Patent EP0114759A2 successfully refreshed from Google Patents.
EP0114759A2
Expired / Lapsed
EP
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Amino acid sequences and polypeptides including these sequences and having the specificity of foot and mouth disease and other viral antigens
Assignee: Individual
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Filing: 1984-01-24
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Granted: —
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Expires: 2004-01-24
Abstract
Abstract An amino acid sequence or a synthetic polypeptide consisting of the same and preferably containing a helical structure is capable of being recognised by two or more antisera raised against different viral strains by virtue of the rotationally and translationally related different aspects presented by the helix to the antibodies. In particular, amino acid sequences of this invention may have rotationally related epitopic sites recognisable by different strains of foot and mouth disease virus.
Inventors
- 👤 Bruce Heywood Nicholson
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 23:32
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; A; A61; A61K; A61K39/00; A61K39/385; C12; C12N; C12N15/00; C12N15/09; C12N15/11; C12N15/62; A61K2039/60; A61K2039/6031; C07K2319/00; C07K2319/61; C07K2319/70; C07K2319/74; C07K2319/75; C12N2770/00; C12N2770/00011; C12N2770/32011; C12N2770/32111; C12N2770/32122
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
77 words
A molecule comprising an amino acid sequence having at least two antigenic regions, each said region being capable of being recognized by antibodies raised against a viral protein sequence, each said region being formed of a chain of amino acids of said sequence, the chains forming said regions having at least one amino acid of said sequence in common, so that the chains at least partly overlap and are not contiguous along the length of the molecule.
Claim 2
Dependent Claim
77 words
A molecule comprising an amino acid sequence having at least two antigenic regions, each said region being capable of being recognized by antibodies raised against a viral protein sequence, each said region being formed of a chain of amino acids of said sequence, the chains forming said regions having at least one amino acid of said sequence in common, so that the chains at least partly overlap and are not contiguous along the length of the molecule.
Claim 3
Dependent Claim
18 words
A molecule according to Claim 1. in which the sequence is such that it adopts a helical conformation.
Claim 4
Dependent Claim
13 words
A molecule according to Claim 1 or Claim 2, which is a polypeptide.
Claim 5
Dependent Claim
25 words
A molecule according to any one of the preceding Claims, in which said sequence is coupled to a larger compound to form a single molecule.
Claim 6
Dependent Claim
22 words
A molecule according to Claim 4, in which said larger compound is keyhole limpet haemocyamin, bovine serum albumin, btg, B-galactosidase or penicillinase.
Claim 7
Dependent Claim
36 words
A molecule according to any one of the preceding Claims, in which said overlap is such that at least 25% of the amino acids in one of said chains form part of the other said chain.
Claim 8
Dependent Claim
25 words
A molecule according to Claim 6, in which at least 50% of the amino acids in said one chain form part of said other chain.
Claim 9
Dependent Claim
25 words
A molecule according to Claim 7, in which at least 75% of the amino acids in said one chain form part of said other chain.
Claim 10
Dependent Claim
22 words
A molecule according to any one of the preceding Claims, in which said sequence is such that it adopts a helical conformation.
Claim 11
Dependent Claim
20 words
A molecule according to Claim 1, in which said sequence comprises the amino acids: Arg-Arg-Gly-Asp-Leu-Gln-Thr-Leu-Ala-Gln-Lys-His-Ala-Arg-His-Leu or an antigenic equivalent thereof.
Claim 12
Dependent Claim
20 words
A molecule according to Claim 1, in which said sequence comprises the amino acids: Arg-Ser-Arg-Gly-Asp-Leu-Gly-Ser-Ile-Ala-Ala-Arg-Val-Ala-Thr-Gln-Leu or an antigenic equivalent thereof.
Claim 13
Dependent Claim
27 words
A molecule according to any one of the preceding Claims, having the antigenicity of two or more different strains or subtypes of foot and mouth disease virus.
Claim 14
Dependent Claim
16 words
A molecule according to Claim 12, in which said strains are O 1 K and C3.
Claim 15
Dependent Claim
14 words
A molecule according to Claim 12, in which said strains are A10 and A12.
Claim 16
Dependent Claim
19 words
A vaccine comprising a molecule according to any one of the preceding Claims together with a carrier or adjuvant.
Claim 17
Dependent Claim
69 words
A synthetic peptide comprising a sequence of amino acids providing at least two antigenic sites, the amino acid sequence giving rise to a first antigenic site being interpolated with other amino acids forming at least part of a second antigenic site so that the amino acids of each site are conformationally contiguous and the peptide is capable of being recognised by two antisera separately raised against different viral strains.
Claim 18
Dependent Claim
69 words
A synthetic peptide comprising a sequence of amino acids providing at least two antigenic sites, the amino acid sequence giving rise to a first antigenic site being interpolated with other amino acids forming at least part of a second antigenic site so that the amino acids of each site are conformationally contiguous and the peptide is capable of being recognised by two antisera separately raised against different viral strains.
Claim 19
Dependent Claim
26 words
A synthetic peptide as claimed in Claim 16, wherein the interpolation of amino acid comprises the sharing of one amino acid by the two antigenic sites.
Claim 20
Dependent Claim
19 words
A vaccine comprising a peptide as defined in Claim 16 or 17 together with an adjuvant or carrier therefor.
Claim 21
Dependent Claim
16 words
A vaccine as claimed in Claim 18, wherein the carrier is covalently linked to the peptide.
Claim 22
Dependent Claim
13 words
A vaccine-according to any one of Claims 15 to 19, formulated for injection.
References Cited (Backward Citations)
No citation records indexed.
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