Patent EP0050480A2 successfully refreshed from Google Patents.
EP0050480A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Long lasting multi-layered film preparation and process for its production
Assignee: Ono Pharmaceutical Co Ltd
•
Filing: 1981-10-15
•
Granted: —
•
Expires: 2001-10-15
Abstract
Abstract The present invention provides multi-layered film preparations which comprise one or more water soluble polymer bases, one or more water insoluble polymer bases, one or more plasticizers and one or more prostaglandins, and optionally contain one or more organic acids, and they are composed of at least two drug release controlling layers (1) and one or more drug storing layers (2, 3). The multi-layered film preparations of the present invention are characterized by that the prostagiandin(s) containing therein exhibit the desired long-lasting release patterns at the concentration required for therapeutic purpose.
Inventors
- 👤 Inaba Kohji
- 👤 Sasatani Seiei
- 👤 Koide Tatsushi
- 👤 Nanya Tamio
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 07:47
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7092; A61K31/00; A61K31/557
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
41 words
A multi-layered film preparation which comprises (A) one or more water soluble polymer compounds, (B) one or more water insoluble polymer compounds, (C) one or more plasticizers and (D) one or more prostaglandins, and optionally contains one or more organic acids.
Claim 2
Dependent Claim
41 words
A multi-layered film preparation which comprises (A) one or more water soluble polymer compounds, (B) one or more water insoluble polymer compounds, (C) one or more plasticizers and (D) one or more prostaglandins, and optionally contains one or more organic acids.
Claim 3
Dependent Claim
23 words
A multi-layered film.,preparation according to claim 1 which comprises one or more drug storing layers and two or more drug release controlling layers.
Claim 4
Dependent Claim
18 words
A multi-layered film preparation according to claim 1 which contains prostaglandins in the drug storing layer or layers.
Claim 5
Dependent Claim
26 words
A multi-layered film preparation according to claim 1 which contains prostaglandins in the drug storing layer or layers and at least one drug release controlling layer.
Claim 6
Dependent Claim
36 words
A multi-layered film preparation according to claim 1 which has a drug storing layer or layers comprising one or more water soluble polymer compounds and one or more prostaglandins and optionally containing one or more plasticizers.
Claim 7
Dependent Claim
44 words
A multi-layered film preparation according to claim 1 which has a drug storing layer or layers comprising (A) one or more water soluble polymer compounds, (B) one or more water insoluble polymer compounds, (C) one or more plasticizers and (D) one or more prostaglandins.
Claim 8
Dependent Claim
37 words
A multi-layered film preparation according to claim 1 which has drug release controlling layers compriseing (A) one or more water soluble polymer compounds, (B) one or more water insoluble polymer compounds and (C) one or more plasticizers.
Claim 9
Dependent Claim
27 words
A multi-layered film preparation according to claim 1 which has a surface area of 1.5 - 30 cm 2 and a thickness of 0.1 - 3 mm.
Claim 10
Dependent Claim
23 words
A multi-layered film preparation according to claim 1 in which the water soluble polymer compound is hydroxypropyl cellulose, polyvinylpyrrolidone or hydroxypropyl methyl cellulose.
Claim 11
Dependent Claim
22 words
A multi-layered film preparation according to claim 1 in which the water insoluble polymer compound is cellulose acetate or vinyl acetate resin.
Claim 12
Dependent Claim
35 words
A multi-layered film preparation according to claim 1 in which the plasticizer is diethyl phthalate, butyl phthalyl butyl grycolate, glycerin, triacetin, tributyrin, polyethylene glycol, polypropylene grycol, propylene glycol, diethylene glycol, triethylene glycol or dipropylene glycol.
Claim 13
Dependent Claim
22 words
A multi-layered film preparation according to claim 1 in which the prostaglandin is prostaglandin F, prostaglandin E or 6,9-thio-prostaglandin I l .
Claim 14
Dependent Claim
19 words
A multi-layered film preparation according to claim 1 in which the organic acid is citric acid or tartaric acid.
Claim 15
Dependent Claim
24 words
A multi-layered film preparation according to claim 1 in which the water soluble polymer compound is contained at a proportion of 10 - 80%.
Claim 16
Dependent Claim
24 words
A multi-layered film preparation according to claim 1 in which the water insoluble polymer compound is contained at a proportion of 10 - 80%.
Claim 17
Dependent Claim
21 words
A multi-layered film preparation according to claim 1 in which the plasticizer is contained at a proportion of 10 - 30%.
Claim 18
Dependent Claim
22 words
A multi-layered film preparation according to claim 1 in which the organic acid is contained at a proportion of 0.01 - 0.5%.
Claim 19
Dependent Claim
39 words
A three-layered film preparation according to claim 1 which has two drug release controlling layers comprising vinyl acetate resin, glycerin, triacetin and hydroxypropyl cellulose, and therebetween one drug storing layer comprising hydroxypropyl cellulose, glycerin, triacetin, ONO-802 and tartaric anhydride.
Claim 20
Dependent Claim
46 words
A three-layered film preparation according to claim 1 which has two drug release controlling layers comprising cellulose acetate, butyl phthalyl butyl grycolate, triacetin and hydroxypropyl methyl cellulose, and therebetween one drug storing layer comprising hydroxypropyl methyl cellulose, butyl phthalyl butyl grycolate, triacetin, ONO-802 and tartaric anhydride.
Claim 21
Dependent Claim
37 words
A three-layered film preparation according to claim 1 which has two drug release controlling layers comprising vinyl acetate resin, glycerin, triacetin and polyvinylpyrrolidone, and therebetween one drug storing layer comprising polyvinylpyrrolidone, glycerin, triacetin, ONO-802 and tartaric anhydride.
Claim 22
Dependent Claim
79 words
A five-layered film preparation according to claim 1 which has the structure mounting successively (1) a drug release controlling layer comprising vinyl acetate resin, glycerin, triacetin and hydroxypropyl cellulose, (2) a drug storing layer comprising hydroxypropyl cellulose, glycerin, triacetin, ONO-802 and tartaric anhydride, (3) a drug storing layer comprising vinyl acetate resin, glycerin, triacetin, hydroxypropyl cellulose and 16,16-dimethyl-6,9-thio-PGI, methyl ester, (4) the drug storing layer as mentioned in (2),and (5) the drug release controlling layer as mentioned in (1).
Claim 23
Dependent Claim
78 words
A five-layered film preparation according to claim 1 which has the structure mounting successively (1) a drug release controlling layer comprising vinyl acetate resin, glycerin, triacetin and polyvinylpyrrolidone, (2) a drug storing layer comprising polyvinylpyrrolidone, glycerin, triacetin, ONO-802 and tartaric anhydride, (3) a drug storing layer comprising vinyl acetate resin, glycerin, triacetin, polyvinylpyrrodidone and 16,16-dimethyl-6,9-thio-PGI 1 methyl ester, (4) the drug storing layer as mentioned in (2), and (5) the drug release controlling layer as mentioned in (1).
Claim 24
Dependent Claim
42 words
A three-layered film preparation according to claim 1 which has two drug release controlling layers comprising vinyl acetate resin, glycerin, triacetin and hydroxypropyl cellulose, and therebetween one drug storing layer comprising vinyl acetate resin, glycerin, triacetin, hydroxypropyl cellulose, ONO-802 and tartaric anhydride.
Claim 25
Dependent Claim
115 words
A process for producing multi-layered film preparations which is characterized by using a laminating method to make a multi-layered film preparation from a film or films (drug storing layer or layers) obtained by dissolving water soluble polymer compound(s) and prostaglandin(s) in an organic solvent, further adding or not adding plasticizer(s) and/or organic acid(s) thereto, thoroughly stirring, and thereafter drying to remove the organic solvent by a conventional method and films (drug release controlling layers) obtained by dissolving water soluble polymer compound(s), water insoluble polymer compound(s) and plasticizer(s) in an organic solvent, further adding or not adding prostaglandin(s) and/or organic acid(s) thereto, thoroughly stirring, and thereafter drying to remove the organic solvent by a conventional method.
Claim 26
Dependent Claim
115 words
A process for producing multi-layered film preparations which is characterized by using a laminating method to make a multi-layered film preparation from a film or films (drug storing layer or layers) obtained by dissolving water soluble polymer compound(s) and prostaglandin(s) in an organic solvent, further adding or not adding plasticizer(s) and/or organic acid(s) thereto, thoroughly stirring, and thereafter drying to remove the organic solvent by a conventional method and films (drug release controlling layers) obtained by dissolving water soluble polymer compound(s), water insoluble polymer compound(s) and plasticizer(s) in an organic solvent, further adding or not adding prostaglandin(s) and/or organic acid(s) thereto, thoroughly stirring, and thereafter drying to remove the organic solvent by a conventional method.
Claim 27
Dependent Claim
118 words
A process for producing multi-layered film preparations which is characterized by using a laminating method to make a multi-layered film preparation from a film or films (drug storing layer or layers) obtained by dissolving water soluble polymer compound(s), water insoluble polymer compound(s), prostaglandin(s) and plasticizer(s) in an organic solvent, further adding or not adding organic acid(s) thereto, thoroughly stirring, and thereafter drying to remove the organic solvent by a conventional method and films (drug release controlling layers) obtained by dissolving water soluble polymer compound(s), water insoluble polymer compound(s) and plasticizer(s) in an organic solvent, further adding or not adding prostaglandin(s) and/or organic acid(s) thereto, thoroughly stirring, and thereafter drying to remove the organic solvent by a conventional method.
Claim 28
Dependent Claim
118 words
A process for producing multi-layered film preparations which is characterized by using a laminating method to make a multi-layered film preparation from a film or films (drug storing layer or layers) obtained by dissolving water soluble polymer compound(s), water insoluble polymer compound(s), prostaglandin(s) and plasticizer(s) in an organic solvent, further adding or not adding organic acid(s) thereto, thoroughly stirring, and thereafter drying to remove the organic solvent by a conventional method and films (drug release controlling layers) obtained by dissolving water soluble polymer compound(s), water insoluble polymer compound(s) and plasticizer(s) in an organic solvent, further adding or not adding prostaglandin(s) and/or organic acid(s) thereto, thoroughly stirring, and thereafter drying to remove the organic solvent by a conventional method.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.