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USRE33403E Expired / Lapsed US ⏱️ 0.0 years remaining

Method for treating disorders of the vascular and pulmonary systems

Assignee: Stolle Milk Biologics Inc
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Filing: 1989-01-13
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Granted: 1990-10-23
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Expires: 2009-01-13
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Abstract

Abstract A method for treating vascular disorders or pulmonary disorders associated with smoking in an animal which comprises: adminstering to the animal milk collected from a bovid being maintained in a hyperimmune state, in an amount and for a time sufficient to produce anti arteriosclerotic or antiaging vascular effects or sparing effects on lung tissue.

Inventors

  • 👤 Ralph J. Stolle
  • 👤 Lee R. Beck

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 12:49
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/20; A61K35/48; A61K35/54; C; C07; C07K; C07K2317/00; C07K2317/10; C07K2317/11

Claims Analysis

Total Claims: 18
Claim 1
Independent Claim 125 words
A method of lowering lipid blood stream levels in an animal which comprises: administering to said animal milk collected from a bovid being maintained in a hyperimmune state against a mixture of antigens comprising Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus pyogenes, A. Type 1; Streptococcus pyogenes, A. Type 3; Streptococcus pyogenes, A. Type 5; Streptococcus pyogenes, A. Type 8; Streptococcus pyogenes, A. Type 12; Streptococcus pyogenes, A. Type 14; Streptococcus pyogenes, A. Type 18; Streptococcus pyogenes, A. Type 22; Aerobacter aerogenes; Escherichia coli; Salmonella enteritidis; Pseudomonas aeruginosa; Klebsiella pneumoniae; Salmonella typhimurium; Haemophilus influenzae; Streptococcus viridans; Proteus vulgaris; Shigella dysenteriae; Streptococcus, Group B; Diplococcus pneumoniae; Streptococcus mutans; and Corynebacterium Acne, Types 1 and 2, in an amount and for a time sufficient to produce said lowering effect.
Claim 2
Independent Claim 125 words
A method of lowering lipid blood stream levels in an animal which comprises: administering to said animal milk collected from a bovid being maintained in a hyperimmune state against a mixture of antigens comprising Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus pyogenes, A. Type 1; Streptococcus pyogenes, A. Type 3; Streptococcus pyogenes, A. Type 5; Streptococcus pyogenes, A. Type 8; Streptococcus pyogenes, A. Type 12; Streptococcus pyogenes, A. Type 14; Streptococcus pyogenes, A. Type 18; Streptococcus pyogenes, A. Type 22; Aerobacter aerogenes; Escherichia coli; Salmonella enteritidis; Pseudomonas aeruginosa; Klebsiella pneumoniae; Salmonella typhimurium; Haemophilus influenzae; Streptococcus viridans; Proteus vulgaris; Shigella dysenteriae; Streptococcus, Group B; Diplococcus pneumoniae; Streptococcus mutans; and Corynebacterium Acne, Types 1 and 2, in an amount and for a time sufficient to produce said lowering effect.
Claim 3
Dependent Claim 12 words
The method of claim 1 wherein said milk is in powdery form.
Claim 4
Dependent Claim 12 words
The method of claim 1 wherein said milk is in fluid form.
Claim 5
Dependent Claim 12 words
The method of claim 1 wherein said milk is in concentrated form.
Claim 6
Dependent Claim 14 words
The method of claim 1 wherein said milk is incorporated into a food product.
Claim 7
Dependent Claim 10 words
The method of claim 4 wherein said product is yogurt.
Claim 8
Dependent Claim 11 words
The method of claim 1 wherein said bovid is a cow.
Claim 9
Dependent Claim 105 words
The method of claim 1 wherein said bovid is maintained in said hyperimmune state by administering to said bovid booster injections of a mixture of antigens comprising Staphylococcus aureus; Staphylococcus epidermus; Streptococcus pyogenes, A. Type 1; Streptococcus pyogenes, A. Type 3; Streptococcus pyogenes, A. Type 5; Streptococcus pyogens, A. Type 8; Streptococcus pyogenes, A. Type 12; Streptococcus pyogenes, A. Type 14; Streptococcus pyogenes, A. Type 18; Streptococcus pyogenes, A. Type 22; Aerobacter aerogenes; Escherichia coli; Salmonella enteritidis; Pseudomonas aeruginosa; Klebsiella pneumoniae; Salmonella typhimurium; Haemophilus influenzae; Streptococcus viridans; Proteus vulgaris; Shigella dysenteriae; Streptococcus, Group B; Diplococcus pneumoniae; Streptococcus mutans; and Corynebacterium Acne, Types 1 and 2.
Claim 10
Dependent Claim 26 words
The method of claim 8 wherein said antigen or mixture of antigens booster is injected in a dose of 10 6 cells to 10 20 cells.
Claim 11
Dependent Claim 52 words
The method of claim 4 wherein said milk is prepared by a process which comprises: sensitizing a bovid with said mixture of antigens; administering boosters of said mixture of antigens of a dosage sufficient to induce and maintain a hyperimmume state in said bovid, and thereafter collecting said milk from said bovid.
Claim 12
Dependent Claim 21 words
The method of claim 10 wherein said process further comprises: pasteurizing said collected milk; and removing the fat from said milk.
Claim 13
Dependent Claim 11 words
The method of claim 1 wherein said milk is administered daily.
Claim 14
Dependent Claim 24 words
The method of claim 1, wherein said lipids are selected from the group consisting of triglycerides, cholesterol, low density lipids and mixtures thereof. .Iadd.
Claim 15
Independent Claim 59 words
A method of lowering lipid blood stream levels in an animal which comprises administering to said animal, in an amount and for a time sufficient to produce said lowering effect, milk collected from a bovid being maintained in a hyperimmune state against bacterial, viral or cellular antigens or a mixture of two or more of said antigens. .Iaddend. .Iadd.
Claim 16
Independent Claim 59 words
A method of lowering lipid blood stream levels in an animal which comprises administering to said animal, in an amount and for a time sufficient to produce said lowering effect, milk collected from a bovid being maintained in a hyperimmune state against bacterial, viral or cellular antigens or a mixture of two or more of said antigens. .Iaddend. .Iadd.
Claim 17
Dependent Claim 280 words
The method according to claim 14 wherein said bovid is maintained in a hyperimmune state against a bacterial antigen or antigens. .Iaddend. .Iadd.16. A method according to claim 15 wherein said bacterial antigens are selected from the group consisting of Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus pyogenes, A. Type 1; Streptococcusi pyogenes, A. Type 3; Streptococcus pyogenes, A. Type 5; Streptococcus pyogenes, A. Type 8; Streptococcus pyogenes, A. Type 12; Streptococcus pyogenes, A. Type 14; Streptococcus pyogenes, A. Type 18; Streptococcus pyogenes, A. Type 22; Aerobacter aerogenes; Salmonella enteritidis; Klebsiella pneumoniae; Salmonella typhimurium; Haemophilus influenzae; Streptococcus viridans; Proteus vulgaris; Shigella dysenteriae; Streptococcus, Group B; Diplococcus pneumoniae; Corynebacteriumn, Acne, Types 1 and 2; Pseudomonas aeruginosa; Pseudomonas maltophiia; Streptococcus equisimili; Streptococcus dysgalactiae; Streptococcus uberis; Streptococcus bovis; Pasteurella multocida; Pasteurella haemolytica; Pasteurella multocida; Moraxella bovis; Actinobacillus lignieresi; Corynebacterium renale; Fusobacterium necrophorum; Bacillus cereus; Salmonella dublin; Salmonella heidleberg; Salmonella paratyphi; Yersinia enterocolitica; Streptococcus mutans; and Escherichia coli. .Iaddend. .Iadd.17. The method of claim 15 wherein said bacterial antigens are selected from the group consisting of Pseudomonas aeruginosa; Pseudomonas maltophiia; Streptococcus equisimili; Streptococcus dysgalactiae; Streptococcus uberis; Streptococcus bovis; Streptococcus bovis; Pasteurella multocida; Pasteurella multocida; Pasteurella haemolytica; Pasteurella multocida; Moraxella bovis; Actinobacillus lignieresi; Corynebacterium renale; Fusobacterium necrophorum; Bacillus cereus; Salmonella dublin; Salmonella heidleberg; Salmonella paratyphi; and Yersinia enterocolitica. .Iaddend. .Iadd.18. The method of claim 15 wherein said bacterial antigen comprises Streptococcus mutans. .Iaddend. .Iadd.19. The method of claim 18 wherein said antigen is selected from the group consisting of Streptococcus mutans AHT, Streptococcus mutans BHT, Streptococcus mutans 10499, and Streptococcus mutans 6715. .Iaddend. .Iadd.20. The method of claim 18 wherein said antigen comprises Streptococcus mutans AHT, Streptococcus mutans BHT, Streptococcus mutans 10499, and Streptococcus mutans 6715. .Iaddend.
Claim 18
Dependent Claim 166 words
.Iadd.1. The method of claim 15 wherein said bacterial antigen comprises Escherichia coli. .Iaddend. .Iadd.22. The method of claim 14 or 15 wherein said milk is in a powdery form, a fluid form, a concentrated form, incorporated into a food product, or in yogurt. .Iaddend. .Iadd.23. The method of claim 14 or 15 wherein said bovid is maintained in said hyperimmune state by administering to said bovid booster injections of an antigen or antigens. .Iaddend. .Iadd.24. The method claim 14 or 15 wherein said milk is prepared by a process which comprises sensitizing a bovid with an antigen or antigens; administering boosters of said antigen or antigens of a dosage sufficient to induce and maintain a hyperimmune state in said bovid and thereafter collecting said milk from said bovid. .Iaddend. .Iadd.25. The method of claim 24 wherein said process further comprises: pasteurizing said collected milk; and removing the fat from said milk. .Iaddend. .Iadd.26. The method of claim 14 wherein said milk is administered daily. .Iaddend.

References Cited (Backward Citations)

US3128230A Cited
US3376198A Cited
US3911108A Cited
US4377569A Cited

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