Abstract An antiinflammatory cream preparation which comprises an antiinflammatory substance which is scarcely soluble in water in a base composition ast a concentration of from 0.05 to 1.5% by weight based on the preparation, the base composition comprising a medium chain fatty acid triglyceride, the fatty acid moiety of which contains from 6 to 12 carbon atoms, a carboxyvinyl polymer and purified water, preferably in a wright proportion of 1 - 25 : 0.3 - 3 : 75 - 99, and is adjusted to a pH of 4 to 10. The cream preparation provides good availability of the antiinflammatory substance contained therein and possesses low stimulation and high safety.
A cream preparation which comprises a pharmacologically active substance which.is scarcely soluble in water in a base composition comprising a medium chain fatty acid triglyceride the fatty acid moiety of which contains from 6 to 12 carbon atoms, a carboxyvinyl polymer and purified water, the pH of the cream preparation being within the range of from 4 to 10.
Claim 2
Dependent Claim
59 words
A cream preparation which comprises a pharmacologically active substance which.is scarcely soluble in water in a base composition comprising a medium chain fatty acid triglyceride the fatty acid moiety of which contains from 6 to 12 carbon atoms, a carboxyvinyl polymer and purified water, the pH of the cream preparation being within the range of from 4 to 10.
Claim 3
Dependent Claim
16 words
A cream preparation as claimed in Claim 1 wherein the active substance is an antiinflammatory substance.
Claim 4
Dependent Claim
14 words
A cream preparation as claimed in Claim 2 wherein the antiinflammatory substance is indomethacin.
Claim 5
Dependent Claim
14 words
A cream preparation as claimed in Claim 2 wherein the antiinflammatory substance is fluoromethalone.
Claim 6
Dependent Claim
33 words
A cream preparation as claimed in any one of the preceding claims wherein the active substance is contained therein at a concentration of from 0.05 to 1.5% by weight based on the preparation.
Claim 7
Dependent Claim
44 words
A cream preparation as claimed in any one of the preceding claims wherein the base composition contains the fatty acid triglyceride, the carboxyvinyl polymer and the purified water in the weight proportions of 1 - 25 : 0.3 - 3 : 75 - 99.
Claim 8
Dependent Claim
28 words
A cream preparation as claimed in any one of the preceding claims wherein the pH of the composition is adjusted by the addition of a pH controlling agent.
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