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EP0109562A1
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Succinimide derivatives and their production
Assignee: Sumitomo Chemical Co Ltd
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Filing: 1983-10-20
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Granted: —
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Expires: 2003-10-20
Abstract
Abstract A succinimide derivative of the formula: <IMAGE> wherein A is straight or branched C2-C6 alkylene or alkenylene, B is straight or branched C3-C5 alkylene, D is straight or branched C2-C3 alkylene, E is straight or branched C2-C3 alkylene, R1 and R2 are each hydrogen or C1-C4 alkyl, or they may form a single bond and R3 is a phenyl group optionally substituted with C1-C4 alkyl, C1-C4 alkoxy, halogen and/or trifluoromethyl, a 2-pyridyl group optionally substituted with halogen, a 2-pyrimidyl group optionally substituted with halogen, a group of the formula: <IMAGE> (in which R4 is hydrogen or phenyl), a group of the formula: CO-R5 (in which R5 is adamantyl or furyl) or hydroxy (C2-C4) alkyl, and an acid addition salt thereof, which are useful as anti-anxiety drugs and/or anti-allergic drugs.
Inventors
- 👤 Kikuo Ishizumi
- 👤 Fujio Antoku
- 👤 Yukio Asami
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-07 19:50
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; C07D209/48; A; A61; A61P; A61P25/00; A61P25/20; C07C; C07C51/00; C07C51/54; C07C51/567; C07C61/00; C07C61/08; C07C61/09; C07C61/16; C07C61/22; C07C61/24; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/32; C07D239/42; C07D295/00; C07D295/04; C07D295/06; C07D295/073; C07D401/00; C07D401/02; C07D401/12; C07D403/00; C07D403/02; C07D403/12; C07D403/14
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
150 words
A succinimide derivative of the formula: wherein A is straight or branched C 2 -C 6 alkylene or C 2 -C 6 alkenylene, B is straight or branched C 3 -C 5 alkylene, D is straight or branched-C 2 -C 3 alkylene, E is straight or branched C2 - C3 alkylene, R 1 and R 2 are each hydrogen or C 1 -C 4 alkyl, or they may form a single bond and R 3 is a phenyl group optionally substituted with C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen and/or trifluoromethyl, a 2-pyridyl group optionally substituted with halogen, a 2-pyrimidyl group optionally substituted with halogen, a group of the formula: (in which R 4 is hydrogen or phenyl), a group of the formula: CO -R 5 (in which R 5 is adamantyl or furyl) or hydroxy(C 2 -C 4 )alkyl, and an acid addition salt thereof.
Claim 2
Dependent Claim
150 words
A succinimide derivative of the formula: wherein A is straight or branched C 2 -C 6 alkylene or C 2 -C 6 alkenylene, B is straight or branched C 3 -C 5 alkylene, D is straight or branched-C 2 -C 3 alkylene, E is straight or branched C2 - C3 alkylene, R 1 and R 2 are each hydrogen or C 1 -C 4 alkyl, or they may form a single bond and R 3 is a phenyl group optionally substituted with C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen and/or trifluoromethyl, a 2-pyridyl group optionally substituted with halogen, a 2-pyrimidyl group optionally substituted with halogen, a group of the formula: (in which R 4 is hydrogen or phenyl), a group of the formula: CO -R 5 (in which R 5 is adamantyl or furyl) or hydroxy(C 2 -C 4 )alkyl, and an acid addition salt thereof.
Claim 3
Dependent Claim
47 words
The succinimide derivative as claimed in claim 1, which is a compound of the formula: wherein n is an integer of 3 to 5 and A, R 1 , R 2 and R 3 are each as defined in claim 1, and an acid addition salt thereof.
Claim 4
Dependent Claim
77 words
The succinimide derivative as claimed in claim 1, which is a compound of the formula: wherein n is an integer of 3 to 5, R 6 , R 7 , R 8 and R 9 are each hydrogen or methyl, a full line accompanyig a broken line ( ) indicates a single or double bond and R 1 , R 2 and R 3 are each as defined in claim 1, and an acid addition salt thereof.
Claim 5
Dependent Claim
73 words
The succinimide derivative as claimed in claim 1, which is a compound of the formula: wherein n is in integer of 3 to 5, R 7 is hydrogen or methyl and R 10 is a phenyl group optionally substituted with C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogen and/or trifluoromethyl, a 2-pyridiyl group optionally substituted with halogen or a 2-pyrimidyl group optionally substituted halogen, and an acid addition salt thereof.
Claim 6
Dependent Claim
142 words
A process for preparing the succinimide derivative as claimed in claim 1, which comprises (a) reacting an acid anhydride of the formula: wherein A, R 1 and R 2 are each as defined in claim I with a reagent of the formula: wherein B, D, E and R are each as defined in claim 1; (b) reacting an imide of the formula: wherein A, R 1 and R 2 are each as defined in claim 1 with a reagent of the formula: wherein B, D, E and R 3 are each as defined above and X is a leaving group; or (c) reacting a substituted imine of the formula: wherein A, B , R 1 , R 2 and X are each as defined above with a reagent of the formula: wherein D, E and R 3 are each as defined above.
Claim 7
Dependent Claim
34 words
A pharmaceutical composition which comprises as an active ingredient a pharmaceutically effective amount of at least one of the compounds claimed in claim 1 and at least one pharmaceutically acceptable inert carrier or diluent.
Claim 8
Dependent Claim
16 words
Use of the compound according to claim 1 as an anti-anxiety drug or an anti-allergic drug.
References Cited (Backward Citations)
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