Patent EP0046136A2 successfully refreshed from Google Patents.
EP0046136A2
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Membrane modified hydrogels, process for their manufacture and their use as active agent dispenser
Assignee: Novartis AG
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Filing: 1981-07-22
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Granted: —
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Expires: 2001-07-22
Abstract
Abstract Non-uniform water-insoluble interpenetrating polymer blend compositions comprising a first permeable water swellable polymer substrate interpenetrated in a gradient substantially normal to the substrate surface by a second less permeable condensation polymer to form a diffusion rate controlling membrane therein. Such compositions are useful as polymers with reduced permeabilities for water and organic solvents and therefore for the controlled delivery of active ingredients such as fragrances and bioaffecting agents into air or aqueous environments, or in membrane separation processes.
Inventors
- 👤 Karl Friedrich Mueller
- 👤 Sonia Jaworiw Heiber
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-27 18:28
CPC Classifications
C; C08; C08L; C08L75/00; C08L75/04; A; A01; A01N; A01N25/00; A01N25/08; A01N25/10; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2027; A61L; A61L9/00; A61L9/015; A61L9/04; A61L9/042; A61L9/12; B; B01; B01D; B01D69/00; B01D69/14; B01D69/141; C08G; C08G18/00; C08G18/06; C08G18/08; C08J; C08J3/00; C08J3/005; C08L101/00; C08L75/14; C08L75/16; C08G2210/00; C08G2270/00; C08L2205/00; C08L2205/04; Y; Y10; Y10S; Y10S424/00; Y10S424/07; Y10S525/00; Y10S525/903; Y10S525/905; Y10T; Y10T428/00; Y10T428/13; Y10T428/1334; Y10T428/1341; Y10T428/1352; Y10T428/1379; Y10T428/24; Y10T428/24942; Y10T428/24992; Y10T428/249921; Y10T428/249953; Y10T428/249955; Y10T428/249961; Y10T428/249994; Y10T428/249995; Y10T428/249997; Y10T428/249999; Y10T428/29; Y10T428/2913; Y10T428/2973; Y10T428/2975; Y10T428/2982; Y10T428/2991; Y10T428/2998; Y10T428/31
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
40 words
A non-uniform substantially water-insoluble interpenetrating polymer blend composition comprising a water swellable first polymer substrate interpenetrated in a gradient substantially normal to the substrate surface by a less permeable condensation second polymer to form a diffusion rate controlling membrane therein.
Claim 2
Dependent Claim
40 words
A non-uniform substantially water-insoluble interpenetrating polymer blend composition comprising a water swellable first polymer substrate interpenetrated in a gradient substantially normal to the substrate surface by a less permeable condensation second polymer to form a diffusion rate controlling membrane therein.
Claim 3
Dependent Claim
121 words
A composition according to claim 1, wherein said water swellable first polymer (hydrogel) is a crosslinked homo- or copolymer containing units of hydroxylakyl esters of amides of (meth)acrylic acid or their ethoxylated derivatives; hydroxyalkyl mono- or diesters of maleic (fumaric) acid, or their ethoxylated derivatives; hydroxyalkylvinyl ethers, N-vinyl-pyrrolidone, N-vinyl-pyrrolidine, 4- and 2-vinylpyridine, N,N-dialkylamino alkyl esters or amides of (meth)acrylic acid, (meth)acrylic acid, (meth)acrylamide, sodium styrene sulfonate, sodium vinyl sulfonate or vinyl alcohol; or is a polyethylene oxide containing polycondensate, a copolymer of an unsaturated polyester based on maleic anhydride and alkylene diols with water soluble comonomers, a cellulosic material or a protein, with the proviso that the hydrogel is swellable to an extent of at least 5% by weight in water.
Claim 4
Dependent Claim
77 words
A composition according to claim 2, wherein said water swellable first polymer is (modified) cellulose, or a homopolymer or copolymer containing units of vinyl alcohol, acrylamide, hydroxyalkyl-CC 2 -C 4 )-acrylate or -methacrylate, vinylpyrrolidone, or hydroxyalkyl-(C 2 -C 4 )-vinyl ether, hydroxyalkyl maleate or -fumarate or a polyethyleneoxide diol containing polycondensate, with proviso that sufficient said units are incorporated such that said first polymer is swellable to an extent of at least 5% by weight in water.
Claim 5
Dependent Claim
34 words
A composition according to claim 3, wherein the hydrogel is a crosslinked homopolymer containing units of hydroxyalkyl(C 2 -C 4 ) acrylates, -methacrylates, or vinylpyrrolidone or a copolymer containing units of said monomer mixtures.
Claim 6
Dependent Claim
57 words
A composition according to claim 4, wherein the crosslinking agent is a macromer being a reaction product of a polylakylene ether glycol, preferably polybutylene glycol with a molecular weight-between about 600 and about 4000, first terminated with tolylene-2,4-diisocyanate or isophorone diisocyanate and then endcapped with a hydroxyalkyl(meth)-acrylate with 2 to 4 carbon atoms in the alkyl moiety.
Claim 7
Dependent Claim
39 words
A composition according to claim 3, wherein said water swellable first polymer (hydrogel) is cellulose, polyvinyl alcohol, or a copolymer of hydroxyethyl-methacrylate, N-vinylpyrrolidone and optionally a C l -C 18 alkylacrylate or -methacrylate comonomercrosslinked with isophoronediisocyanate capped polytetramethylene oxide.
Claim 8
Dependent Claim
32 words
A composition according to anyone of claims 1 to 6, wherein the hydrogel which is in the form of a bead having an average diameter between about 0.05 mm and 4 mm.
Claim 9
Dependent Claim
25 words
A composition according to claim 1, wherein said less permeable condensation second polymer is an aliphatic or aromatic polyurethane, polyester, polyamide, polyimide, polyurea or polyimine.
Claim 10
Dependent Claim
26 words
A composition according to claim 8, wherein said less permeable condensation second polymer is an aliphatic or aromatic polyurethane, an aliphatic polyurea or an aliphatic polyester.
Claim 11
Dependent Claim
41 words
A composition according to claim 9, wherein the polyurethanes or polyesters are obtainable by reacting (A) an aliphatic, optionally halogen containing, diol of 2 to 6 carbon atoms with (B) 2,2,4(2,4,4)-trimethylbexane-1,6-diisocyanate, tulylene-2,4-diisocyanate, isophorone diisocyanate or 4,4'-diisocyanatodiphenylmethane, maleic anhydride or sebacoyl chloride..
Claim 12
Dependent Claim
42 words
A composition according to claim 9, wherein the polyureas are obtainable by reacting (A) 2,2,4(2,4,4)-trimethylhexane-l,6-diisocyanate, tulylene-2,4-diisocyanate, isophorone diisocyanate or 4,4'-diisocyanatodiphenylmethane with poly-primary amines or by reacting said diisocyanates with water to from primary amino groupswhich in turn react with the isocyanate groups.
Claim 13
Dependent Claim
17 words
A composition according to claim 1, which is in the form of a sheet, tube or pouch.
Claim 14
Dependent Claim
23 words
A composition according to claim 12, wherein the sheet, tube or pouch has a wall thickness between about 0.01 mm and 5 mm.
Claim 15
Dependent Claim
19 words
A composition according to claim 13, wherein the composition is a tube in the form of a hollow fiber.
Claim 16
Dependent Claim
28 words
A composition according to claim 7, wherein there is contained within said head an active ingredient selected from the group consisting of a drug, herbicide, insecticide or fragrance.
Claim 17
Dependent Claim
52 words
A process for preparing a water-insoluble interpenetrating polymer blend composition according to claim 1, which comprises loading the first polymer (hydrogel) with reactant (A) and reacting it with coreactant (B) in order to form a second less permeable condensation polymer being an aliphatic or aromatic polyurethane, polyester, polyamide, polyimide, polyurea or polyimine.
Claim 18
Dependent Claim
32 words
A process according to claim 16, wherein components (A) and (B) are polyhydric alcohols, aliphatic or aromatic diisocyanates, di-acid chlorides, dialdehydes, anhydrides, poly-primary and poly-secondary aliphatic amines, amino alcohols or aromatic polyamines.
Claim 19
Dependent Claim
67 words
A process according to claim 17, wherein component (A) is an aliphatic diol of up to 10 carbon atoms, or a diacid chloride of the formula CLOC(CH 2 ) k COC1, wherein k is 0 to 18 and component (B) is an aliphatic or aromatic diisocyanate, an aliphatic anhydride or a poly-primary aliphatic amine, with the proviso that aliphatic or aromatic polyurethanes, polyesters or polyamides are formed.
Claim 20
Dependent Claim
51 words
A process according to claim 18, wherein component (A) is an aliphatic, optionally halogen containing, diol of 2 to 6 carbon atoms, and component (B) is 2,2,4(2,4,4)-trimethylhexane-1,6-diisocyanate, tulylene-2,4-diisocyanate, isophorone diisocyanate or 4,4'-diiso- cyanatodiphenyimethane, maleic anhydride or sebacoyl chloride, with the proviso that aliphatic or aromatic polyurethanes or aliphatic esters are formed.
Claim 21
Dependent Claim
42 words
A process according to claim 17 for preparing polyureas, wherein component (A) is an aliphatic or aromatic diisocyanate and component (B) is a poly-primary amine, optionally obtained from said diisocyanate by reaction with water forming amino groups that react with said diisocyanates.
Claim 22
Dependent Claim
16 words
A process according to claim 20, wherein component (A) is 2,2,4(2,4,4)-trimethylhexane-1,6-diisocyanate, tulylene-2,4-diisocyanate, isophorone diisocyanate or 4,4'-diisocyanatodiphenylmethane.
Claim 23
Dependent Claim
91 words
22 . A process according to anyone of claims 16 to 21, wherein the first polymer (hydrogel) is a homopolymer containing units of hydroxyalkyl (C 2 -C 4 )acrylates, -methacrylates or vinylpyrrolidone or a copolymer containing units of said monomeric mixtures, crosslinked with a macromer, being a reaction product of a polyalkylene ether glycol, preferably polybutylene glycol with a molecular weight between about 600 and about 4000, first terminated with tolylene-2,4-diisocyanate or isophorone diisocyanate and then endcapped with a hydroxylalkyl (meth)acrylate with 2 to 4 carbon atoms in the alkyl moiety.
Claim 24
Dependent Claim
16 words
Use of the composition according to anyone of claims 1 to 15 as active agent dispenser.
Claim 25
Dependent Claim
76 words
A water actuated diffusion type active agent dispenser including a means for dispensing a dosage of active agent into an aqueous fluid environment, comprising a bead of a substantially water insoluble polymer blend composition according to claim 1 containing a diffusion rate controlling membrane parallel to the surface of said bead, said membrane form an inclosure for said active agent to continuously dispense said agent at a controlled and continuous rate by diffusion across the membrane.
Claim 26
Dependent Claim
17 words
A dispenser according to claim 24, wherein at least part of said active agent is a drug.
References Cited (Backward Citations)
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