words
A process for the production of a water soluble compound having a molecular weight of from about 70,000 to about 2,000,000, and having the formula I, where PS represents a physiologically acceptable polysaccharide of molecular weight from about 2,000 to about 2,000,000, X represents a covalently bonded chemical bridging group, HB represents a haemoglobin residue, and Z represents an oxygen affinity reducing ligand, containing 2 or more phosphate groups, which comprises (a) linking a compound for formula II, in which PS, X and HB are as defined above, with a compound capable of providing a Z ligand, (b) linking a compound of formula III, in which HB and Z are as defined above, with a polysaccharide PS, or (c) producing a reduced form of a compound of formula I, by reduction of a corresponding compound of formula I containing a reducible double bond.
Claim 15
Dependent Claim
25 words
A process according to Claim 1, wherein Z is a polyol, two or more of the hydroxy groups of which are esterified with phosphoric acid.
Claim 16
Dependent Claim
17 words
A process according to Claim 1 or 2, wherein Z contains from 2 to 6 phosphate groups.
Claim 17
Dependent Claim
38 words
A process according to any one of the preceding claims wherein Z is derived from a compound of formula IV, in which at least 2 of the groups Rx are phosphate groups an the remainder are -OH groups.
Claim 18
Dependent Claim
25 words
A process according to any one of the preceding claims, wherein the polysaccharide is a dextran of average molecular weight of from 10,000 to 100,000.
Claim 19
Dependent Claim
23 words
A process according to any one of the preceding claims, wherein the phosphate to haemoglobin ratio is in the range 2 to 16:1.
References Cited (Backward Citations)
No citation records indexed.
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