US7374874B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bacteriophages that infect Bacillus bacteria (Anthrax)
Assignee: University of Northern Iowa Foundation
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Filing: 2003-04-22
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Granted: 2008-05-20
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Expires: 2023-04-22
Abstract
Abstract The invention provides bacteriophages that infect Bacillus bacteria, including Bacillus anthracis , and compositions containing the bacteriophages. The invention also provides methods for using the bacteriophages of the invention to prevent and treat infection of an organism by Bacillus bacteria. Methods and materials to decontaminate a surface or an organism that is contaminated with Bacillus bacteria or Bacillus spores is also provided.
Inventors
- 👤 Michael H. Walter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 05:12
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/02; C12Q1/04; A; A61; A61K; A61K35/00; A61K35/66; A61K35/76; C12N; C12N7/00; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/569; G01N33/56911; G01N33/56983; C12N2795/00; C12N2795/00011; C12N2795/10011; C12N2795/10111; C12N2795/10132; C12N2795/10211; C12N2795/10232
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
25 words
An isolated bacteriophage selected from the group consisting of NikoA (ATCC accession number PTA-4171), DDBa (ATCC accession number PTA-4172), and MHWa (ATCC accession number PTA-4173).
Claim 2
Dependent Claim
25 words
An isolated bacteriophage selected from the group consisting of NikoA (ATCC accession number PTA-4171), DDBa (ATCC accession number PTA-4172), and MHWa (ATCC accession number PTA-4173).
Claim 3
Dependent Claim
27 words
An antibacterial nutrient broth containing al least one bacteriophage selected from NikoA (ATCC accession number PTA-4171), DDBa (ATCC accession number PTA-4172), and MHWa (ATCC accession number PTA-4173).
Claim 4
Dependent Claim
27 words
An antibacterial nutrient broth containing al least one bacteriophage selected from NikoA (ATCC accession number PTA-4171), DDBa (ATCC accession number PTA-4172), and MHWa (ATCC accession number PTA-4173).
Claim 5
Dependent Claim
33 words
A pharmaceutical composition comprising a bacteriophage selected from the group consisting of NikoA (ATCC accession number PTA-4171), DDBa (ATCC accession number PTA-4172) and MHWa (ATCC accession number PTA-4173), and a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
33 words
A pharmaceutical composition comprising a bacteriophage selected from the group consisting of NikoA (ATCC accession number PTA-4171), DDBa (ATCC accession number PTA-4172) and MHWa (ATCC accession number PTA-4173), and a pharmaceutically acceptable carrier.
Claim 7
Dependent Claim
22 words
The composition of claim 3 , wherein the pharmaceutically acceptable carrier is an aerosol, a paste, a powder, or an injectable formulation.
Claim 8
Dependent Claim
23 words
A kit comprising a bacteriophage selected from NikoA (ATCC accession number PTA-4171), DDBa (ATCC accession number PTA-4172), and MHWa (ATCC accession number PTA-4173).
Claim 9
Dependent Claim
23 words
A kit comprising a bacteriophage selected from NikoA (ATCC accession number PTA-4171), DDBa (ATCC accession number PTA-4172), and MHWa (ATCC accession number PTA-4173).
Claim 10
Dependent Claim
15 words
A bacteriophage of claim 1 , wherein the bacteriophage is coupled to a detectable marker.
Claim 11
Dependent Claim
23 words
The bacteriophage of claim 6 , wherein the detectable marker is an enzyme, a fluorescent tag, a radioactive tag or a colorimetric tag.
Claim 12
Dependent Claim
12 words
The bacteriophage of claim 1 , wherein said bacteriophage infects Bacillus anthracis.
Claim 13
Dependent Claim
31 words
A recombinant bacteriophage comprising the genome of NikoA (ATCC accession number PTA-4171), DDBa (ATCC accession number PTA-4172), or MHWa (ATCC accession number PTA-4173), wherein said genome comprises an exogeneous nucleic acid.
Claim 14
Dependent Claim
31 words
A recombinant bacteriophage comprising the genome of NikoA (ATCC accession number PTA-4171), DDBa (ATCC accession number PTA-4172), or MHWa (ATCC accession number PTA-4173), wherein said genome comprises an exogeneous nucleic acid.
Claim 15
Dependent Claim
17 words
The recombinant bacteriophage of claim 9 , wherein the exogeneous nucleic acid encodes a drug resistance gene.
Claim 16
Dependent Claim
16 words
The recombinant bacteriophage of claim 1 , wherein the drug is tetracycline, ampicillin, streptomycin or rifampicin.
Claim 17
Dependent Claim
16 words
The recombinant bacteriophage of claim 9 , wherein the exogeneous nucleic acid is an expression cassette.
Claim 18
Dependent Claim
15 words
The recombinant bacteriophage of claim 12 , wherein the expression cassette comprises a regulatory sequence.
Claim 19
Dependent Claim
15 words
The recombinant bacteriophage of claim 13 , wherein the regulatory sequence is a Bacillus promoter.
Claim 20
Dependent Claim
16 words
A pharmaceutical composition comprising the recombinant bacteriophage of claim 9 , and a pharmaceutically acceptable carrier.
Claim 21
Dependent Claim
23 words
The pharmaceutical composition of claim 15 , wherein the pharmaceutically acceptable carrier is an aerosol, a paste, a powder, or an injectable formulation.
Claim 22
Dependent Claim
22 words
An antibacterial nutrient broth containing at least one bacteriophage, wherein at least one bacteriophage is the recombinant bacteriophage of claim 9 .
Claim 23
Dependent Claim
9 words
A kit comprising the bacteriophage of claim 9 .
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