Patent EP0082789A2 successfully refreshed from Google Patents.
EP0082789A2
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EP
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Immunological composition and method for hepatitis B virus
Assignee: Baylor College of Medicine
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Filing: 1982-12-21
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Granted: —
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Expires: 2002-12-21
Abstract
Abstract A composition for eliciting production of antibody to hepatitis B surface antigen and method of neutralizing the infectivity of hepatitis type B virus. A cyclic polypeptide is prepared having a disulfide bond in a hydrophilic region, namely residues 117-137 or 122-137 and an amino acid sequence unique from that associated with the native 25,000 molecular weight polypeptide derived from hepatitis B surface antigen.
Inventors
- 👤 Gordon Ronald Dreesman
- 👤 James Thomas Sparrow
- 👤 Darrell Lynn Peterson
- 👤 Frederick Blaine Hollinger
- 👤 Joseph Louis Melnick
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-27 20:05
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; A; A61; A61P; A61P37/00; C12; C12N; C12N2730/00; C12N2730/00011; C12N2730/10011; C12N2730/10111; C12N2730/10122
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
20 words
A composition of matter comprising a cyclic synthetic peptide having a disulfide bond in a hydrophilic region of said peptide.
Claim 2
Dependent Claim
20 words
A composition of matter comprising a cyclic synthetic peptide having a disulfide bond in a hydrophilic region of said peptide.
Claim 3
Dependent Claim
31 words
The composition of matter of claim 1 wherein the peptide is one selected from a group consisting of a molecule having 16 amino acids and a molecule having 21 amino acids.
Claim 4
Dependent Claim
18 words
The composition of matter of claim 1 wherein the disulfide bond is in the region of residues 122-137.
Claim 5
Dependent Claim
18 words
The composition of matter of claim 1 wherein the disulfide bond is in the region of residues 117-137.
Claim 6
Dependent Claim
18 words
The composition of matter of claim 1 wherein the cyclic peptide includes the following amino acid sequence :
Claim 7
Dependent Claim
18 words
The composition of matter of claim 1 wherein the cyclic peptide includes the following amino acid sequence :
Claim 10
Dependent Claim
29 words
A composition for use as an immunizing preparation specific to hepatitis B virus comprising a cyclic synthetic peptide having a disulfide bond in a hydrophilic region of said peptide.
Claim 11
Dependent Claim
29 words
A composition for use as an immunizing preparation specific to hepatitis B virus comprising a cyclic synthetic peptide having a disulfide bond in a hydrophilic region of said peptide.
Claim 12
Dependent Claim
28 words
A composition for eliciting production of antibody to hepatitis B surface antigen comprising a cyclic synthetic peptide having a disulfide bond in a hydrophilic region of said peptide.
Claim 13
Dependent Claim
28 words
A composition for eliciting production of antibody to hepatitis B surface antigen comprising a cyclic synthetic peptide having a disulfide bond in a hydrophilic region of said peptide.
Claim 14
Dependent Claim
34 words
A composition for eliciting antibody response to hepatitis B surface antigen comprising a cyclic synthetic peptide having a disulfide bond in the region of residues selected from the group consisting of 117-137 and 122-137.
Claim 15
Dependent Claim
34 words
A composition for eliciting antibody response to hepatitis B surface antigen comprising a cyclic synthetic peptide having a disulfide bond in the region of residues selected from the group consisting of 117-137 and 122-137.
Claim 16
Dependent Claim
15 words
The composition of claim 9 wherein the cyclic peptide consists of 16 amino acid residues.
Claim 17
Dependent Claim
15 words
The composition of claim 9 wherein the cyclic peptide consists of 21 amino acid residues.
Claim 18
Dependent Claim
16 words
The composition of claim 10 wherein the cyclic peptide includes the following amino acid sequence :
Claim 19
Dependent Claim
16 words
The composition of claim 11 wherein the cyclic peptide includes the following amino acid sequence :
Claim 20
Independent Claim
34 words
A method for eliciting production of antibody to hepatitis B surface antigen comprising introducing into a host containing the antigen a cyclic peptide having a disulfide bond in a hydrophilic region of said peptide.
Claim 21
Independent Claim
34 words
A method for eliciting production of antibody to hepatitis B surface antigen comprising introducing into a host containing the antigen a cyclic peptide having a disulfide bond in a hydrophilic region of said peptide.
Claim 22
Independent Claim
33 words
A method for eliciting antibody response to hepatitis B surface antigen, comprising, introducing into a host containing the antigen a cyclic peptide having a disulfide bond in a hydrophilic region of said peptide.
Claim 23
Independent Claim
33 words
A method for eliciting antibody response to hepatitis B surface antigen, comprising, introducing into a host containing the antigen a cyclic peptide having a disulfide bond in a hydrophilic region of said peptide.
Claim 24
Dependent Claim
15 words
The method of claim 15 wherein the cyclic polypeptide consists of 16 amino acid residues.
Claim 25
Dependent Claim
15 words
The method of claim 15 wherein the cyclic peptide consists of 21 amino acid residues.
Claim 26
Dependent Claim
16 words
The method of claim 16 wherein the cyclic peptide includes the following amino acid sequence :
Claim 27
Dependent Claim
16 words
The method of claim 17 wherein the cyclic peptide includes the following amino acid sequence :
Claim 28
Independent Claim
17 words
The method of claims 18 or 19 wherein the cyclic peptide is combined with an adjuvant vehicle.
Claim 29
Independent Claim
22 words
The method of claims 18 or 19 wherein the adjuvant vehicle is selected from the group consisting of alum, liposomes or micelles.
Claim 30
Independent Claim
44 words
A method for detecting the presence of antibody to hepatitis B surface antigen in a clinical specimen comprising adding said specimen to a cyclic synthetic peptide on a solid phase support, said peptide having a disulfide bond in a hydrophilic region of said peptide.
Claim 31
Independent Claim
44 words
A method for detecting the presence of antibody to hepatitis B surface antigen in a clinical specimen comprising adding said specimen to a cyclic synthetic peptide on a solid phase support, said peptide having a disulfide bond in a hydrophilic region of said peptide.
Claim 32
Dependent Claim
29 words
The method of claim 22 wherein the peptide is one selected from a group consisting of a molecule having 16 amino acids and a molecule having 21 amino acids.
Claim 33
Dependent Claim
16 words
The method of claim 22 wherein the disulfide bond is in the region of residues 122-137.
Claim 34
Dependent Claim
16 words
The method of claim 22 wherein the disulfide bond is in the region of residues 117-137.
Claim 35
Dependent Claim
16 words
The method of claim 22 wherein the cyclic peptide includes the following amino acid sequence :
Claim 36
Independent Claim
42 words
A method for the identification of the native antigenic determinants (epitopes) associated with an infectious agent through the competition of synthetic peptide and anti-idiotype reagents produced to the common idiotype of naturally acquired antibody produced by the host to the infectious agent.
Claim 37
Independent Claim
42 words
A method for the identification of the native antigenic determinants (epitopes) associated with an infectious agent through the competition of synthetic peptide and anti-idiotype reagents produced to the common idiotype of naturally acquired antibody produced by the host to the infectious agent.
Claim 38
Dependent Claim
31 words
The method of claim 27 wherein the epitope associated with the synthetic peptide can be characterized with the use of monoclonal antibodies prepared to the antigen associated with the infectious agent.
References Cited (Backward Citations)
No citation records indexed.
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