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EP0031999A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Antitumor protein hybrid and process for the preparation thereof

Assignee: Teijin Ltd
•
Filing: 1980-12-03
•
Granted: —
•
Expires: 2000-12-03
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Abstract

Abstract Antitumor protein hybrid, having a moiety consisting of the antitumor immunoglobulin and a moiety substantially consisting of the fragment A of a diphtheria toxin, which is expressed by the following formula (I): (where Ab indicates a moiety consisting of the antitumor immunoglobulin and FA indicates a moiety substantially consisting of the fragment A of a diphtheria toxin; X is an alkylene group or phenylene group which either has or does not have a branching of 1 to 5 carbon atoms. N in the amido bond is a nitrogen atom arising from the amino group in the antitumor immunoglobulin; S 1 and S 2 are both sulfur atoms, S 2 indicating a sulfur atom arising from the disulfide bond in a diphtheria toxin; n stands for an integer of 1 to 5). This antitumor protein hybrid has remarkable and specific citotoxicity against tumor cells.

Inventors

  • 👤 Yasuhiko Masuho
  • 👤 Naoji Umemoto
  • 👤 Takeshi Hara
  • 👤 Hidematsu Hirai

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-23 23:07
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/28; C07K16/30; C07K16/303; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61K47/6801; A61K47/6803; A61K47/6811; A61K47/6817; A61K47/6829; A61K47/6835; A61K47/6881; A61P; A61P35/00; C07K2319/00; C07K2319/55

Claims Analysis

Total Claims: 5
Claim 1
Independent Claim 130 words
Antitumor protein hybrid, having a moiety consisting of the antitumor immunoglobulin and a moiety substantially consisting of the fragment A of a diphtheria toxin, which is expressed by the following formula (I): (where Ab indicates a moiety consisting of the antitumor immunoglobulin and FA indicates a moiety substantially consisting of the fragment A of a diphtheria toxin; X is an alkylene group or phenylene group which either has or does not have a branching of 1 to 5 carbon atoms; N in the amido bond is a nitrogen atom arising from the amino group in the antitumor immunoglobulin; S1 and S 2 are both sulfur atoms, S 2 indicating a sulfur atom arising from the disulfide bond in a diphtheria toxin; n stands for an integer of 1 to 5).
Claim 2
Dependent Claim 130 words
Antitumor protein hybrid, having a moiety consisting of the antitumor immunoglobulin and a moiety substantially consisting of the fragment A of a diphtheria toxin, which is expressed by the following formula (I): (where Ab indicates a moiety consisting of the antitumor immunoglobulin and FA indicates a moiety substantially consisting of the fragment A of a diphtheria toxin; X is an alkylene group or phenylene group which either has or does not have a branching of 1 to 5 carbon atoms; N in the amido bond is a nitrogen atom arising from the amino group in the antitumor immunoglobulin; S1 and S 2 are both sulfur atoms, S 2 indicating a sulfur atom arising from the disulfide bond in a diphtheria toxin; n stands for an integer of 1 to 5).
Claim 3
Dependent Claim 13 words
Antitumor protein hybrid according to Claim 1, wherein X is an ethylene group.
Claim 4
Dependent Claim 21 words
Antitumor protein hybrid according to Claim 1, wherein FA is a moiety consisting of the fragment A of a diphtheria toxin.
Claim 5
Dependent Claim 128 words
A process for the preparation of antitumor protein hybrid expressed by the following formula (I), (where definitions of Ab, FA, X, N, S 1 , S 2 , and n are as same as those given in case of Claim 1), which comprises the reaction of 1 to 5 amino groups of the antitumor immunoglobulin with a compound which is expressed by the following formula (II), (where X is an alkylene group or phenylene group which either has or does not have a branching of 1 to 5 carbon atoms. Y indicates Both S 1 and S 0 indicate a sulfur atom,) and the reaction of thus obtained product with the substantial fragment A of a diphtheria toxin which has at least one thiol group in the fragment.

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