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EP0026618A1
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Process for the preparation of an acylation product from a mixture of chitin derivatives
Assignee: Kureha Corp
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Filing: 1980-09-18
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Granted: —
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Expires: 2000-09-18
Abstract
Abstract A material has at least its surface layer formed of the product obtained by acylation of a mixture of two or more chitin derivatives selected from compounds represented by theformula (1): wherein R represents a carboxyalkyl group of from two to four carbon atoms, a hydroxyethyl group, a hydroxypropyl group, a dihydroxypropyl group or an alkyl group of from one to three carbon atoms, is a number of 0.1 to 1.0, y = 1.0-x,a isa number of 0 to 1.0, and b = 1.0-a, and salts of said compounds of formula (1). Such a material can be prepared in the form of spherical particles, fibers or films. The material can be employed as an ion-exchanger, in blood perfusion, as an orally administrable adsorbent, as a coating material for adsorbents, as a filler for chromatographic columns, as a base material on which an enzyme, antibody or antigen is to be immobilised, or in the formation of a polyion with an anti-thrombogenicsubstance.
Inventors
- 👤 Junichi Koshugi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-03 12:30
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0024; C08B37/0027; C08B37/003
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
121 words
A material at least the surface layer of which comprises the product obtained by acylation of a mixture of two or more chitin derivatives selected from compounds represented by the formula (1): [C 6 H 8 O 3 .(NH 2 ) X .(NHCOCH 3 ) y .(OR) a .(OH) b ] n (1) wherein R represents a carboxyalkyl group of from two to four carbon atoms, a hydroxyethyl group, a hydroxypropyl group, a dihydroxypropyl group or an alkyl group of from one to three carbon atoms, x is a number of 0.1 to 1.0, y = 1.0 - x, a is a number of 0 to 1.0, and b = 1.0 - a, and salts of said compounds of formula (1).
Claim 2
Dependent Claim
121 words
A material at least the surface layer of which comprises the product obtained by acylation of a mixture of two or more chitin derivatives selected from compounds represented by the formula (1): [C 6 H 8 O 3 .(NH 2 ) X .(NHCOCH 3 ) y .(OR) a .(OH) b ] n (1) wherein R represents a carboxyalkyl group of from two to four carbon atoms, a hydroxyethyl group, a hydroxypropyl group, a dihydroxypropyl group or an alkyl group of from one to three carbon atoms, x is a number of 0.1 to 1.0, y = 1.0 - x, a is a number of 0 to 1.0, and b = 1.0 - a, and salts of said compounds of formula (1).
Claim 3
Dependent Claim
73 words
A material according to claim 1, wherein x is from 0.2 to 0.6 when R in the formula (1) represents a carboxyalkyl group of from two to four carbon atoms, a hydroxyethyl group, a hydroxypropyl group or a dihydroxypropyl group; and x is from 0.5 to 0.9 when R in the formula (1) represents an alkyl group of from one to three carbon atoms or when a in the formula (1) is 0.
Claim 4
Dependent Claim
27 words
A material according to claim 1 or 2 wherein a in the formula (1) is from 0.3 to 1.0 when the chitin derivative is de-N-acetylated and etherified.
Claim 5
Dependent Claim
61 words
A material according to any one of the preceding claims, wherein said mixture contains (A) at least one chitin derivative selected from the de-N-acetylated chitin and the de-N-acetylated alkyl chitin formula (1) and (B) at least one chitin derivative selected from the de-N-acetylated carboxyalkyl chitin, the de-N-acetylated hydroxyethyl chitin, the de-N-acetylated hydroxypropyl chitin and the de-N-acetylated dihydroxypropyl chitin of formula (1).
Claim 6
Dependent Claim
25 words
A material according to claim 4, wherein the mixture contains from 0.05 to 50 parts by weight of (B) per part by weight of (A).
Claim 7
Dependent Claim
16 words
A material according to any one of the preceding claims wherein the acylated product is cross-linked.
Claim 8
Dependent Claim
22 words
A material according to any one of the preceding claims which is shaped in the form of a sphere, fiber or film.
Claim 9
Dependent Claim
44 words
A material according to any one of the preceding claims comprising two or more layers, each layer comprising a product obtained by acylation as defined in claim 1, the acylated product of one layer being different from the acylated product of an adjacent layer.
Claim 10
Dependent Claim
40 words
A material comprising an acylated product of the chitin derivative having a faster reaction velocity of acylation with an acylating agent and another acylated product of the chitin derivative having a slower reaction velocity of acylation with another acylating agent.
Claim 11
Dependent Claim
40 words
A material comprising an acylated product of the chitin derivative having a faster reaction velocity of acylation with an acylating agent and another acylated product of the chitin derivative having a slower reaction velocity of acylation with another acylating agent.
Claim 12
Dependent Claim
89 words
A process for the preparation of a material as claimed in any one of claims 1 to 8, which process comprises contacting a mixture of two or more chitin derivatives selected from compounds of the formula (1) and salts of said compounds of formula (1) with a first acylating agent to at least partially acylate the chitin derivative which has the faster acylation reaction velocity, and contacting the thus produced material with another acylating agent to at least partially acylate the chitin derivative(s) having the slower acylation reaction velocity.
Claim 13
Dependent Claim
76 words
Use of a material as claimed in any one of claims 1 to 9 or which has been prepared by a process as claimed in claim 10 as an ion-exchanger, in blood perfusion, as an orally administerable adsorbent, as a coating material for adsorbents, as a filler for chromatographic columns, as a base material on which an enzyme, antibody or antigen is to be immobilised, or in the formation of a polyion with an anti-thrombogenic substance.
References Cited (Backward Citations)
DE894993C
Cited
EP0013181A2
Cited
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