Patent EP0114577A1 successfully refreshed from Google Patents.
EP0114577A1
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EP
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New pharmaceutical composition
Assignee: Magis Farmaceutici SRL
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Filing: 1983-01-21
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Granted: —
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Expires: 2003-01-21
Abstract
Abstract A new pharmaceutical composition for oral administration of cytidine diphosphate choline ester utilizes liposomes as carrier. In that way hematic levels are obtained which are comparable with those obtained by intravenous administration while taking advantage of an administration way which is more comfortable and more acceptable to patients.
Inventors
- 👤 Adolfo Moroni
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 10:41
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K9/00; A61K9/10; A61K9/127; A61K9/1277; A61K9/1278
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
26 words
1) Pharmaceutical composition for oral administration of cytidine diphosphate choline ester or its salts, characterized in that the active ingredient is carried by means of liposomes.
Claim 2
Dependent Claim
26 words
1) Pharmaceutical composition for oral administration of cytidine diphosphate choline ester or its salts, characterized in that the active ingredient is carried by means of liposomes.
Claim 3
Dependent Claim
19 words
2) Pharmaceutical composition according to claim 1, characterized in that the hydrophobic phase of liposomes is formed by phosphatidylcholine.
Claim 4
Dependent Claim
27 words
3) Pharmaceutical composition according to claim 2, characterized in that the ratio phosphatidilcholine : cytidine diphosphate choline ester ranges from 1 : 1 to 20 : 1.
Claim 5
Dependent Claim
41 words
4) Process for the preparation of a pharmaceutical composition according to any of claims from 1 to 3, characterized in that the solution containing the cytidine diphosphate choline ester is added to globules of the hydrophobic phase previously obtained and lyophilized.
Claim 6
Dependent Claim
41 words
5) Process according to claim 4, characterized in that said globules of the hydrophobic phase are obtained dissolving the component of the hydrophobic phase in a suitable solvent, precipitating by adding acetone, separating the precipitate, dispersing same in water and lyophilizing.
Claim 7
Dependent Claim
37 words
6) Process according to claim 4, characterized in that said globules of the hydrophobic phase are obtained dissolving the component of the hydrophobic phase in a suitable-organic solvent, dispersing in water, evaporating the organic solvent and lyophilizing.
Claim 8
Dependent Claim
36 words
7) Pharmaceutical composition for oral administration of cytidine diphosphate choline ester, characterized in that it is prepared as substantially herein described with particular reference to Examples 1, 2, 3, 4 , 5 , 6 and 7.
Claim 9
Dependent Claim
36 words
7) Pharmaceutical composition for oral administration of cytidine diphosphate choline ester, characterized in that it is prepared as substantially herein described with particular reference to Examples 1, 2, 3, 4 , 5 , 6 and 7.
References Cited (Backward Citations)
GB2074445A
Cited
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