Optically uniform beta-lactams, their preparation and use in the preparation of antimicrobial beta-lactams, and starting compounds for use in their preparation

Abstract

Abstract There is presented optically uniform beta -lactams of the formulae <IMAGE> wherein Z is a readily cleavable acyl group, R1 is amino or a group convertible into amino, R2 is hydrogen or a readily cleavable protecting group and R3 and R4 each are a lower hydrocarbon group which optionally contains oxygen and which is attached via a carbon atom, whereby these groups can also be joined with one another to form a ring, with the proviso that R1 is a readily cleavable acylamino when R2 is hydrogen, and the corresponding optical antipodes, their manufacture and use in the manufacture of antimicrobially-active beta -lactams as well as novel intermediates usable in their manufacture.

Inventors

• 👤 Christian Nicolas Dr. Hubschwerlen
• 👤 Gérard Dr. Schmid

Bibliographic Details