A non-toxic anthelminthic pour-on composition

Claim 2

A pour-on composition for combating helminthic infestations in a non-human animal, comprising: a. an anthelminthically effective amount of dℓ-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]-thiazole and/or the laevo isomer thereof; b. one or more optionally substituted aliphatic carboxylic acids, having each a pKa-value comprised between 3 and 6, the molar ratio of the total amount of said carboxylic acids to the total amount of the anthelminthics varying between 0.01 and 3; and c. an amount, varying from 10 to 70% by volume, of at least one di(lower alkyl) dicarboxylic acid ester of the formula wherein X represents a direct bond or an alkylene radical having from 1 to 12 carbon atoms.

Claim 3

A pour-on composition according to Claim 1, containing additionally from 1 to 30% of a dipolar aprotic solvent.

Claim 4

A pour-on composition according to Claim 1 or Claim 2, containing additionally from 10 to 60% of an aliphatic hydrocarbon fraction.

Claim 5

A pour-on composition for combating helminthic infestations in a non-human animal comprising: a, an anthelminthically effective amount of dℓ-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]-thiazole and/or the laevo isomer thereof; b. one or more optionally substituted aliphatic carboxylic acids, having each a pKa-value comprised between 3 and 6, the molar ratio of the total amount of said carboxylic acids to the total amount of the anthelminthics varying between 0.01 and 3; c. an amount, varying from 10 to 70% by volume, of at least one di(lower alkyl) dicarboxylic acid ester of the formula wherein X represents a direct bond or an alkylene radical having from 1 to 12 carbon atoms; d. an amount, varying from 5 to 15% of N-methyl-2-pyrrolidone; and e. an amount, varying from 10 to 60% of an optionally substituted aliphatic hydrocarbon fraction, having a boiling range comprised between 170°C and 230°C.

Claim 6

A pour-on composition for combating helminthic infestations in a non-human animal comprising: a, an anthelminthically effective amount of dℓ-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]-thiazole and/or the laevo isomer thereof; b. one or more optionally substituted aliphatic carboxylic acids, having each a pKa-value comprised between 3 and 6, the molar ratio of the total amount of said carboxylic acids to the total amount of the anthelminthics varying between 0.01 and 3; c. an amount, varying from 10 to 70% by volume, of at least one di(lower alkyl) dicarboxylic acid ester of the formula wherein X represents a direct bond or an alkylene radical having from 1 to 12 carbon atoms; d. an amount, varying from 5 to 15% of N-methyl-2-pyrrolidone; and e. an amount, varying from 10 to 60% of an optionally substituted aliphatic hydrocarbon fraction, having a boiling range comprised between 170°C and 230°C.

Claim 7

A pour-on composition according to Claim 4, comprising additionally from 0 to 15% of a co-solvent.

Claim 8

A pour-on composition according to Claim 4 or Claim 5, wherein the ratio of the total amount of optionally subtituted aliphatic carboxylic acids to the total amount of the anthelminthics varies between 0.05 and 1.

Claim 9

A pour-on composition according to any one of Claims 4 to 6, wherein the optionally substituted aliphatic carboxylic acids have pKa-values comprised between 4 and 5.5.

Claim 10

A pour-on composition according to any one of Claims 1 to 7, wherein the anthelminthic is ℓ-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]-thiazole.

Claim 11

A pour-on composition for combating helminthic infestations in a non-human animal comprising: a. from 5 to 20g A-2,3,5,6-tetrahydro-6- phenylimidazo[2,1-b]-thiazole per 100 ml of the resulting composition; b. acetic acid, the molar ratio of the amount of acetic acid to the amount of ℓ-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]-thiazole varying between 0.05 and 1; c. an amount, varying from 25 to 60% by volume, of di(l-propyl)-adipic acid ester and/or di(2-propyl)adipic acid ester; d. an amount, varying from 5 to 15%, of N-methyl-2-pyrrolidone; e. an amount, varying from 10 to 60%, of an optionally substituted aliphatic hydrocarbon fraction, having a boiling range comprised between 170°C and 230°C; and f. an amount, varying from 0 to 5% of 2-propanol.

Claim 12

A pour-on composition for combating helminthic infestations in a non-human animal comprising: a. from 5 to 20g A-2,3,5,6-tetrahydro-6- phenylimidazo[2,1-b]-thiazole per 100 ml of the resulting composition; b. acetic acid, the molar ratio of the amount of acetic acid to the amount of ℓ-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]-thiazole varying between 0.05 and 1; c. an amount, varying from 25 to 60% by volume, of di(l-propyl)-adipic acid ester and/or di(2-propyl)adipic acid ester; d. an amount, varying from 5 to 15%, of N-methyl-2-pyrrolidone; e. an amount, varying from 10 to 60%, of an optionally substituted aliphatic hydrocarbon fraction, having a boiling range comprised between 170°C and 230°C; and f. an amount, varying from 0 to 5% of 2-propanol.

Claim 13

A pour-on composition in accordance with any one of Claims 1 to 9 for use as an anthelminthic agent.