Patent EP0013263A2 successfully refreshed from Google Patents.
EP0013263A2
Expired / Lapsed
EP
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A pharmaceutical preparation comprising a cardiac glycoside in combination with a polymer, and a process for preparation thereof
Assignee: Hassle AB
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Filing: 1979-12-13
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Granted: —
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Expires: 1999-12-13
Abstract
Abstract A solid pharmaceutical preparation for administration in dosage unit form comprising a therapeutically effective cardiac glycoside, whereby each dosage unit is to comprise a plurality of bodies, each of said bodies having a pharmaceutically inert core and a layer thereon containing the glycoside and a polymer insoluble in gastric juice and soluble in intestinal juice, a process for preparing such preparation and a method of treatment employing the same.
Inventors
- 👤 Curt Henry Appelgren
- 👤 Conny Börje Bogentoft
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 16:02
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7028; A61K31/7034; A61K31/704; A61K9/00; A61K9/14; A61K9/16; A61K9/167; A61K9/1676; A61M; A61M5/00; A61M5/178; A61M5/31; A61M5/32; A61M5/3205; A61M5/3278
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
100 words
A pharmaceutical preparation comprising a cardiac glycoside in combination with a polymer, characterized in that said pharmaceutical preparation is in the form of a plurality of small bodies, each body comprising a fraction of a therapeutically effective dosage of the cardiac glycoside, whereby each body has a core made up of pharmaceutically indifferent material, and on said core a layer made up of a composition comprising the cardiac glycoside and an anionic carboxylic polymer being difficultly soluble or insoluble below a given pH value in the interval of pH 4-7.5 but being soluble at a pH above said given value.
Claim 2
Dependent Claim
100 words
A pharmaceutical preparation comprising a cardiac glycoside in combination with a polymer, characterized in that said pharmaceutical preparation is in the form of a plurality of small bodies, each body comprising a fraction of a therapeutically effective dosage of the cardiac glycoside, whereby each body has a core made up of pharmaceutically indifferent material, and on said core a layer made up of a composition comprising the cardiac glycoside and an anionic carboxylic polymer being difficultly soluble or insoluble below a given pH value in the interval of pH 4-7.5 but being soluble at a pH above said given value.
Claim 3
Dependent Claim
25 words
A solid pharmaceutical preparation according to claim 1 characterized in that the layer is a layer applied by spraying a solution of the components thereof.
Claim 4
Dependent Claim
102 words
A process for preparing a pharmaceutical preparation comprising a cardiac glycoside in combination with a polymer, characterized in that said pharmaceutical preparation is given the form of a plurality of small bodies, each body comprising a fraction of a therapeutically effective dosage of the cardiac glycoside, by providing a large number of cores made up of pharmaceutically indifferent material, with a layer made up of a composition comprising the cardiac glycoside and an anionic carboxylic polymer being difficultly soluble or insoluble below a given pH value in the interval of pH 4-7.5 but being soluble at a pH above said given value.
Claim 5
Dependent Claim
102 words
A process for preparing a pharmaceutical preparation comprising a cardiac glycoside in combination with a polymer, characterized in that said pharmaceutical preparation is given the form of a plurality of small bodies, each body comprising a fraction of a therapeutically effective dosage of the cardiac glycoside, by providing a large number of cores made up of pharmaceutically indifferent material, with a layer made up of a composition comprising the cardiac glycoside and an anionic carboxylic polymer being difficultly soluble or insoluble below a given pH value in the interval of pH 4-7.5 but being soluble at a pH above said given value.
Claim 6
Dependent Claim
22 words
A process according to claim 3 characterized in that the outer layer is applied by adding a solution of the components thereof.
Claim 7
Dependent Claim
15 words
A process according to claim 4 characterized in that the solution is applied by spraying.
Claim 8
Dependent Claim
21 words
A process according to claim 4 or 5 characterized in that the outer layer is applied in a fluid bed apparatus.
References Cited (Backward Citations)
No citation records indexed.
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