Patent CA1232837A successfully refreshed from Google Patents.
CA1232837A
Expired / Lapsed
CA
⏱️ 0.0 years remaining
Ultrasound contrast agent containing microparticles and gas micro-bubbles
Assignee: Bayer Pharma AG
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Filing: 1984-04-11
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Granted: 1988-02-16
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Expires: 2004-04-11
Abstract
Abstract ABSTRACT An ultrasound contrast agent containing micro-particles and gaseous micro-bubbles is described which contains, in a liquid carrier, a mixture of microparticles of a semi-solid or liquid surface-active substance and microparticles of a solid non-surface-active substance. In the case of ultrasound images, after intra-venous administration it permits the contrasting of the left-hand side of the heart, the myocardium and other organs, such as the liver, the spleen, the kidneys and the right-hand side of the heart.
Inventors
- 👤 Jurgen Hilmann
- 👤 Lothar Lange
- 👤 Ingfried Zimmermann
Bibliographic Details
Application Number
—
Jurisdiction
CA
Data Source
google_patents
Last Synchronized
2026-10-23 15:20
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/22; A61K49/222; A61K49/223; A61B; A61B17/00; A61B17/22; A61B2017/22082; A61B2017/22089; A61B90/00; A61B90/39; A61B2090/3925
Claims Analysis
Total Claims: 39
Claim 1
Independent Claim
44 words
A contrast agent for use in the ultrasound diagno-sis of the human or animal body, which comprises in a liquid car-rier a mixture of microparticles of a semi-solid or liquid sur-face-active substance and microparticles of a solid non-surface-active substance and micro-bubbles of a gas.
Claim 2
Dependent Claim
44 words
A contrast agent for use in the ultrasound diagno-sis of the human or animal body, which comprises in a liquid car-rier a mixture of microparticles of a semi-solid or liquid sur-face-active substance and microparticles of a solid non-surface-active substance and micro-bubbles of a gas.
Claim 3
Dependent Claim
66 words
A contrast agent as claimed in claim 1, wherein the semi-solid or liquid surface-active substance is a lecithin, a polyoxyethylene fatty acid ester, a glycerine polyethylene glycol ricinoleate, a polyoxyethylene-polyoxypropylene polymer, a sac-charose ester, a xyloglyceride, an unsaturated (C4-C20)-fatty alcohol, an unsaturated (C4-C20)-fatty acid, a mono-, or di- or tri-glyceride or a fatty acid ester, or a mixture of any two or more of such substances.
Claim 4
Dependent Claim
38 words
A contrast agent as claimed in claim 1 wherein the semi-solid or liquid surface-active substance is butyl stearate, soya oil saccharose glyceride or polyethylene glycol sorbitan monostearate, or a mixture of any two or more of such substances.
Claim 5
Dependent Claim
41 words
A contrast agent as claimed in claim 1 wherein the solid non-surface-active substance is a cyclodextrine, a mono-saccharide, a disaccharide, a trisaccharide, a polyol or an inor-ganic or organic salt, or a mixture of any two or more of such substances.
Claim 6
Dependent Claim
28 words
A contrast agent as claimed in claim 1 wherein the solid non-surface-active substance is galactose, lactose or ?-cyclodextrine, or a mixture of two or more of such substances.
Claim 7
Dependent Claim
30 words
A contrast agent as claimed in claim 1 wherein the microparticles of the semi-solid or liquid surface-active sub-stance are present in a quantity of from 0.01 to 5% by weight.
Claim 8
Dependent Claim
28 words
A contrast agent as claimed in claim 6 wherein the microparticles of the semi-solid or liquid surface-active sub-stance are present in a quantity of from 0.04 to 0.5%.
Claim 9
Dependent Claim
28 words
A contrast agent as claimed in claim 1 wherein the microparticles of the solid non-surface-active substance are pre-sent in a quantity of from 5 to 50% by weight.
Claim 10
Dependent Claim
28 words
A contrast agent as claimed in claim 8 wherein the microparticles of the solid non-surface-active substance are pre-sent in a quantity of from 9 to 40% by weight.
Claim 11
Dependent Claim
36 words
A contrast agent as claimed in claim 1 wherein the liquid carrier is water, a physiological electrolyte solution, an aqueous solution of a monohydric or polyhydric alcohol, or an aqueous solution of a mono- or di-saccharide.
Claim 12
Dependent Claim
21 words
A contrast agent as claimed in claim 10 wherein the liquid carrier is glycerine, polyethylene glycol or propylene glycol methyl ester.
Claim 13
Dependent Claim
17 words
A contrast agent as claimed in claim 10 wherein the liquid carrier is physiological sodium chloride solution.
Claim 14
Dependent Claim
24 words
A contrast agent as claimed in claim 1, 2 or 3 which contains microparticles of a mixture of butyl stearate and galactose in water.
Claim 15
Dependent Claim
26 words
A contrast agent as claimed in claim 1, 2 or 3 which contains microparticles of a mixture of soya oil saccharose glyceride and galactose in water.
Claim 16
Dependent Claim
29 words
A contrast agent as claimed in claim 1, 2 or 3 which contains microparticles of a mixture of polyethylene glycol sorbitan monostearate and galactose in physiological sodium chlo-ride solution.
Claim 17
Dependent Claim
28 words
A contrast agent as claimed in claim 1, 2 or 3 which contains microparticles of a mixture of palm oil xylite and galactose in physiological sodium chloride solution.
Claim 18
Dependent Claim
24 words
A contrast agent as claimed in claim 1, 2 or 3 wherein the microparticles have a median particle size of from 1 to 3µm.
Claim 19
Dependent Claim
43 words
A liquid medium for use in making up the contrast agent claimed in claim 1 which comprises a suspension of a mix-ture of microparticles of a semi-solid or liquid surface-active agent and microparticles of a solid non-surface active substance in a liquid carrier.
Claim 20
Dependent Claim
26 words
A liquid medium as claimed in claim 18 which con-tains from 0.01 to 5% by weight of the microparticles of the semi-solid or liquid surface-active agent.
Claim 21
Dependent Claim
26 words
A liquid medium as claimed in claim 19 which con-tains from 0.04 to 0.5% by weight of the microparticles of the semi-solid or liquid surface-active agent.
Claim 22
Dependent Claim
24 words
A liquid medium as claimed in claim 18 which con-tains from 5 to 50% by weight of the microparticles of the solid non-surface-active substance.
Claim 23
Dependent Claim
24 words
A liquid medium as claimed in claim 21 which con-tains from 9 to 40% by weight of the microparticles of the solid non-surface-active substance.
Claim 24
Dependent Claim
25 words
A liquid medium as claimed in claim 18 wherein the semi-solid or liquid surface-active substance is a substance(s) as claimed in claim 2 or 3.
Claim 25
Dependent Claim
23 words
A liquid medium as claimed in claim 18 wherein the solid non-surface-active substance is a substance(s) as claimed in claim 4 or 5.
Claim 26
Dependent Claim
22 words
A liquid medium as claimed in claim 18 wherein the liquid carrier is a liquid as claimed in claim 10 or 11.
Claim 27
Dependent Claim
24 words
A liquid medium as claimed in claim 18, 19 or 20 wherein the microparticles have a median particle size of from 1 to 3µm.
Claim 28
Dependent Claim
50 words
A diagnostic kit for use in the ultrasound diagno-sis of the human or animal body, which comprises (A) a container which contains a liquid carrier, and (B) a second container which contains a mixture of microparticles of a semi-solid or liquid surface-active substance and microparticles of a solid non-sur-face-active substance.
Claim 29
Dependent Claim
50 words
A diagnostic kit for use in the ultrasound diagno-sis of the human or animal body, which comprises (A) a container which contains a liquid carrier, and (B) a second container which contains a mixture of microparticles of a semi-solid or liquid surface-active substance and microparticles of a solid non-sur-face-active substance.
Claim 30
Dependent Claim
24 words
A diagnostic kit as claimed in claim 27 wherein the containers (A) and (B) each have a volume of from 5 to 10 ml.
Claim 31
Dependent Claim
26 words
A diagnostic kit as claimed in claim 27 wherein the ratio by weight of the surface-active substance to the non-sur-face-active substance is from 0.01 to 5:100.
Claim 32
Dependent Claim
22 words
A diagnostic kit as claimed in claim 27 wherein the surface-active substance is a substance(s) as claimed in claim 2 or 3.
Claim 33
Dependent Claim
22 words
A diagnostic kit as claimed in claim 27 wherein the non-surface-active substance is a substance(s) as claimed in claim 4 or 5.
Claim 34
Dependent Claim
22 words
A diagnostic kit as claimed in claim 27 wherein the liquid carrier is a liquid as claimed in claim 10 or 11.
Claim 35
Dependent Claim
24 words
A diagnostic kit as claimed in claim 27, 28 or 29 wherein the microparticles have a median particle size of from 1 to 3µm.
Claim 36
Dependent Claim
27 words
A diagnostic kit as claimed in claim 27, 28 or 29 which also comprises an injection syringe for transferring the contents of container (A) to container (B).
Claim 37
Dependent Claim
25 words
A diagnostic kit as claimed in claim 27, 28 or 29 wherein each of the containers (A) and (B) is a phial or an ampoule.
Claim 38
Dependent Claim
28 words
An ampoule or phial for use in ultrasound diagnosis of the human or animal body, which contains a contrast agent as claimed in claim 1, 2 or 3.
Claim 39
Dependent Claim
47 words
A process for the preparation of a contrast agent as claimed in claim 1, 2 or 3 wherein microparticles of a semi-solid or liquid surface-active substance and microparticles of a solid non-surface-active substance are mixed with a liquid car-rier and agitated until a homogeneous suspension is formed.
References Cited (Backward Citations)
No citation records indexed.
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