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EP0045647A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

A method of forming a stable chromophore derived from vanylmandelic acid and the use thereof in the determination of vanylmandelic acid

Assignee: Tierney Thomas Thaddeus
•
Filing: 1981-07-31
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Granted: —
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Expires: 2001-07-31
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Abstract

Abstract The invention provides a method of forming a stable chromophore derived from vanylmandelic acid characterised by forming an ethyl acetate extract of a diazo derivative of vanylmandelic acid and adding dimethyl-sulphoxide and 2-amino-2-methyl-1-propanol to said extract. The diazo derivative may be the reaction product of p-nitrobenzenediazonium salt and vanylmandelic acid. The invention also includes a method of determining vanylmandelic acid characterised by forming a stable chromophore by the above method and quantitatively determining said stable chromophore. The method is particularly useful for the determining of urinary vanylmandelic acid.

Inventors

  • 👤 Mohamed Zouheir Mahmoud Habbal

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-24 02:48
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; Y; Y10; Y10T; Y10T436/00; Y10T436/20; Y10T436/200833; Y10T436/201666

Claims Analysis

Total Claims: 7
Claim 1
Independent Claim 33 words
A method of forming a stable chromophore derived from vanylamandelic acid characterised by forming an ethyl acetate extract of a diazo derivative of vanylmandelic acid and adding dimethylsulphoxide and 2-amino-2-methyl-1-propanol to said extract.
Claim 2
Independent Claim 33 words
A method of forming a stable chromophore derived from vanylamandelic acid characterised by forming an ethyl acetate extract of a diazo derivative of vanylmandelic acid and adding dimethylsulphoxide and 2-amino-2-methyl-1-propanol to said extract.
Claim 3
Dependent Claim 23 words
A method as claimed in claim 1 characterised in that the diazo derivative is the reaction product of p-nitrobenzenediazonium salt and vanylmandelic acid.
Claim 4
Independent Claim 46 words
A method as claimed in claim.1 or 2 charaet- ierised in that from about 0.1 to about 0.9 parts by volume of dimethylsulphoxide and from about 0.01 to about 0.5 parts by volume of 2-amino-2-methyl-1-propanol are added to each 2 parts by volume of said extract.
Claim 5
Dependent Claim 32 words
A method as claimed in claim 3 characterised in that from about 0.01. to about 0.1 parts by volume of 2-amino-2-methyl-1-propanol are added to each 2 parts by volume of said extract.
Claim 6
Independent Claim 31 words
A method for the determination of vanylmandelic acid characterised by forming a stable chromophore by the method claimed in any of claims 1 to 4 and quantitatively determining said stable chromophore.
Claim 7
Dependent Claim 16 words
A method as claimed in claim 5 characterised in that said stable chromophore is determined spectrophotometrically.

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