Patent EP0085166B1 successfully refreshed from Google Patents.
EP0085166B1
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EP
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A filter and a process for the preparation thereof
Assignee: New York Blood Center
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Filing: 1982-12-15
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Granted: 1986-06-25
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Expires: 2002-12-15
Abstract
No abstract record available.
Inventors
- 👤 Birger Blomback
- 👤 Masahisa Okada
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-03 17:43
CPC Classifications
B; B01; B01J; B01J31/00; B01J31/003; A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/15; B01D; B01D39/00; B01D69/00; B01D69/10; B01D69/107; B01D69/1071; B01D71/00; B01D71/06; B01D71/74; B01J31/02; B01J31/06; B01J35/00; B01J35/50; B01J35/56; C; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/755; C12; C12N; C12N1/00; C12N1/02; C12N11/00; C12N11/02; C12N11/04; C12N7/00; A61K38/00; C12N2760/00; C12N2760/00011; C12N2760/18011; C12N2760/18811; C12N2760/18851; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 42
Claim 1
Independent Claim
38 words
A filter comprising fibrin in gel form, said gel having substantially uniform pore sizes, said filter comprising means for retaining the shape of at least one surface of said gel against deformation when contacted by a flowing medium.
Claim 2
Dependent Claim
38 words
A filter comprising fibrin in gel form, said gel having substantially uniform pore sizes, said filter comprising means for retaining the shape of at least one surface of said gel against deformation when contacted by a flowing medium.
Claim 3
Dependent Claim
15 words
A filter according to claim 1 wherein said shape-retaining means comprises a foraminous sheet member.
Claim 4
Dependent Claim
15 words
A filter according to claim 2 wherein said foraminous sheet member comprises a fibrous network.
Claim 5
Dependent Claim
13 words
A filter according to claim 3 wherein said network comprises a woven fabric.
Claim 6
Dependent Claim
13 words
A filter according to claim 3 wherein said network comprises a knitted fabric.
Claim 7
Dependent Claim
13 words
A filter according to claim 3 wherein said network comprises a non-woven fabric.
Claim 8
Dependent Claim
25 words
A filter according to claim 3 wherein said fibrous network comprises a sheet containing silk, nylon, cellulose, cotton, a natural fiber or a synthetic fiber.
Claim 9
Dependent Claim
19 words
A filter according to claim 1 wherein said shape-retaining means comprises a plurality of wires which intersect one another.
Claim 10
Dependent Claim
25 words
A filter according to claim 8 wherein said wires are in the form of a wire screen, a wire mesh or an expanded wire sheet.
Claim 11
Dependent Claim
12 words
A filter according to claim 8 wherein said wires are metal wires.
Claim 12
Dependent Claim
21 words
A filter according to claim 1 wherein the average effective pore size of said fibrin gel is 0,003 to 1,0 µm.
Claim 13
Dependent Claim
21 words
A filter according to claim 11 wherein the average effective pore size of said fibrin gel is 0,009 to 0,3 pm.
Claim 14
Dependent Claim
23 words
A filter according to claim 1 wherein said fibrin gel is a crosslinked fibrin gel and said shape-retaining means is a cross-linking agent.
Claim 15
Dependent Claim
22 words
A filter according to claim 13 wherein said crosslinking agent is selected from the group consisting of dialdehydes, azides, aromaticdihalides, and bis-imidates.
Claim 16
Dependent Claim
12 words
A filter according to claim 13 wherein said crosslinking agent is glutardialdehyde.
Claim 17
Dependent Claim
11 words
A filter according to claim 2 wherein said gel is crosslinked.
Claim 18
Dependent Claim
11 words
A filter according to claim 3 wherein said gel is crosslinked.
Claim 19
Dependent Claim
19 words
A filter according to claim 1 wherein said gel has disposed on at least its upper surface a shape-retaining.
Claim 20
Dependent Claim
19 words
A filter according to claim 18 wherein said gel has disposed on its lower surface a second shape-retaining means.
Claim 21
Dependent Claim
15 words
A filter according to claim 19 wherein said second shape-retaining means comprises a foraminous sheet.
Claim 22
Dependent Claim
16 words
A filter according to claim 1 wherein said gel is adhesively secured to said shape-retaining means.
Claim 23
Dependent Claim
15 words
A filter according to claim 1 wherein said gel is grafted to said shape-retaining means.
Claim 24
Dependent Claim
26 words
A filter according to claim 2 wherein said shape-retaining means is a foraminous member having pores or openings of a size of 0,01 to 5 mm.
Claim 25
Dependent Claim
39 words
A process for preparing a filter according to claim 1 wherein a fibrinogen solution with pre-adjusted clothing parameters is mixed with a coagulation enzyme and the resulting mixture is made to clot in a form intended for the filter.
Claim 26
Dependent Claim
27 words
A process according to claim 24 wherein said coagulation enzyme is selected from the group consisting of thrombin, Batroxobin, Arvin, Eccarin, Papain, Staphylocoagulase, Trypsin, caterpiller venom enzyme.
Claim 27
Dependent Claim
25 words
A process according to claim 24 wherein said fibrinogen is brought in contact with said enzyme in the presence of at least one calcium ion.
Claim 28
Dependent Claim
21 words
A process according to claim 26 wherein the calcium ion concentration in the gel formation mixture is up to 20 mM.
Claim 29
Dependent Claim
23 words
A process according to claim 24 wherein the enzyme is thrombin and the gel is prepared in the absence of a calcium ion.
Claim 30
Dependent Claim
11 words
A process according to claim 26 wherein said enzyme is Batroxobin.
Claim 31
Dependent Claim
77 words
A process for separating a first substance having a size of 0,003 to 1 pm from a second substance with which it is in admixture, said second substance having a larger size than said first substance, which comprises passing said mixture of said first substance and said second substance over a filter according to claim 1 wherein said gel having pores of a size to permit passage therethrough of said first substance but excluding said second substance.
Claim 32
Dependent Claim
24 words
A process according to claim 30 wherein said gel is used with substantially uniform pore sizes in the range of 0,009 to 0,3 pm.
Claim 33
Dependent Claim
25 words
A process according to claim 30 wherein at least one component of blood is separated from another component by passing said blood over said filter.
Claim 34
Dependent Claim
27 words
A process according to claim 30 wherein at least one component of blood plasma is removed from another component by passing said blood plasma over said filter.
Claim 35
Dependent Claim
17 words
A process according to claim 33 wherein blood platelets are separated from blood plasma containing blood platelets.
Claim 36
Dependent Claim
27 words
A process according to claim 30 wherein at least one component of a mammalian liver is separated from another component by passing the mixture over said filter
Claim 37
Dependent Claim
14 words
A process according to claim 35 wherein mitochondia are separated from liver cell fragments.
Claim 38
Dependent Claim
19 words
A process according to claim 30 wherein a virus is separated from components within which it is in admixture.
Claim 39
Dependent Claim
11 words
A process according to claim 37 wherein said virus is Sendai-virus.
Claim 40
Dependent Claim
19 words
A process according to claim 30 wherein a bacterium is separated from components within which it is in admixture.
Claim 41
Dependent Claim
12 words
A process according to claim 39 wherein said bacterium is E. coli.
Claim 42
Dependent Claim
17 words
A process according to claim 30 wherein said gel is formed in the presence of Factor XIII.
References Cited (Backward Citations)
No citation records indexed.
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