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EP0061217A2
Expired / Lapsed
EP
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Ibuprofen-containing sustained release pharmaceutical composition
Assignee: Pharmatec SpA
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Filing: 1982-03-03
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Granted: —
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Expires: 2002-03-03
Abstract
Abstract The invention relates to"an ibuprofen-containing sustained release pharmaceutical composition, comprising spheroids consisting of three components, namely a central core or microgranule of inert excipient, a layer of active principle applied on said central core, and an outer coating of active excipient forming the sustained release membrane. With this composition a remarkable reduction of the release rate is obtained in comparison with the known administration forms, reproducible results are obtained as release patterns of the active principle versus time and possible side effects are avoided.
Inventors
- 👤 Vittorio Dr. Giudice
- 👤 Vittorino Dr. Ravelli
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 05:27
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5073; A61K9/5078; A61K31/00; A61K31/185; A61K31/19
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
48 words
1) Ibuprofen-containing sustained release pharmaceutical composition characterized by the fact of comprising spheroids consisting of three components; namely a central core or microgranule of inert excipient, a layer of active principle applied on said central core, and an outer coating of active excipient forming the sustained release membrane.
Claim 2
Dependent Claim
48 words
1) Ibuprofen-containing sustained release pharmaceutical composition characterized by the fact of comprising spheroids consisting of three components; namely a central core or microgranule of inert excipient, a layer of active principle applied on said central core, and an outer coating of active excipient forming the sustained release membrane.
Claim 3
Dependent Claim
42 words
2) Ibuprofen-containing sustained release pharmaceutical composition according to Claim 1, characterized by the fact that the layer of active principle is applied on the inert microgranules by adding it as a powder with the aid of a solution of a suitable binder.
Claim 4
Dependent Claim
29 words
3) Ibuprofen-containing sustained release pharmaceutical composition according to Claim 1, characterized by the fact that the spheroids are spherical granules with a diameter of about 0.5 - 2 mm.
Claim 5
Dependent Claim
23 words
4) Ibuprofen-containing sustained release pharmaceutical composition according to Claim 1, characterized by the fact that the inert microgranules are sugar and starch cores.
Claim 6
Dependent Claim
28 words
5) Ibuprofen-containing sustained release pharmaceutical composition according to Claim 1, characterized by the fact that the composition of the inert microgranules is 80-90% sucrose and 10-20% corn starch.
Claim 7
Dependent Claim
21 words
6) Ibuprofen-containing sustained release pharmaceutical composition according to Claim 1, characterized by the fact of having an ibuprofen contents of 75-85%.
Claim 8
Dependent Claim
41 words
7) Ibuprofen-containing sustained release pharmaceutical composition according to Claim 2, characterized by the fact that the binder is a 15% solution of low viscosity polyvinylpyrrolidone in 95% ethyl alcohol, and the solvent is evaporated after application of the powdery active principle.
Claim 9
Dependent Claim
41 words
8) Ibuprofen-containing sustained release pharmaceutical composition according to Claim 1, characterized by the fact that the outer coating active excipient consists of high viscosity polyvinylpyrrolidone, which is applied as a 20% solution in 95% ethyl alcohol, the solvent being then evaporated.
Claim 10
Dependent Claim
28 words
9) Ibuprofen-containing sustained release pharmaceutical composition according to Claim 1, characterized by the fact that the spheroids are dosed in hard gelatine capsules as an oral administration form.
Claim 11
Dependent Claim
28 words
.10) Ibuprofen-containing sustained release pharmaceutical composition according to Claim 9, characterized by the fact that each hard gelatine capsule contains a dosage of 300 mg of active principle.
References Cited (Backward Citations)
No citation records indexed.
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