US7285113B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
Assignee: NanoPass Tech Ltd
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Filing: 2003-07-18
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Granted: 2007-10-23
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Expires: 2023-07-18
Abstract
Abstract A device for the transport of fluids through a biological barrier includes a number of microneedles projecting from the front face of a substrate. A conduit is associated with each of the microneedles to provide a fluid flow path for transport of fluid through a hole in the biological barrier formed by the corresponding microneedle. Each of the microneedles is configured to provide a penetrating tip, and each conduit terminates at an opening which is proximal with respect to the microneedle tip. Also described are microneedle-based devices with integrated MEMS pumping configurations for withdrawal and/or delivery of fluids, and remote healthcare systems based on such devices.
Inventors
- 👤 Yehoshua Yeshurun
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 11:42
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14507; A61B5/1451; A61B5/14514; A61B5/15; A61B5/150007; A61B5/150015; A61B5/150022; A61B5/150053; A61B5/150061; A61B5/150099; A61B5/150206; A61B5/150213; A61B5/150221; A61B5/150274; A61B5/150282; A61B5/150847; A61B5/15087; A61B5/150977; A61B5/150984; A61M; A61M37/00; A61M37/0015; A61M2037/003; A61M2037/0053; Y; Y10; Y10T; Y10T29/00; Y10T29/49; Y10T29/49826
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
151 words
A device for the transport of fluids through a biological barrier, the device comprising: (a) a substrate having a front surface; (b) an array of microneedles projecting from said front surface, each of said microneedles having a maximum width dimension of no more than about 400 μm and a maximum height dimension of no more than about 2 mm, each of said microneedles including: (i) a penetrating tip, (ii) at least one inclined surface extending from said penetrating tip towards said front surface of the substrate, and (iii) an enclosed fluid flow channel formed through the microneedle and intersecting with said inclined surface, wherein, in a cross-section through said microneedle adjacent to said front surface of said substrate, said fluid flow channel defines a first area having a first centroid and an outline of said microneedle defines a second area having a second centroid, said first and second centroids being non-coincident.
Claim 2
Independent Claim
151 words
A device for the transport of fluids through a biological barrier, the device comprising: (a) a substrate having a front surface; (b) an array of microneedles projecting from said front surface, each of said microneedles having a maximum width dimension of no more than about 400 μm and a maximum height dimension of no more than about 2 mm, each of said microneedles including: (i) a penetrating tip, (ii) at least one inclined surface extending from said penetrating tip towards said front surface of the substrate, and (iii) an enclosed fluid flow channel formed through the microneedle and intersecting with said inclined surface, wherein, in a cross-section through said microneedle adjacent to said front surface of said substrate, said fluid flow channel defines a first area having a first centroid and an outline of said microneedle defines a second area having a second centroid, said first and second centroids being non-coincident.
Claim 3
Independent Claim
160 words
A device for the transport of fluids through a biological barrier, the device comprising: (a) a substrate having a front surface; (b) an array of microneedles projecting from said front surface, each of said microneedles having a maximum width dimension of no more than about 400 μm and a maximum height dimension of no more than about 2 mm, each of said microneedles including: (i) a penetrating tip, (ii) at least one inclined surface extending from said penetrating tip towards said front surface of the substrate, an entirety of said at least one inclined surface being inclined, and (iii) a fluid flow channel formed through the microneedle and intersecting with said inclined surface, such that, in a cross-section through said microneedle adjacent to said front surface of said substrate, said fluid flow channel is circumscribed by a closed wall, a first region of said closed wall having a thickness greater than that of a second region of said closed wall.
Claim 4
Independent Claim
160 words
A device for the transport of fluids through a biological barrier, the device comprising: (a) a substrate having a front surface; (b) an array of microneedles projecting from said front surface, each of said microneedles having a maximum width dimension of no more than about 400 μm and a maximum height dimension of no more than about 2 mm, each of said microneedles including: (i) a penetrating tip, (ii) at least one inclined surface extending from said penetrating tip towards said front surface of the substrate, an entirety of said at least one inclined surface being inclined, and (iii) a fluid flow channel formed through the microneedle and intersecting with said inclined surface, such that, in a cross-section through said microneedle adjacent to said front surface of said substrate, said fluid flow channel is circumscribed by a closed wall, a first region of said closed wall having a thickness greater than that of a second region of said closed wall.
Claim 5
Dependent Claim
24 words
The device of claim 2 , wherein said first region and said second region lie substantially on opposite sides of said fluid flow channel.
Claim 6
Dependent Claim
31 words
The device of claim 2 , wherein the thickness of said closed wall in said first region is at least twice the thickness of said closed wall in said second region.
Claim 7
Dependent Claim
35 words
The device of claim 2 , wherein the thickness of said closed wall in said first region is at least equal to a maximum dimension of said fluid flow channel as viewed in said cross-section.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2010-10-22 | 2011-04-23 | 2011-10-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2014-10-22 | 2015-04-23 | 2015-10-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2018-10-22 | 2019-04-23 | 2019-10-23 | $7700.00 | Window Closed / Lapsed |