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EP0106004A1
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Method of forming a hydrophilic coating on a substrate
Assignee: Astra Tech AB
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Filing: 1982-10-14
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Granted: —
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Expires: 2002-10-14
Abstract
Abstract A method of forming a hydrophilic coating on a substrate comprised of applying a hydrophilic copolymer capable of chemical reacting with a coupling agent which will promote adhesion to the substrate. A polyisocyanate coupling agent is applied to the surface from a solvent solution. In certain instances, the copolymer and isocyanate can be simultaneously applied from a solvent solution. The resulting hydrophilic coating is thrombo resistant, biocompatible and stable.
Inventors
- 👤 R. Alastair Winn
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 20:06
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; A61L29/00; A61L29/08; A61L29/085; A61L31/00; A61L31/08; A61L31/10; A61L33/00; A61L33/0076; A61L33/0088; A61L33/06; A61L33/064; A61L33/066; B; B05; B05D; B05D7/00; B05D7/02; C; C08; C08G; C08G18/00; C08G18/06; C08G18/28; C08G18/40; C08G18/62; C08G18/6283; C08J; C08J7/00; C08J7/04; C08J7/0427; C08J7/043; C08J7/056; C08J7/12; C09; C09K; C09K3/00; C09K3/18; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/544; C08J2439/00; Y; Y10; Y10T; Y10T428/00; Y10T428/31504; Y10T428/31551; Y10T428/31562; Y10T428/31573; Y10T428/31576; Y10T428/3158
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
45 words
A method of forming a hydrophilic coating on a substrate, preferably a biomedical substrate, characterized in: forming unreacted isocyanate groups on the surface of the substrate; treating the surface of the substrate with a hydrophilic copolymer adapted to form covalent bonds with the unreacted isocyanate.
Claim 2
Independent Claim
45 words
A method of forming a hydrophilic coating on a substrate, preferably a biomedical substrate, characterized in: forming unreacted isocyanate groups on the surface of the substrate; treating the surface of the substrate with a hydrophilic copolymer adapted to form covalent bonds with the unreacted isocyanate.
Claim 3
Dependent Claim
66 words
A method according to claim 1, characterized in: applying a coating from a solvent solution comprised of a polyisocyanate to the surface of said substrate to form a coupling coating with unreacted isocyanates; applying a solvent solution comprised of a hydrophilic copolymer which will react with isocyanate to form a covalent bond between said coupling coating and hydrophilic copolymer; -evaporating the solvent and reacting said isocyanates.
Claim 4
Dependent Claim
36 words
A method according to claim 1, characterized in simultaneously applying solvent solution containing polyisocyanate and hydrophilic copolymer which will form covalent bonds when reacted with isocyanates, eliminating the solvent and reacting said polyisocyanate and reactive copolymer.
Claim 5
Dependent Claim
22 words
A method according to claim 3, characterized in that said solvent solution includes a reactive diluent which is subsequently polymerized in situ.
Claim 6
Dependent Claim
19 words
A method according to claim 4, characterized in that said diluent in said solution is up to about 100%.
Claim 7
Dependent Claim
42 words
A method according to claim 4 or 5, characterized in that said reactive diluent is a UV cured vinyl containing monomer, dimer or trimer preferably selected from the group consisting of hydroxymethyl methacrylate, N-vinyl-2-pyrrolidone, hydroxypropyl methacrylate, acrylic acid, methacrylic acid and acrylamide.
Claim 8
Dependent Claim
46 words
A method according to claim 2 or 3, characterized in that said substrate is a polymer substrate selected from the group consisting of a polyurethane resin, a vinyl resin, a polyacrylate, a polycarbonate, a polyester and rubber, such as latex rubber, polyisoprene and butadiene styrene copolymer.
Claim 9
Dependent Claim
19 words
A method according to claim 4, characterized in that a solvent is selected which will not react with isocyanates.
Claim 10
Dependent Claim
28 words
A method according to claim 4 or 8, characterized in that the substrate is selected from the group consisting of vinyl or butadiene styrene rubber, polyethylene and polypropylene.
Claim 11
Dependent Claim
35 words
A method according to claim 9, characterized in treating the substrate with chemical modifiers from the group consisting of gamma amino propyl functional silanes and ozone or with a plasma discharge or high radiation energy.
Claim 12
Dependent Claim
37 words
A method according to claim 1, characterized in that said polyisocyanate is selected from the group consisting of polymethylenepolyphenyl isocyanate, 4,4'-diphenylmethane diisocyanate and position isomers thereof, 2,4-toluene diisocyanate and position isomers thereof, 3,4-dichlorophenyl diisocyanate and isoferrone isocyanate.
Claim 13
Dependent Claim
33 words
A method according to claim 1, characterized in that said polyisocyanate is a blocked isocyanate, preferably a member selected from the group consisting of phenol blocked diphenyl methane 4,4'-diisocyanate, and ketoxime blocked tetraisocyanate.
Claim 14
Independent Claim
35 words
A method according to any of claims 2, 11 or 12, characterized in that said polyisocyanate is applied from solvent solution containing at least about 0.1% W/V, preferably from about 0.3% to about 15% W/V.
Claim 15
Dependent Claim
31 words
A method according to claim 2, characterized in that said polyisocyanate solution is in contact with said substrate less than about 120 minutes, e.g. 5-20 minutes, such as approximately 10 minutes.
Claim 16
Dependent Claim
20 words
A method according to claim 1, characterized in that the copolymer has a molecular weight average of at least 100,000.
Claim 17
Dependent Claim
26 words
A method according to claim 1 or 15, characterized in that said copolymer has an average of at least two active hydrogen atom sites per molecule.
Claim 18
Dependent Claim
29 words
A method according to claim 16, characterized in that said copolymer is swellable in an aqueous medium and-preferably also soluble in non-aqueous solvents which do not react with isocyanate.
Claim 19
Dependent Claim
21 words
A method according to claim 16, characterized in that said copolymer consists primarily of repeating units containing no reactive hydrogen atoms.
Claim 20
Dependent Claim
37 words
A method according to claim 16, characterized in that the monomers of said copolymer are selected from the group consisting of vinyl methyl ether, vinyl pyridine, N-vinyl-2-pyrrolidone, acrylamide, hydroxyethyl acrylate, acrylic acid, hydroxypropyl methacrylate and nydroxyethyl methacrylate.
Claim 21
Dependent Claim
54 words
A biomedical product having a hydrophilic coating characterized in that it comprises: a substrate; a hydrophilic copolymer coating; coating retention means for retaining said hydrophilic coating on said substrate by a covalent bond, said copolymer having an average of at least two or more sites capable of covalently bonding to a polyisocyanate coupling coating.
Claim 22
Dependent Claim
54 words
A biomedical product having a hydrophilic coating characterized in that it comprises: a substrate; a hydrophilic copolymer coating; coating retention means for retaining said hydrophilic coating on said substrate by a covalent bond, said copolymer having an average of at least two or more sites capable of covalently bonding to a polyisocyanate coupling coating.
Claim 23
Dependent Claim
43 words
A product according to claim 20, characterized in that said substrate is a polymer substrate selected from the group consisting of a polyurethane resin, a vinyl resin, a polyacrylate, a polycarbonate, a polyester and rubber, such as latex rubber, polyisoprene, or styrene butadiene.
Claim 24
Dependent Claim
41 words
A product according to claim 20, characterized in that said substrate comprises a medical instrument adapted for blood or subcutaneous tissue contact, for instance an intravenous tube, a wound drain or a surgical tool, such as a stainless steel surgical tool.
References Cited (Backward Citations)
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