Medicine for the treatment of diabetes

Claim 3

The method according to claim 1, characterised in that said synthetic phenyl ester type chymotrypsin inhibitor is a compound represented by the following formula or an acid addition salt thereof, wherein R: indole which may be substituted with lower alkyl and/or lower alkoxy; naphthyl which may be substituted with lower alkoxy and which may be partially saturated with 2 or 4 hydrogen atoms; phenyl which may be substituted with lower alkyl, alkoxy, alkoxycarbonyloxy; acyl, acyloxy or halogen; cyclohexyl; or indane or furyl; A: a single bond, alkylene or vinylene; P: a single bond, alkylene, vinylene or alkylene attached to the benzene ring through an oxygen or nitrogen atom in which said alkylene group may be substituted with amino, alkylamino or benzoyloxyamino, and said nitrogen atom may be substituted with acyl; and in which R 1 and R 2 are same or different, and represents hydrogen, lower alkyl, acyl, aminoalkyl or aminoacyloxyalkyl; in which R 3 represents lower alkyl, cyclo alkyl, benzyl, carbamoyl lower alkyl,-morpholinocarbonyl lower alkyl, pyrrolidinocarbonyl lower alkyl, piperidinocarbonyl lower alkyl, piperidino lower alkyl, anilinocarbonyl lower alkyl, alkylaminocarbonyl lower alkyl or alkoxycarbonyl lower alkyl; -OR 4 in which R 4 represents hydrogen, lower alkyl, aralkyl, succinimido, aminoacyloxyalkyl, aminoalkyloxyalkyl or aminoalkylcarbamoylalkyl; - N H-alkylene- in which R 5 represents lower alkyl, morpholine lower alkyl, morpholinocarbonyl lower alkyl, pyrrodinocarbonyl lower alkyl, piperidinocarbonyl lower alkyl or lower alkylaminocarbonyl lower alkyl; or in which Q represents straight-chain or branched-chain alkylene, R 6 and R 7 each represent lower alkyl, or both jointly form, together with an adjacent nitrogen atom, pyrrolidino, piperidino or morpholino.

Claim 4

The method according to claim 1 or claim 2, characterised in that said synthetic phenyl ester type chymotrypsin inhibitor is present in an amount of 0.1 to 10 mg based on one unit of said insulin.