Patent EP0043738B1 successfully refreshed from Google Patents.
EP0043738B1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Penetrating topical pharmaceutical compositions
Assignee: Procter and Gamble Co
•
Filing: 1981-07-09
•
Granted: 1985-10-02
•
Expires: 2001-07-09
Abstract
No abstract record available.
Inventors
- 👤 Richard Randall Wickett
- 👤 Eugene Rex Cooper
- 👤 Maurice Edward Loomans
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 20:46
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/06; A61K47/08; A61K47/14; A61K47/10; A61K9/00; A61K9/0012; A61K9/0014; A61P; A61P17/00; A61P29/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
121 words
a composition for topical administration which includes: (a) from 0.01% to 35% by weight of a pharmacological active selected from nonsteroidal anti-inflammatory agents, local anesthetics, antibiotic agents, and benzoyl peroxide; (b) from 0 to 70% by weight of ethanol or 2-propanol; and (c) from 0.01% to 99% by weight of a penetration-enhancing carrier; characterized in that the penetration-enhancing carrier consists essentially of (i) a diol compound selected from 1,2-ethanediol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, 2-ethoxyethanol, 2,2'-oxy-bis-ethanol and glycerol monoacetate; and (ii) a cell envelope-disordering compound selected from methyl myristate, methyl laurate, ethyl laurate, ethyl myristate, myristyl acetate, lauryl acetate and mixtures thereof; the ratio of cell envelope-disordering compound:diol compound being in the range of from 1:1 to 1:500 by weight.
Claim 2
Dependent Claim
121 words
a composition for topical administration which includes: (a) from 0.01% to 35% by weight of a pharmacological active selected from nonsteroidal anti-inflammatory agents, local anesthetics, antibiotic agents, and benzoyl peroxide; (b) from 0 to 70% by weight of ethanol or 2-propanol; and (c) from 0.01% to 99% by weight of a penetration-enhancing carrier; characterized in that the penetration-enhancing carrier consists essentially of (i) a diol compound selected from 1,2-ethanediol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, 2-ethoxyethanol, 2,2'-oxy-bis-ethanol and glycerol monoacetate; and (ii) a cell envelope-disordering compound selected from methyl myristate, methyl laurate, ethyl laurate, ethyl myristate, myristyl acetate, lauryl acetate and mixtures thereof; the ratio of cell envelope-disordering compound:diol compound being in the range of from 1:1 to 1:500 by weight.
Claim 3
Dependent Claim
16 words
A composition according to Claim 1 characterized in the pharmacological active is a nonsteroidal anti-inflammatory agent.
Claim 4
Dependent Claim
33 words
A composition according to Claim 2 characterized in that the nonsteroidal anti-inflammatory agent is selected from salicyclic acid, ibuprofen, sulindac, naproxen, ketoprofen, ethofenamate, and indomethacin and the pharmaceutically acceptable salts and esters thereof.
Claim 5
Dependent Claim
25 words
A composition according to Claim 3 characterized in that the nonsteroidal anti-inflammatory agent is selected from indomethacin, the methyl ester of indomethacin, and mixtures thereof.
Claim 6
Dependent Claim
23 words
A composition according to any one of Claims 1-4 characterized in that the diol compound is selected from 1,2-propanediol, 2,2'-oxy-bis-ethanol and mixtures thereof.
Claim 7
Dependent Claim
27 words
A composition according to any one of Claims 1-5 characterized in that the cell- envelope disordering compound is selected from methyl myristate, methyl laurate and mixtures thereof.
Claim 8
Dependent Claim
23 words
A composition according to any one of Claims 1-6 characterized in that the cell envelope-disordering compound:diol compound ratio is from 1:10 to 1:100.
Claim 9
Dependent Claim
34 words
A composition according to any one of Claims 1 or 5-7 characterized in that the pharmacological active is an antibiotic agent selected from erythromycin, penicillin, tetracycline, chloramphenicol and the pharmaceutically-acceptable salts and esters thereof.
Claim 10
Dependent Claim
20 words
A composition according to any one of Claims 1 or 5-7 characterized in that the pharmacological active is benzoyl peroxide.
Claim 11
Dependent Claim
36 words
A composition according to any one of Claims 1 to 5-7 characterized in that the pharmacological active is a local anesthetic selected from lidocaine, procaine, mepivacaine, bupivacaine, dibucaine, tetracaine and the pharmaceutically-acceptable salts and esters thereof.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.