Antithrombotic medical materials and process for their production

Abstract

Abstract Antithrombotic medical materials and process for their production. The antithrombotic materials comprise a high-molecular compound having groups capable of reacting with an epoxy group, such as a hydroxy, amino, carboxyl or mercapto group, to which heparin is bound through an epoxy compound. In the materials, the amino groups of heparin are bound to the epoxy groups of the epoxy compound and, in addition, the above-described functional groups of the high-molecular compound are bound to the epoxy groups of the epoxy compound. Since the antithrombotic materials retain an antiagglutinating activity of heparin, they possess bioadaptability and are significantly advantageous as medical materials. In addition, heparin cannot be easily released in vivo because of the presence of a firm bond between heparin and the high-molecular compound through the epoxy compound, thus being stable enough to be used for a long period of time.

Inventors

• 👤 Nobuyoshi Kashiwagi
• 👤 Masatomi Sasaki
• 👤 Hiroki Sakakibara
• 👤 Kazuhiko Hagiwara

Bibliographic Details