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EP0124363A2
Expired / Lapsed
EP
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Photochemical decontamination treatment of whole blood or blood components
Assignee: Bayer Corp
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Filing: 1984-04-27
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Granted: —
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Expires: 2004-04-27
Abstract
Abstract Biological compositions are freed of functional polynucleotides by treatment of the biological composition with psoralen derivatives under irradiation conditions in which the proteins retain their original physiological activities and any polynucleotide present is rendered inactive.
Inventors
- 👤 Gary P. Wiesehahn
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-29 22:13
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K31/00; A61K31/13; A61K31/14; A61K35/16; A61K39/00; A61L; A61L2/00; A61L2/02; A61L2/08; A61L2/10; A61M; A61M1/00; A61M1/36; A61M1/3681; A61M1/3683; A61K38/00; A61L2103/00; A61L2103/05; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
78 words
A method for decontaminating biological protein containing compositions to inactivate any polynucleotides present capable of replication in a mammalian host, said method comprising: irradiating an aqueous biological protein containing composition to which has been added at least one furocoumarin in an amount sufficient to inactive the said polynucleotides present in the medium at a wavelength and for a sufficient time to inactivate said polynucleotides present in said medium while substantially retaining the physiological activity of said biological composition.
Claim 2
Independent Claim
78 words
A method for decontaminating biological protein containing compositions to inactivate any polynucleotides present capable of replication in a mammalian host, said method comprising: irradiating an aqueous biological protein containing composition to which has been added at least one furocoumarin in an amount sufficient to inactive the said polynucleotides present in the medium at a wavelength and for a sufficient time to inactivate said polynucleotides present in said medium while substantially retaining the physiological activity of said biological composition.
Claim 3
Dependent Claim
13 words
A method according to Claim 1, wherein at least two furocoumarins are present.
Claim 4
Dependent Claim
19 words
A method according to Claim 1, wherein said aqueous medium is blood or a blood component containing aqueous medium.
Claim 5
Dependent Claim
14 words
A method according to Claim 3, wherein said blood component is a clotting factor.
Claim 6
Independent Claim
25 words
A method according to any of Claims 1 or 2 wherein any unreacted furocoumarin(s) or photobreakdown products thereof are selectively removed by ultrafiltration or dialysis.
Claim 7
Independent Claim
28 words
A method according to Claims 1 and 2 wherein furocoumarins or biological components which have reacted with the furocoumarin(s) are selectively removed by antibodies to those modified components.
Claim 8
Independent Claim
93 words
A method for decontaminating blood or an aqueous medium containing a blood component by inactivating polynucleotides capable of replication in a mammalian host, which comprises: circulating said medium containing at least one furocoumarin in a total furocoumarin concentration of at least 1µg/ml and not more than about 300pg/ml through a light beam of wavelengths in the range of about 300nm to 400nm at an intensity of about O.lmW/cm 2 to 5W/cm 2 and at a depth of at least about 0.025 millimeters for a total irradiation time of from about 5min. to 12hrs.
Claim 9
Independent Claim
93 words
A method for decontaminating blood or an aqueous medium containing a blood component by inactivating polynucleotides capable of replication in a mammalian host, which comprises: circulating said medium containing at least one furocoumarin in a total furocoumarin concentration of at least 1µg/ml and not more than about 300pg/ml through a light beam of wavelengths in the range of about 300nm to 400nm at an intensity of about O.lmW/cm 2 to 5W/cm 2 and at a depth of at least about 0.025 millimeters for a total irradiation time of from about 5min. to 12hrs.
Claim 10
Dependent Claim
20 words
A method according to Claim 7, wherein two furocoumarins are in said medium, said two furocoumarins being 4'-hydroxymethyl-4,5',8-trimethylpsoralen and 4'-aminomethyl-4,5',8-trimethylpsoralen.
Claim 11
Dependent Claim
14 words
A method according to Claim 8 wherein said decontaminating is of a blood component.
Claim 12
Dependent Claim
14 words
A method according to Claim 9, wherein said blood component is a clotting factor.
Claim 13
Independent Claim
25 words
A method according to any of Claims 1 or 2 wherein Hepatitis A, Hepatitis B and Non-A Non-B Hepatitis viruses are inactivated in biological compositions.
Claim 14
Independent Claim
25 words
A method according to any of Claims 1 or 2 wherein the agent which causes Acquired Immune Deficiency Syndrome (AIDS) is inactivated in biological compositions.
References Cited (Backward Citations)
No citation records indexed.
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