Patent EP0021766A2 successfully refreshed from Google Patents.
EP0021766A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Inhibitors of mammalian collagenase
Assignee: ER Squibb and Sons LLC
•
Filing: 1980-06-16
•
Granted: —
•
Expires: 2000-06-16
Abstract
Abstract Mammalian collagenase is inhing the formulaand salts thereof, whereinR<sub>1</sub> is hydrogen or alkanoyl of 2 to 10 carbon atoms;R<sub>2</sub> is hydroxy, amino, orR<sub>3</sub> is hydrogen, alkyl of 1 to 4 carbon atoms,orR<sub>4</sub> is hydroxy, amino, arginine, leucine, glutamine, alanine or glycine; andm is 0 or an integer of 1 to 9.
Inventors
- 👤 Joseph E. Sundeen
- 👤 Tamara Dejneka
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-04 12:09
CPC Classifications
C; C07; C07C; C07C51/00; C07C51/347; C07C51/377; A; A61; A61P; A61P43/00; C07C323/00; C07C327/00; C07C51/08; C07C51/367; C07C51/58; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06008; C07K5/06017; C07K5/06026; A61K; A61K38/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
61 words
A compound having the formula or a salt thereof wherein R 1 is hydrogen or alkanoyl of 2 to 10 carbon atoms; R 2 is hydroxy, amino or R 3 is hydrogen, alkyl of 1 to 4 carbon atoms, R 4 is hydroxy, amino, arginine, leucine, glutamine, alanine or glycine; and m is 0 or an integer from 1 to 9.
Claim 2
Dependent Claim
61 words
A compound having the formula or a salt thereof wherein R 1 is hydrogen or alkanoyl of 2 to 10 carbon atoms; R 2 is hydroxy, amino or R 3 is hydrogen, alkyl of 1 to 4 carbon atoms, R 4 is hydroxy, amino, arginine, leucine, glutamine, alanine or glycine; and m is 0 or an integer from 1 to 9.
Claim 3
Dependent Claim
11 words
The compound in accordance with Claim 1, 2-(mercaptomethyl)-4-methylpentanoic acid, ammonium salt.
Claim 4
Dependent Claim
8 words
The compound in accordance with Claim 1, 2-(mercaptomethyl)-4-methylpentanamide.
Claim 5
Dependent Claim
8 words
The compound in accordance with Claim 1, N-[2-(mercaptomethyl)-4-methyl-l-oxopentyl]glycine.
Claim 6
Dependent Claim
8 words
The compound in accordance with Claim 1, N-[6-[2-[(acetylthio)methyl]-4-methyl-1-oxopentyl]-l-oxohexyl]-L-arginine.
Claim 7
Dependent Claim
9 words
The compound in accordance with Claim 1, N-[6-[[2-(mercaptomethyl)-4-methyl-l-oxopentyl]amino- l-oxohexyl]-L-arginine.
Claim 8
Dependent Claim
9 words
The compound in accordance with Claim 1, 6-[[2-(acetylthio)methyl]-4-methyl-1-oxopentyl] amino]hexanamide.
Claim 9
Dependent Claim
8 words
The compound in accordance with Claim 1, N-[N-[2-(mercaptomethyl)-4-methyl-l-oxopentyl]glycyl]-L-arginine.
Claim 10
Dependent Claim
9 words
The compound in accordance with Claim 1, N-[5-[[2-(mercaptomethyl)-4-methyl-1-oxopentyl] amino-1-oxopentyl]-L-arginine.
Claim 11
Dependent Claim
9 words
The compound in accordance with Claim 1, N-[8-[[2-mercaptomethyl)-4-methyl-1-oxopentyl] amino-1-oxooctyl]-L-arginine.
Claim 12
Dependent Claim
22 words
A compound in accordance with any preceding claim for use in reducing the adverse effects of mammalian collagenase in a mammalian host.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.