Patent EP0117657A1 successfully refreshed from Google Patents.
EP0117657A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Rabies immunogenic polypeptides and vaccine using them, DNA sequences, expression vectors, recombinant cells, and cultures therefor, and processes for their production
Assignee: Genentech Inc
•
Filing: 1984-02-01
•
Granted: —
•
Expires: 2004-02-01
Abstract
Abstract Polypeptides which correspond to or are analogs of the glycoprotein associated with rabies virus, are synthesized by recombinant DNA technology, thereby poroviding noninfec- tious agents for use as rabies vaccine.
Inventors
- 👤 David Vannorman Goeddel
- 👤 Elizabeth Mcleod Yelverton
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 04:33
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; C07K16/00; C07K16/08; C07K16/10; A; A61; A61K; A61K39/00; C12; C12N; C12N2760/00; C12N2760/00011; C12N2760/20011; C12N2760/20111; C12N2760/20122
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
53 words
A polypeptide comprising the amino acid sequence of at least a portion of the non-infectious glycoprotein associated with rabies virus, which polypeptide is: a) essentially free of other protein material of viral origin; and b) immunogenic when administered to a mammal so as to elicit formation of antibodies which recognize rabies associated glycoprotein.
Claim 2
Dependent Claim
53 words
A polypeptide comprising the amino acid sequence of at least a portion of the non-infectious glycoprotein associated with rabies virus, which polypeptide is: a) essentially free of other protein material of viral origin; and b) immunogenic when administered to a mammal so as to elicit formation of antibodies which recognize rabies associated glycoprotein.
Claim 3
Dependent Claim
10 words
The polypeptide of claim 1 which is unaccompanied by glycosylation.
Claim 4
Dependent Claim
16 words
The polypeptide of claims 1 or 2 which is essentially free of proteins of mammalian origin.
Claim 5
Dependent Claim
25 words
The polypeptide of claims 1, 2 or 3 which comprises a sequence of the 427-amino acids which are numbered 1 to 427 in Figure 1.
Claim 6
Dependent Claim
25 words
The polypeptide of claims 1, 2 or 3 which comprises the sequence of 505 amino acids which are numbered 1 to 505 in Figure 1.
Claim 7
Dependent Claim
6 words
6 . The polypeptide G 505'
Claim 8
Dependent Claim
6 words
6 . The polypeptide G 505'
Claim 9
Dependent Claim
7 words
7 . The polypeptide G 427 .
Claim 10
Dependent Claim
7 words
7 . The polypeptide G 427 .
Claim 11
Dependent Claim
16 words
The polypeptide of any of the claims 1-7 which is produced by a recombinant host cell.
Claim 12
Dependent Claim
13 words
A DNA sequence which encodes the polypeptide of any of the claims 1-8.
Claim 13
Dependent Claim
19 words
A replicable expression vector capable, in a transformant recombinant host cell, of expressing the DNA sequence of claim 9.
Claim 14
Dependent Claim
9 words
The vector of claim 10 which is a plasmid.
Claim 15
Dependent Claim
17 words
A vector of claim 11 wherein the plasmid is selected from pRabGtrpl, pRabdex2, pRabdex31, pRabGTl, and pRabdexl.
Claim 16
Dependent Claim
13 words
A recombinant host cell transformed with the vector of any of claims 10-12.
Claim 17
Dependent Claim
11 words
A cell culture comprising the recombinant host cells of Claim 13.
Claim 18
Dependent Claim
43 words
A process for producing the expresion vector of claims 10 to 12 which comprises constructing a first DNA sequence encoding the polypeptide and operably linking said first DNA sequence to a second DNA sequence capable of effecting expression of said first DNA sequence.
Claim 19
Dependent Claim
79 words
A process for producing a polypeptide which is immunogenic for antibodies against rabies infection in mammals which process comprises: a) constructing a replicable expression vector comprising a first DNA sequence encoding said polypeptide operably linked to a second DNA sequence capable of effecting the expression of the first DNA sequence; b) transforming host cells with the vector of a); c) growing said host cells under conditions favorable to the expression of the first DNA sequence; d) recovering the polypeptide.
Claim 20
Dependent Claim
79 words
A process for producing a polypeptide which is immunogenic for antibodies against rabies infection in mammals which process comprises: a) constructing a replicable expression vector comprising a first DNA sequence encoding said polypeptide operably linked to a second DNA sequence capable of effecting the expression of the first DNA sequence; b) transforming host cells with the vector of a); c) growing said host cells under conditions favorable to the expression of the first DNA sequence; d) recovering the polypeptide.
Claim 21
Dependent Claim
9 words
The polypeptide produced by the method of claim 16.
Claim 22
Dependent Claim
14 words
A rabies vaccine comprising the polypeptide of any one of claims 1 to 8.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.