Abstract A stable boronated ( 10 B-labeled) compound, sodium mercaptoundecahydrododecaborate is infused in the form of the disulfide dimer, [ 10 B]Na 4 B 24 H 22 S 2 , at a dose of about 200 μg 10 B per gm body weight. The infusion is performed into the blood or peritoneal cavity of the patient slowly over a period of many days, perhaps one week or more, at the rate of roughly 1 μg 10 B per gm body weight per hour. Use of this particular boronated dimer in the manner or similarly to the manner so described permits radiotherapeutically effective amounts of boron to accumulate in tumors to be treated by boron neutron capture radiation therapy and also permits sufficient retention of boron in tumor after the cessation of the slow infusion, so as to allow the blood concentration of 10 B to drop or to be reduced artificially to a radiotherapeutically effective level, less than one-half of the concentration of 10 B in the tumor.
A method of utilizing boron neutron capture therapy for treatment of brain tumors which comprises slowly infusing a radiotherapeutically effective amount of [ 10 B]Na 4 B 24 H 22 S 2 at an infusion rate of approximately 1 μg 10 B per gram of body weight per hour into the patient and thereafter exposing the diseased area to neutron irradiation.
Claim 2
Independent Claim
61 words
A method of utilizing boron neutron capture therapy for treatment of brain tumors which comprises slowly infusing a radiotherapeutically effective amount of [ 10 B]Na 4 B 24 H 22 S 2 at an infusion rate of approximately 1 μg 10 B per gram of body weight per hour into the patient and thereafter exposing the diseased area to neutron irradiation.
Claim 3
Dependent Claim
35 words
The method of claim 1 wherein the [ 10 B]Na 4 B 24 H 22 S 2 is slowly infused over a period of at least one week to yield high tumor/blood and tumor/cerebrum concentrations.
Claim 4
Dependent Claim
34 words
The method of claim 1 wherein [ 10 B]Na 4 B 24 H 22 S 2 is slowly infused using a dosage of about 200 μg of 10 B per gm of body weight.