Patent EP0084705A2 successfully refreshed from Google Patents.
EP0084705A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Process for preparing solid shaped articles
Assignee: John Wyeth and Brother Ltd
•
Filing: 1982-11-19
•
Granted: —
•
Expires: 2002-11-19
Abstract
Abstract Solid shaped articles, particularly rapidly dissolving pharmaceutical dosage forms, carrying predetermined unit quantities of chemicals are prepared by a novel process involving the addition of the predetermined amount of chemical in a solvent to a placebo article which contains a network of carrier material. The placebo article is prepared by freezing a composition of carrier material in a solvent and subliming the solvent from the frozen composition.
Inventors
- 👤 Ian Richard Buxton
- 👤 Harold Feldman
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 20:19
CPC Classifications
A; A61; A61K; A61K9/00; F; F26; F26B; F26B5/00; A01; A01N; A01N25/00; A01N25/34; A61K9/0012; A61K9/0053; A61K9/0056; A61K9/20; A61K9/2095
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
91 words
A process for preparing a solid shaped article carrying a predetermined unit quantity of a chemical, which process comprises freezing a composition comprising a solution in a first solvent of a water-soluble or water-dispersible carrier material that is inert towards the chemical, subliming the first solvent from the frozen composition so as to produce a product having a network of carrier material, adding to said product a solution or suspension of a second non-aqueous solvent containing the predetermined amount of the chemical and allowing or causing the second solvent to evaporate.
Claim 2
Dependent Claim
91 words
A process for preparing a solid shaped article carrying a predetermined unit quantity of a chemical, which process comprises freezing a composition comprising a solution in a first solvent of a water-soluble or water-dispersible carrier material that is inert towards the chemical, subliming the first solvent from the frozen composition so as to produce a product having a network of carrier material, adding to said product a solution or suspension of a second non-aqueous solvent containing the predetermined amount of the chemical and allowing or causing the second solvent to evaporate.
Claim 3
Dependent Claim
40 words
A process as claimed in Claim 1 wherein the composition is frozen in a mould corresponding to the size and shape of the desired shaped article and the first solvent is sublimed while the frozen composition is in the mould.
Claim 4
Dependent Claim
28 words
A process as claimed in Claim 2 wherein the second solvent containing the chemical is added to the sublimed product while the sublimed product is in the mould.
Claim 5
Dependent Claim
19 words
A process as claimed in Claim 3 wherein the mould is a depression in a sheet of filmic material.
Claim 6
Dependent Claim
36 words
A process as claimed in Claim 4 wherein a covering sheet is adhered to the filmic material after the chemical is added to the sublimed product so as to produce a package enclosing the shaped article.
Claim 7
Dependent Claim
52 words
A process as claimed in Claim 1 wherein the composition is frozen in a mould corresponding to the size and shape of more than one shaped article and the sublimed product is sub-divided to the desired size and shape prior or subsequent to the addition of the second solvent containing the chemical.
Claim 8
Dependent Claim
19 words
A process as claimed in any one of the preceding claims wherein the carrier material is partially hydrolysed gelatin.
Claim 9
Dependent Claim
27 words
A process as claimed in Claim 7 wherein the second solvent is one or more solvents selected from the group consisting of chloroform, dichloromethane, trichloroethylene and isopropanol.
Claim 10
Dependent Claim
18 words
A process as claimed in any one of Claims 1 to 6 wherein the carrier material is dextran.
Claim 11
Dependent Claim
30 words
A process as claimed in Claim 9 wherein the second solvent is one or more solvents selected from the group consisting of acetone, ethanol, chloroform, diethyl ether, dichloroethane and isopropanol.
Claim 12
Dependent Claim
27 words
A process as claimed in any one of the preceding claims wherein the chemical is a pharmaceutical substance and the shaped article is a pharmaceutical dosage form.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.