Patent EP0113562A1 successfully refreshed from Google Patents.
EP0113562A1
Expired / Lapsed
EP
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Drug delivery device
Assignee: Elan Corp PLC
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Filing: 1983-12-12
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Granted: —
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Expires: 2003-12-12
Abstract
Abstract A device for transdermal administration of a drug comprises a reservoir containing the drug and a supporting strap, or band, which substantially surrounds a limb of the patient and holds the reservoir in position on a limb of the patient. The reservoir is generally non permeable to the drug, but has a membrane, or plate, of defined surface area through which said drug can pass. In use, this membrane or plate is held against the patient's skin to allow the drug to be absorbed. The device further includes cooperating locking mechanisms for detachably securing the reservoir on the strap or band whereby the supply of drug can be replenished by removing the spent reservoir and inserting a fresh one containing a new supply of the drug.
Inventors
- 👤 Donald Eugene Panoz
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 07:31
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
114 words
A device for the transdermal administration of a drug to a patient comprising a reservoir (11) for the drug from which the drug is supplied to the skin at a pre-determined rate and a support member (21) for said reservoir (11), characterised in that the device (10) includes means (19,20) for attaching the reservoir (11) to said support member (21), said support member (21) being engageable with a face (13) of the reservoir remote from that face (14,15) of the reservoir (11) which is proximal to the skin in use, said support member (21) in use substantially surrounding and being readily detachable from that portion of the body to which the device is applied.
Claim 2
Independent Claim
114 words
A device for the transdermal administration of a drug to a patient comprising a reservoir (11) for the drug from which the drug is supplied to the skin at a pre-determined rate and a support member (21) for said reservoir (11), characterised in that the device (10) includes means (19,20) for attaching the reservoir (11) to said support member (21), said support member (21) being engageable with a face (13) of the reservoir remote from that face (14,15) of the reservoir (11) which is proximal to the skin in use, said support member (21) in use substantially surrounding and being readily detachable from that portion of the body to which the device is applied.
Claim 3
Dependent Claim
54 words
A device according to claim 1, wherein the reservoir (11) comprises a receptacle (12,13) for the drug having an associated drug transfer membrane (15) or plate through which the drug migrates to the skin surface in use, said membrane (15) or plate having a plurality of micropores (16) therethrough or, alternatively, being inherently drug-permeable.
Claim 4
Dependent Claim
20 words
A device according to claim 1 or 2, wherein the drug is carried by an ointment, cream or jelly-like carrier.
Claim 5
Dependent Claim
54 words
A device according to claim 3 when dependent on claim 2, characterised in that the reservoir (11) includes a plate (13) movable in piston-like fashion therein by application of external pressure thereto, resulting in a constant egress of ointment from the reservoir (11) to the skin in use through the drug transfer membrane (15).
Claim 6
Dependent Claim
48 words
A device according to claim 4, characterised in that the means for applying external pressure to the movable plate (13) comprises a spring (24) associated with the support member (21), said spring suitably being a leaf spring (24) having a face (25) which engages the movable plate (13).
Claim 7
Dependent Claim
56 words
A device according to claim 1 or 2, wherein the drug is incorporated in a moulded polymer, wax or polymer/wax block, which is received within the reservoir or, alternatively, comprises said reservoir and which block acts as a carrier for and ensures a sustained release of the drug in use through the associated drug transfer membrane.
Claim 8
Dependent Claim
48 words
A device according to claim 6, wherein the moulded block (34) and the drug transfer membrane (36) are formed as a unit (34, 36) for reception in a cooperating receptacle (31, 32, 33), said unit (34, 36) preferably being a snap-in fit in said receptacle (31, 32, 33).
Claim 9
Independent Claim
27 words
A device according to any one of claims 2-7, wherein the drug transfer membrane is a rate-controlling membrane (34), suitably an ethylene vinylacetate copolymer or polyethylene membrane.
Claim 10
Independent Claim
52 words
A device according to any one of claims 1, 2 or 6-8, characterised in that the reservoir (41) is adapted for reception in a receptacle (46) integral with the support member (47), said reservoir (41) and said receptacle (46) optionally being provided with the respective cooperating components of a suitable locking mechanism.
Claim 11
Independent Claim
57 words
A device according to any preceding claim, characterised in that the device is secured to the site of application by a fastening mechanism integral with the support member, said support member (21) preferably including a pair of straps (22) and the fastening mechanism suitably comprising a buckle mechanism or a system of cooperating hooks and loops (23).
Claim 12
Independent Claim
47 words
A device according to any preceding claim, characterised in that the support member is a watch (51) or bracelet provided on its rear face (50) with a hollow portion or, alternatively a socket defined by an upstanding peripheral wall constituting a receptacle (52) for the drug reservoir.
Claim 13
Independent Claim
28 words
A device according to any preceding claim, characterised in that the support member is an elasticated sweat band which is suitably insulated so as to maintain body temperature.
Claim 14
Independent Claim
22 words
A device according to any preceding claim, wherein the drug is nitroglycerin, isosorbide dinitrate, isosorbide monostearate, clonidine, methadone or scopolamine, especially nitroglycerin.
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