EP0119342A1
Expired / Lapsed
EP
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Dimeric oligopeptides as haptenic epitopic sites for hepatitis
Assignee: University of California Berkeley
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Filing: 1983-07-08
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Granted: —
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Expires: 2003-07-08
Abstract
Abstract Methods and compositions concerned with the a determinant of hepatitis B antigen, providing immunogens and antibodies. The immunogens can serve as vaccines. They include a dimeric oligopeptide having not more than 15 amino-acids in each leg mimicking the amino acids 139-147 of hepatitis B antigen, which is conjugated to an immunogen such as a tetanus or diphtheria toxoid.
Inventors
- 👤 Girish N. Vyas
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-26 19:30
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; A; A61; A61K; A61K39/00; A61K39/385; A61K2039/60; A61K2039/6031; A61K2039/6037; C12; C12N; C12N2730/00; C12N2730/00011; C12N2730/10011; C12N2730/10111; C12N2730/10122; Y; Y10; Y10S; Y10S530/00; Y10S530/806; Y10S930/00; Y10S930/01; Y10S930/22; Y10S930/223
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
69 words
A vaccine composition for immunizing a mammal against hepatitis comprising a dimeric oligopeptide having not more than 15 amino acids in each leg, wherein each of the members of each leg of said dimer immunologically mimic the amino acid segment of amino acids 139-147 of hepatitis B surface antigen, said dimer conjugated to an immunogen for a predetermined host to provide an immunogenic conjugate in a physiologically acceptable medium.
Claim 2
Dependent Claim
69 words
A vaccine composition for immunizing a mammal against hepatitis comprising a dimeric oligopeptide having not more than 15 amino acids in each leg, wherein each of the members of each leg of said dimer immunologically mimic the amino acid segment of amino acids 139-147 of hepatitis B surface antigen, said dimer conjugated to an immunogen for a predetermined host to provide an immunogenic conjugate in a physiologically acceptable medium.
Claim 3
Dependent Claim
56 words
A vaccine according to Claim 1, wherein said dimeric oligopeptide consists of the amino acid segment of amino acids 139 to 146 of hepatitis B surface antigen and α-aminobutyric acid as the C-terminal acid in place of -the naturally occurring amino acid at position 147, wherein the dimer is linked by the disulfide linkage of cystine.
Claim 4
Dependent Claim
15 words
A vaccine according to Claim 1 or Claim 2, wherein said immunogen is tetanus toxoid.
Claim 5
Dependent Claim
15 words
A vaccine according to Claim 1 or Claim 2, wherein said immunogen is diphtheria toxoid.
Claim 6
Dependent Claim
26 words
A vaccine according to any one of the preceding Claims, wherein said dimer is conjugated to said immunogen by activation with carbodiimide in an aqueous medium.
Claim 7
Dependent Claim
21 words
A vaccine comprising a conjugate of an haptenic determinant site of a pathogen and the antigen tetanus toxoid or diphtheria toxoid.
Claim 8
Dependent Claim
21 words
A vaccine comprising a conjugate of an haptenic determinant site of a pathogen and the antigen tetanus toxoid or diphtheria toxoid.
Claim 9
Dependent Claim
18 words
A vaccine according to Claim 6, wherein said pathogen is a virus and said antigen is tetanus toxoid.
Claim 10
Dependent Claim
34 words
A compound of the formula: wherein: B is hydroxyl or the residue of an hydroxylic compound which provides an ester which forms amide bonds with polypeptides in aqueous media; and Aba is α-aminobutyric acid.
Claim 11
Dependent Claim
34 words
A compound of the formula: wherein: B is hydroxyl or the residue of an hydroxylic compound which provides an ester which forms amide bonds with polypeptides in aqueous media; and Aba is α-aminobutyric acid.
Claim 12
Dependent Claim
19 words
A composition comprising a compound according to Claim 8 joined to an antigen by means of water soluble carbodiimide.
Claim 13
Dependent Claim
12 words
A composition according to Claim 9, wherein said antigen is tetanus toxoid.
Claim 14
Dependent Claim
12 words
A composition according to claim 9, wherein said antigen is diphtheria toxoid.
Claim 15
Dependent Claim
36 words
J2. A method for immunizing a mammalian host against hepatitis, which comprises administering to said host under conditions to produce an immune response a vaccine, compound or composition according to any one of the preceding Claims.
References Cited (Backward Citations)
EP0044710A1
Cited
EP0056249A2
Cited
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