EP0128670A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
4-Demethoxy-3'-deamino-3'(4-morpholinyl) derivatives of anthracycline anticancer antibiotics
Assignee: Pharmacia and Upjohn Co
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Filing: 1984-05-11
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Granted: —
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Expires: 2004-05-11
Abstract
Abstract 3'-deamino-3'-(4-morpholinyl) and 3'-deamino-3'-(3-cyano-4-morpholinyl) derivatives of 4-demethoxydaunorubicin and 4-demethoxydoxorubicin together with their 13-dihydro analogues and their pharmaceutically acceptable acid addition salts are disclosed. These compounds have utility as antitumor agents.
Inventors
- 👤 John Paul Carter
- 👤 Richard L. Wolgemuth
- 👤 Richard Alfred Carrano
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 18:04
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/252; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
40 words
A compound of the formula (I) where R is COCH 3 , COCH2 0 H , CH(OH)CH 3 , or CH(OH)CH 20H and R ' is a hydrogen atom or a cyano group and its pharmaceutically acceptable acid addition salts.
Claim 2
Dependent Claim
40 words
A compound of the formula (I) where R is COCH 3 , COCH2 0 H , CH(OH)CH 3 , or CH(OH)CH 20H and R ' is a hydrogen atom or a cyano group and its pharmaceutically acceptable acid addition salts.
Claim 3
Dependent Claim
13 words
The compound 3'-deamino-4-demethoxy-3'-(4-morpholinyl)-daunorubicin of claim 1 and its pharmaceutically acceptable acid addition salts.
Claim 4
Dependent Claim
13 words
The compound 3'-deamino-4-demethoxy-3'-(3-cyano-4-morpholinyl)-daunorubicin of claim 1 and its pharmaceutically acceptable acid addition salts.
Claim 5
Dependent Claim
13 words
The compound 3'-deamino-4-demethoxy-3'-(4-morpholinyl)-13-dihydrodaunorubicin of claim 1 and its pharmaceutically acceptable acid addition salts.
Claim 6
Dependent Claim
13 words
The compound 3'-deamino-4-demethoxy-3'-(3-cyano-4-morpholinyl)-13-dihydrodaunorubicin of claim 1 and its pharmaceutically acceptable acid addition salts.
Claim 7
Dependent Claim
13 words
The compound 3'-deamino-4-demethoxy-3'-(4-morpholinyl)-doxorubicin of claim 1 and its pharmaceutically acceptable acid addition salts.
Claim 8
Dependent Claim
13 words
The compound 3'-deamino-4-demethoxy-3'-(3-cyano-4-morpholinyl)-doxorubicin of claim 1 and its pharmaceutically acceptable acid addition salts.
Claim 9
Dependent Claim
10 words
The compound 3'-deamino-4-demethoxy-3'-(4-morpholinyl)-13-dihydrodoxorubicin and its pharmaceutically acceptable acid addition salts.
Claim 10
Dependent Claim
10 words
The compound 3'-deamino-4-demethoxy-3'-(4-morpholinyl)-13-dihydrodoxorubicin and its pharmaceutically acceptable acid addition salts.
Claim 11
Dependent Claim
53 words
A pharmaceutical preparation comprising, in a non-toxic pharmaceutically acceptable carrier, a therapeutically effective amount of a compound of the formula (I) where R is COCH3, COCH 2 0H, CH(OH)CH 3 , or CH(OH)CH 2 OH and R ' is a hydrogen atom or a cyano group or a pharmaceutically acceptable acid salt thereof.
Claim 12
Dependent Claim
53 words
A pharmaceutical preparation comprising, in a non-toxic pharmaceutically acceptable carrier, a therapeutically effective amount of a compound of the formula (I) where R is COCH3, COCH 2 0H, CH(OH)CH 3 , or CH(OH)CH 2 OH and R ' is a hydrogen atom or a cyano group or a pharmaceutically acceptable acid salt thereof.
Claim 13
Dependent Claim
19 words
The pharmaceutical preparation of claim 10 wherein said compound is 3'-deamino-4-demethoxy-3'-(4-morpholinyl)-daunorubicin or a pharmaceutically acceptable acid addition salt thereof.
Claim 14
Dependent Claim
19 words
The pharmaceutical preparation of claim 10 wherein said compound is 3'-deamino-4-demethoxy-3'-(3-cyano-4-morpholinyl)-daunorubicin or a pharmaceutically acceptable acid addition salt thereof.
Claim 15
Dependent Claim
19 words
The pharmaceutical preparation of claim 10 wherein said compound is 3'-deamino-4-demethoxy-3'-(4-morpholinyl)-13-dihydrodaunorubicin or a pharmaceutically acceptable acid addition salt thereof.
Claim 16
Dependent Claim
21 words
The pharmaceutical preparation of claim 10 wherein said compound is 3'-deamino-4-demethoxy-3 1- (3-cyano-4-morpholinyl)-13-dihydrodaunorubicin or a pharmaceutically acceptable acid addition salt thereof.
Claim 17
Dependent Claim
19 words
The pharmaceutical preparation of claim 10 wherein said compound is 3'-deamino-4-demethoxy-3'-(4-morpholinyl)-doxorubicin or a pharmaceutically acceptable acid addition salt thereof.
Claim 18
Dependent Claim
19 words
The pharmaceutical preparation of claim 10 wherein said compound is 3'-deamino-4-demethoxy-3'-(3-cyano-4-morpholinyl)-doxorubicin or a pharmaceutically acceptable acid addition salt thereof.
Claim 19
Dependent Claim
19 words
The pharmaceutical preparation of claim 10 wherein said compound is 3'-deamino-4-demethoxy-3'-(4-morpholinyl)-13-dihydrodoxorubicin or a pharmaceutically acceptable acid addition salt thereof.
Claim 20
Dependent Claim
19 words
The pharmaceutical preparation of claim 10 wherein said compound is 3'-deamino-4-demethoxy-3'-(3-cyano-4-morpholinyl)-13-dihydrodoxorubicin or a pharmaceutically acceptable acid addition salt thereof.
Claim 21
Dependent Claim
27 words
A process of preparing the compound or pharmaceutical preparation, as the case may be, according to any one of the preceding claims and substantially as hereinbefore described.
References Cited (Backward Citations)
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