Patent EP0089937A1 successfully refreshed from Google Patents.
EP0089937A1
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EP
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Apparatus and method for serial dilution of liquid samples
Assignee: Individual
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Filing: 1983-03-22
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Granted: —
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Expires: 2003-03-22
Abstract
Abstract An apparatus for serial dilution of liquid samples comprises a power-driven measuring valve (11) having a rotatably mounted valve body (23) provided with a single calibrated measuring passageway (35). During a dilution cycle the measuring passageway (35) in different rotational positions of the valve body (23) successively isolates a measured volume of a sample to be diluted and an equal volume of a first diluted solution of the sample which has been prepared by mixing the isolated undiluted volume of the sample with a measured volume of diluent. In a valve body position between said different rotational positions the measuring passageway (35) is connected to form part of a rinsing flow system (56,58).
Inventors
- 👤 Erik Öhlin
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 13:21
CPC Classifications
G; G01; G01N; G01N1/00; G01N1/28; G01N1/38; B; B01; B01F; B01F35/00; B01F35/71; B01F35/714; B01F35/7141; B01F35/71411; B01F35/714112; Y; Y10; Y10T; Y10T137/00; Y10T137/8593; Y10T137/86493; Y10T137/86831; Y10T436/00; Y10T436/11; Y10T436/119163; Y10T436/25; Y10T436/25625; Y10T436/2575
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
342 words
Valve device for use in apparatus for serial dilution of liquid samples, comprising a valve housing (20) having a sample inlet (36) connectable to a source of liquid sample, a diluent inlet (46/51) connectable to a source (17) of liquid diluent, a first outlet (49/50) connectable to a first sample recipient (33), a third inlet (40) connectable to the first sample recipient, a second outlet (43/44) connectable to a second sample recipient (45), and first (38/42) and second (46/51) pump connection ports connectable to pump means for conveying liquid sample and diluent within the valve device, a valve body (23) mounted in the housing for movement therein and having a volumetrically calibrated passageway system opening into opposite sides of the valve body and movable to different positions to provide fluid flow communication between, on the one hand, the pump connection ports and, on the other hand, the inlets and outlets, and a valve body actuator (26) for moving the valve body (23) relative to the housing (20), characterised in that the passageway system comprises a single passageway (35) which in a first valve body position (FIG. 3) connects the sample inlet (36) with the first pump connection port (38/42), in a second valve body position (FIG. 4) connects the second pump connection port (46/51) with the first outlet (49/50), in a third valve body position (FIG. 7) connects the third inlet (40) with the first pump connection port (38/42), and in a fourth valve body position (FIG. 8) connects the second pump connection port (46/51) with the second outlet (43/44), and the housing (20) has recesses (54/55) which are open towards said opposite valve body sides and in register with the path along which the ends of the passageway (35) move during movement of the valve body (23) between the second and third valve body positions, and which are connectable with a wash liquid conveying system (14, 56-59) and in at least one valve body position (FIG. 5) between the second and third valve body positions communicate simultaneously with the passageway (35).
Claim 2
Dependent Claim
342 words
Valve device for use in apparatus for serial dilution of liquid samples, comprising a valve housing (20) having a sample inlet (36) connectable to a source of liquid sample, a diluent inlet (46/51) connectable to a source (17) of liquid diluent, a first outlet (49/50) connectable to a first sample recipient (33), a third inlet (40) connectable to the first sample recipient, a second outlet (43/44) connectable to a second sample recipient (45), and first (38/42) and second (46/51) pump connection ports connectable to pump means for conveying liquid sample and diluent within the valve device, a valve body (23) mounted in the housing for movement therein and having a volumetrically calibrated passageway system opening into opposite sides of the valve body and movable to different positions to provide fluid flow communication between, on the one hand, the pump connection ports and, on the other hand, the inlets and outlets, and a valve body actuator (26) for moving the valve body (23) relative to the housing (20), characterised in that the passageway system comprises a single passageway (35) which in a first valve body position (FIG. 3) connects the sample inlet (36) with the first pump connection port (38/42), in a second valve body position (FIG. 4) connects the second pump connection port (46/51) with the first outlet (49/50), in a third valve body position (FIG. 7) connects the third inlet (40) with the first pump connection port (38/42), and in a fourth valve body position (FIG. 8) connects the second pump connection port (46/51) with the second outlet (43/44), and the housing (20) has recesses (54/55) which are open towards said opposite valve body sides and in register with the path along which the ends of the passageway (35) move during movement of the valve body (23) between the second and third valve body positions, and which are connectable with a wash liquid conveying system (14, 56-59) and in at least one valve body position (FIG. 5) between the second and third valve body positions communicate simultaneously with the passageway (35).
Claim 3
Dependent Claim
54 words
Valve device according to claim 1, characterised in that each recess (54,55) is elongated and extends along said path over a major portion of the space separating the second and third positions, and in that the width of the recesses is larger than the width of the respective adjacent end of the passageway (35).
Claim 4
Dependent Claim
27 words
Valve device according to claim 1 or 2, characterised in that opposite ends of each recess (54,55) have respectively an outlet and an inlet for wash liquid.
Claim 5
Dependent Claim
185 words
Apparatus according to claim 2, characterised in that each recess (54,55) has spaced inlet and outlet ends, the inlet end of one (55) of the recesses is connected to a wash liquid inlet (56), the outlet end of said one recess (55) is in fluid flow communication with the inlet end of the other recess (54), the outlet end of said other recess (54) is connected to a wash liquid outlet (59), and the resistance to fluid flow of the flow path formed by the recesses (54,55) and the fluid flow connection between the outlet end of said one recess (55) and the inlet end of said other recess (54) is substantially smaller than the resistance to fluid flow of the flow path which, with the ends of the passageway (35) registering with the recesses (54,55), is formed by the portion of said one recess (55) situated between the inlet end of said one recess (55) and the passageway (35), the passageway (35), and the portion of said other recess (54) situated between the passageway (35) and the outlet end of said other recess (54).
Claim 6
Dependent Claim
136 words
Method of serially diluting a liquid sample, comprising the steps of preparing a first diluted solution by mixing a measured first volume of sample with a measured first volume of diluent, the measured first volume of diluent being many times the measured first volume of sample, and preparing a second diluted solution by isolating from the first diluted solution a measured second volume of the first diluted solution and mixing the measured second volume with a measured second volume of diluent, characterised in that the measured second volume of the first diluted solution and the measured second volume of diluent are respectively equal to the measured first volume of sample and the measured first volume of diluent, and in that the remainder of the first diluted solution is mixed with a measured third volume of diluent.
Claim 7
Dependent Claim
136 words
Method of serially diluting a liquid sample, comprising the steps of preparing a first diluted solution by mixing a measured first volume of sample with a measured first volume of diluent, the measured first volume of diluent being many times the measured first volume of sample, and preparing a second diluted solution by isolating from the first diluted solution a measured second volume of the first diluted solution and mixing the measured second volume with a measured second volume of diluent, characterised in that the measured second volume of the first diluted solution and the measured second volume of diluent are respectively equal to the measured first volume of sample and the measured first volume of diluent, and in that the remainder of the first diluted solution is mixed with a measured third volume of diluent.
References Cited (Backward Citations)
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