Patent AU686103B2 successfully refreshed from Google Patents.
AU686103B2
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Microparticles, method of producing them and their use for diagnostic purposes
Assignee: Bayer Pharma AG
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Filing: 1993-06-05
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Granted: 1998-02-05
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Expires: 2013-06-05
Abstract
Abstract The invention concerns contrasting agents for use in ultrasonic diagnostic, the contrasting agents consisting of gas-containing microparticles with shells made of polycyanoacrylates or polyesters of $g(a)-, $g(b)-, or $g(g)-hydroxycarboxylic acids. The invention also concerns a method of producing such contrasting agents.
Inventors
- 👤 Thomas Dr. Fritzsch
- 👤 Esther Hamacher
- 👤 Dieter Heldmann
- 👤 Frank Luders
- 👤 Joachim Siegert
- 👤 Michael Stein
- 👤 Volkmar Uhlendorf
- 👤 Werner Weitschies
Bibliographic Details
Application Number
—
Jurisdiction
AU
Data Source
google_patents
Last Synchronized
2026-11-08 05:14
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/22; A61K49/222; A61K49/223
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
40 words
Ultrasonic contrast media containing gas-containing microparticles with a particle diameter 10 /zm whose shell consists of polyalkyl cyanacrylates or polyesters of a, P or y hydroxycarboxylic acids, characterized in that the specific density of the microparticles is 0.7 gcm 3
Claim 2
Dependent Claim
40 words
Ultrasonic contrast media containing gas-containing microparticles with a particle diameter 10 /zm whose shell consists of polyalkyl cyanacrylates or polyesters of a, P or y hydroxycarboxylic acids, characterized in that the specific density of the microparticles is 0.7 gcm 3
Claim 3
Dependent Claim
24 words
Microparticles according to claim 1, wherein average particle diameter of said microparticles is 0.1 tzm to 5 pJm, preferably 0.2 gm to 2.0 pm.
Claim 4
Dependent Claim
23 words
Microparticles according to claim 1, wherein the specific Jensity of the particles ranges from 0.05 g/cm 3 to less than 0.7 g/cm 3
Claim 5
Dependent Claim
171 words
Proce:ss for the production of microparticles with particle diameter 10 Am and specific density 0.7 g/cm 3 wherein monomeric cyanacrylate is dispersed in an acid, aqueous S solution saturated with a gas, which optionally contains at least one surface-active substance, the particles obtained after 5 minutes to 3 hours of dispersing are separated, optionally washed with water, then taken up in a pharmaceutically acceptable suspension medium and freeze-dried. Process for the production ofmicroparticles with particle diameter 10 m and specific density 0.7 g/cm 3 wherein a polyester of an a, P or y hydroxycarboxylic acid, optionally together with a water-dispersible emulsifier, is dissolved in a solvent harmless to health and this solution is added under dispersing to a gaseous liquid, which, provided that the emulsifier has not already been added together with the polyester, contains a water-dispersible emulsifier, the particles obtained after 30 minutes to 2 hours of dispersing are separated, optionally washed with water, then taken up in a pharmaceutically acceptable suspension medium and freeze-dried. o ~II I IICI -1-
Claim 6
Dependent Claim
171 words
Proce:ss for the production of microparticles with particle diameter 10 Am and specific density 0.7 g/cm 3 wherein monomeric cyanacrylate is dispersed in an acid, aqueous S solution saturated with a gas, which optionally contains at least one surface-active substance, the particles obtained after 5 minutes to 3 hours of dispersing are separated, optionally washed with water, then taken up in a pharmaceutically acceptable suspension medium and freeze-dried. Process for the production ofmicroparticles with particle diameter 10 m and specific density 0.7 g/cm 3 wherein a polyester of an a, P or y hydroxycarboxylic acid, optionally together with a water-dispersible emulsifier, is dissolved in a solvent harmless to health and this solution is added under dispersing to a gaseous liquid, which, provided that the emulsifier has not already been added together with the polyester, contains a water-dispersible emulsifier, the particles obtained after 30 minutes to 2 hours of dispersing are separated, optionally washed with water, then taken up in a pharmaceutically acceptable suspension medium and freeze-dried. o ~II I IICI -1-
Claim 7
Dependent Claim
11 words
Microparticles obtained accord. ng to the process mentioned in claim 4.
Claim 8
Dependent Claim
9 words
Microparticles obtained according to the process mentioned in claim
Claim 9
Dependent Claim
18 words
Ultrasonic contrast media according to claim 1, wherein polybutyl, polyisopropyl or polyethyl cyanacrylate is used as polyalkyl cyanacrylate.
Claim 10
Dependent Claim
38 words
Ultrasonic contrast media according to claim 1, wherein poly-L-lactide is used as polyester of a hydroxycarboxylic acid. Ultrasonic contrast media according to claim 1, wherein air, nitrogen, oxygen, noble gases, carbon dioxide or their mixtures are used gas.
Claim 11
Dependent Claim
46 words
Process for the production ofmicropartiles according to claim 4, wherein the pH of the aqueous solution is between 1.8 and a S. 12. Process for the production of microparticles according to claim 11, wherein S hydrochloric acid or phosphoric acid is used to adjust the pH.
Claim 12
Dependent Claim
35 words
Process for the production of microparticles according to claim 4, wherein polysorbates, octyl or nonyl phenols, macrogol-glycerol esters or cetomacrogols or substances from the group of Poloxamers or their mixtures are used as surface-active substances.
Claim 13
Dependent Claim
54 words
Process for the production of microparticles according to claim 5, wherein phosphatidylcholine or sucrose-palmitate-stearate 15 or their mixtures is (are) used as water- dispersible emulsifier(s). I Y LI~ P III Process for the production ofmicroparticles according to cimm 5, wherein a lower alcohol is used as a solvent harmless to health for the polyester.
Claim 14
Dependent Claim
18 words
Process for the production of microparticles as claimed in claim 15 wherein the lower alcohol is ethyl alcohol.
Claim 15
Dependent Claim
20 words
Process for the production of microparticles according to claim 5, wherein water or glycerol 87% is used as gaseous liquid.
Claim 16
Dependent Claim
52 words
Process for the production of microparticles according to claim 4 or 5, wherein as suspension medium, water is used for injection purposes optionally with an addition of common salt and/or glucose and/or mannitol and/or lactose, which optionally in addition contains a surface- active substance according to claim 13 and/or a multivalent alcohol.
Claim 17
Dependent Claim
23 words
Ultrasonic contrast media, wherein the microparticles according to either claim 6 or claim 7 are resuspended in a pharmaceutically acceptable suspension medium. i
Claim 18
Dependent Claim
47 words
Ultrasonic contrast media according to claim 19, wherein as a pharmaceutically acceptable suspension medium, water is used for injection purposes, which optionally contains an addition of cormnon salt, glucose, mannitol and/or lactose and optionally in addition contains a surface-active substance according to claim 13 and/or multivalent alcohol.
Claim 19
Dependent Claim
22 words
Ultrasoric contrast media produced according to the process described in claims 4 and 5, wherein a final freeze drying is dispensed with.
Claim 20
Dependent Claim
24 words
Ultrasonic contrast media according to claim 1, wherein they are excited by irradiation of ultrasound to independent signals. M I I I I 23
Claim 21
Dependent Claim
19 words
Ultrasonic contrast media according to claim 21, wherein the independent sound signals are evaluated in the color Doppler mode.
Claim 22
Dependent Claim
62 words
Ultrasonic contrast media, microparticles and processes for the production of microparticles, substantially as herein described with reference to the examples. *e i 24 Abstract The invention relates to contrast media for the ultrasonic diagnosis of gas-containing microparticles whose shell consists of polycyanacrylates or polyesters of a, p or y hydroxycarboxylic acids, as well as processes for their production. /^^FL V.D/ I c
Claim 23
Dependent Claim
62 words
Ultrasonic contrast media, microparticles and processes for the production of microparticles, substantially as herein described with reference to the examples. *e i 24 Abstract The invention relates to contrast media for the ultrasonic diagnosis of gas-containing microparticles whose shell consists of polycyanacrylates or polyesters of a, p or y hydroxycarboxylic acids, as well as processes for their production. /^^FL V.D/ I c
References Cited (Backward Citations)
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